Transcript PowerPoint-Präsentation

MOLECULES
OF LIFE &
MUTATIONS
CHARLES UNIVERSITY
versity is proud to announce the visitation
ED SCHWARZ, Professor of Pathophym the Biocenter of the Medical University
Austria who will introduce here a novel
c as well as lecture format.
Medicine as well as Biology, from semester 3
kindly invited to attend this 4 days interactive
ciplinary course, and will thereby receive 4
ME
0:00 – 12:00
ure I: Crucial importance of understanding proteins for
iseases in general
4:00 – 16:00
ture II: Understanding oncogenesis by understanding
s
0:00 – 12:00
e PC room for learning a molecular modelling software
the PDB and OMIM data banks
f disease cases to work out underlying molecular
homework)
ision on the date of case presentation
4 or 7 or 9 or 10 or 11 or 14, 10:00 – 12:00
students homework and discussion
s
ns fees. Limited number of students allowed.
This lecture intends to give introductory information on the
importance of understanding the normal as well as abnormal
stucture (as resulting from gene mutations or from allosteric
effectors) of proteins for health as well as for understanding
diseases.
Next day follows a hands-on course in a PC room where
attendees will receive a detailed step-by-step description for
performinig practical molecular modelling on the PC by using
appropriate software. Using the X,Y, Z coordinates of atoms, as
deposited in the Brookhaven Protein Data Bank, PDB, students
can „create“ the 3D structure of crystallographically elaborated
proteins, alone or in interaction with small or large ligands
such as substrates, drugs or DNA or other proteins. Attendees
will learn also how to use the OMIM (Online Inheritance in Men)
Data Bank from where they can retrieve the published
mutations and consequent diseases. Arginine Vasopressine
precursor and Diabetes insipidus serve as an illustative and
informative example.
A practical PC course on
molecular modelling and
explaining genetic diseases
November 24 – 25, 2015
by
Prof. Siegfried Schwarz,
Medical University Innsbruck, Austria
and
Ass.Prof. Jiri Hatina, Charles University in Prague,
Medical Faculty in Pilsen, Czech Republic
Dr. Karel Drbal, Charles University in Prague, Faculty of
Science, Czech Republic
After this course, students will get assigned an individual
protein and disease that they will have to elaborate as
homework just in the way they have learnt it in the course.
They should prepare a short lecture in Power Point.
On the last day, students will present their homework in front
of all attending colleagues including the Professors. So,
everybody learns from the others, kind of a multiplication
effect.
One of the powers of molecular modelling resides in its informative value in
displaying molecules, in total or in portions thereof, in different formats such
as wireframe, protein backbone, atoms, overall surface etc. It is possible to
turn the molecule in all directions and to see in real time the various aspects
of it. Thereby, various structural characteristics can be recognized, domains
of certain structure or charge or hydrophobicity or shape or other properties,
which can serve e.g. as ligand-binding domain, as DNA-binding domain or
as drug-metabolizing pocket or as a domain for any other biological
purpose. Most importantly, points of mutation, as documented in the OMIM
and other data bases, can be „mapped“ into such a model in order to
understand which function of the protein would thus be altered and whether
this change in structure would be would be loss or gain or recessive or
dominant.
Sponsored by