Transcript Hemophilia - Mrs. GM Biology 200

Hemophilia
TAYLOR ARLEDGE, NNEOMA OBIESHI,
ANGELINA BAJRA
What is Hemophilia?
 Hemophilia is an X linked recessive blood disease
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Most common in Caucasian men, as most x liked genetic disorders
Results from a deficiency in the clotting factor
Often called Christmas Disease or the Disease of the Royals
 Hemophilia A and Hemophilia B
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Hemophilia A would be the most common out of the two
 due to the decreased activity of factor VIII which aids in clotting
Hemophilia B is much like Hemophilia A except the deficiency
involves Factor IX
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Known as Christmas Disease
How is Hemophilia inherited?
 How the disorder is inherited?
 Through a carrier Mother or a Hemophiliac Father (paired
with normal mates or combined
 Can someone be a carrier for Hemophilia
 Women are always the carriers of this disease
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Women have two x chromosomes and can only he hemophiliacs if
they hare homozygous for the recessive trait
 Inheritance patterns
Symptoms & Diagnosis
Symptoms include
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Excessive bleeding
Bleeding in the joints
Joint scarring
Bruises
Hemorrhage
 Demographics
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“Hemophilia A affects between
one in 5,000 to one in 10,000
males in most
populations.”(Gale)
How the disease is
diagnosed
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Genetic testing
Amniocentesis DNA
testing of fetal cells shed
into the amniotic fluid for
genetic mutations.
 chorionic villus sampling
examines proteins for the
defects that lead to
hemophilia. (gale)
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Treatment and Cures
 Treatment
 Usually the patient is injected with the deficient factor
Hemophiliacs A receiving Factor VIII
 Hemophiliacs B receiving Factory IX
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Other simpler modes of handling this disorder are wearing
protective clothing on bodily areas that go through much
contact as in the hands feet or arms.
 Effectiveness of Treatmnent
 the treatment is used in emergency settings only and not daily
administered.
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Works when needed.
Works Cited
Wilson, Jennifer F. "Hemophilia." Gale Virtual Reference Library. Ed. Brigham
Narins. Vol.1 and 2 ed. N.p., 2006. Web. 7 Feb. 2011.
<http://go.galegroup.com/ps/
i.do?&id=GALE%7CCX3451500193&v=2.1&u=s0351&it=r&p=GVRL&sw=w
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"What Is Hemophilia, Hemophilia A, and Hemophilia B?" National Heart, Lung and Blood
Institute. July 2009. Web. 07 Feb. 2011.
<http://www.nhlbi.nih.gov/health/dci/Diseases/hemophilia/hemophilia_what.html>.
Raabe, Michelle, Ph.D. Hemophilia. New York City: Chelsea House, 2008. Print
Pacheco, Maria. "Hemophilia." Magill's Medical Guide. Ed. Dann P. Dawson. Vol. 3.
Pasadena, California: Salem Press Inc., 2008. 1282-1285. Print.
“Hemophilia." Human Diseases and Conditions. Ed. Niel Tzenburg, M.D. New york,
New York: Charles Scribner's and Sons, 2000. 434-438. Print.