Transcript Tissue/Organ Engineering

Tissue/Organ Engineering
What will be covered.
• Types of cells
• Scaffolds
• Biocompatibility
How can this be useful?
• Heart Disease
• 6,000,000
• 550,000
• Pulmonary Disease (COPD)
122,572
• 12,000,000
• Renal Failure
• 530,000
• Heart – 0.6
• Lung – 2.5
• Kidney – 3.3
8,030
What is tissue engineering?
What kinds of cells are used?
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Specialized cells
How do we obtain them?
Stem Cells: Embryonic Vs. Placental/Umbilical
Use the patient’s cells
What methods are used to create scaffolds?
• Things to consider
• Biocompatibility
• Vascularization
• Biodegradability
• Decellularization
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ECM
Allows for vascularization
Allows for optimal biocompatibility
A “natural” scaffold
Summary
• This is still a developing technology.
• The best method of scaffolding is using the process of decellularization,
but there are others.
• Stem cells can also be used to allow cells to grow and specialize.
Works Cited
• Meul. CoeurHumain. Digital image. Commons Wikimedia. N.p., 22 Jan. 2008. Web.
<https://commons.wikimedia.org/wiki/File:CoeurHumain.svg>.
• "Organ Matching Process." Organdonor.gov. N.p., n.d. Web. 26 Sept. 2015.
• "Tissue Engineering." Wikipedia. Wikimedia Foundation, n.d. Web. 26 Sept. 2015.
• "Decellularization." Wikipedia. Wikimedia Foundation, n.d. Web. 26 Sept. 2015.
• Baptista, Pedro M. “The Use of Whole Organ Decellularization for the Generation of a Vascularized Liver
Organoid.” Hepatology 53.2 (2011): 604-617. Print
• "About Us." <http://ottlab.mgh.harvard.edu/?page_id=2>.
• “The ABCs of Organ Engineering” http://www.wakehealth.edu/Research/WFIRM/Our-Story/Inside-theLab/Inside-the-Lab.htm
• “Tissue Engneering: How to build a heart” http://www.nature.com/news/tissue-engineering-how-to-build-aheart-1.13327
• “Vacanti mouse” <https://en.wikipedia.org/wiki/Vacanti_mouse>