Transcript Genetics

Genetics
Genetics and Behaviour
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For behaviour to be affected by natural
selection, some variation in behaviour must be
inherited
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If not, the characteristics could not be passed on
right?
Otherwise, could contribute to fitness, but could NOT
evolve
Remember, only heritable, genetically
transmitted variation can be affected by
selection
Introduction
‘Trying to determine how much of a
behaviour is due to genetics and how
much is due to the environment is like
trying to determine how much the area of
a field is caused by its length and how
much by its width’
Donald Hebb
 Nature v. Nurture is a stupid argument
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Key Terms
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Gene
Genotype
Phenotype
Chromosome
Locus
Allele
Diploid
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Haploid
Gamete
Zygote
Recessive
Dominant
Homozygous
Heterozygous
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Note that it is not the
case that the
chromosomes just
pair off, there is also
recombination
So, each sex cell is a
little bit different
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This Recombination is the source of much
genetic variation, and it occurs in all but
the simplest organisms
Mutation is the ONLY source of new
genetic material
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Most mutations are bad, usually lethal
Some are neutral
Some (very few) confer an advantage
How DNA works
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Base pairs
Adenine
Thymine
Cytosine
Guanine
C -> G
A -> T
QuickTime™ and a
TIFF (U ncompressed) decompressor
are needed to see this picture.
DNA and genes
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Genes encode proteins
DNA -> RNA
RNA -> Proteins
Proteins -> phenotype
Environment -> genes
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Though some genes are
less responsive than others
QuickTime™ and a
TIFF (U ncompressed) decompressor
are needed to see this picture.
An Example
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Human Ocular cutaneous albinism
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I wonder where that example came from…..
Single gene for the production of melanin
A – normal
a - bad
Dominance / Recessive relationship
AA, aA, Aa all lead to normal, aa leads to me
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Leslie and Rick
Aa and Aa
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Or some variation
aA and Aa
Aa and aA
aA and aA
Phenotypically normal
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1 in 4 chance of
having a kid with aa
They did, on June 23,
1965
My genotype MUST
be aa because there
is no dominance
They got the looks, but I got the brains……..
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Danny and Stephanie
may be carriers, or
they may not be, they
are phenotypically
normal
Their kids could carry
the allele, assuming
they do
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My kids MUST carry
the allele, as they had
an a from me, and, an
A from Isabelle
We know they got an
A from Isabelle by
looking at their
phenotype
Behavioural Effects
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I don’t spend much time in the sun
I have very poor vision (20/200, melanin
guides the growth of the visual system)
No binocular vision
Can’t drive a car
Not very good at baseball
Huge IQ…….
Partial Dominance
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Telleogryllus oceanicus
and T. commodus
Males call to attract
mates (function)
Song is species specific
Male hybrids produce
hybrid song
Female hybrids prefer
hybrid song.
Another cool example
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Mutant hamsters
Martin Ralph
Tau gene
TT normal 24 hr
cycle
tt 20 hr cycle
Tt or tT gives 22 hr
cycle
Teenage Mutant Ninja Hamsters
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Single Gene effect
Affects brain development
SCN specifically
May be cognitive effects
Learning Mutants in Drosophila
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The white rat of
genetics
Dunce
Amnesia
Stuck
Coitus interruptus
Bang sensitive
Per
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This one is cool…
So why are there different
alleles?
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On the surface, if some allele is better
than some other, why does it not replace
all other alleles?
Neutral alleles?
Environmental fluctuation
Heterozygote superiority
Frequency dependent selection
And, of course, mutation
So, What Does it All Mean?
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What does ‘a gene for behaviour’ mean?
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Behavioural difference caused by genetic difference
Does not mean that a complex behavioural sequence
is caused by a single gene
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Many other genes contribute to behaviour
Some difference must be caused by genetic differences
Just because something has a genetic basis
does not make in unchangeable!!!!
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Remember, Genotype is NOT Phenotype