Transcript Targil4
Developmental biology Signaling Targil handout See chapter 6 of edition 6 OR 7 of Gilbert -or- distributed in later editions Targil – Signal transduction We have seen many developmentally regulative processes (we’ll see many more) **cells need information from their environment How is that information received and transduced? Received Transduced Communication between cells – comprehensively: 3 kinds of signal sources OTHER SUB-CLASS names for soluble ligand signals: (Further acting – through the bloodstream – endocrine) (Abutting cells – juxtacrine) (Cell release then re-uptake – autocrine) Protein kinases I: S/T kinases Prot. kinases I: S/T kinase ligands HOMOLOGS Phylogenetic tree Branches arise from: gene duplications -paralogs speciation -orthologs Protein kinases II: T(Y)K/RTK signaling II. RTK signaling II. RTK signaling II. RTK signaling MAPKKK MAPKK MAPK II. RTK signaling II. RTK signaling II. RTK signaling IIa. YK signal: Jak mediated signaling IIa. YK signal: Jak mediated signaling Hedgehog signaling pathway Wnt (wg) signaling pathway Notch signaling pathway Notch signaling pathway Stochastic Process of Selection Conserved apoptosis pathway NFkappaB pathway -here, interfacing proteolysis pathway Similar to (but not homologous to): Human blood clotting cascade – Also a series of (extracellular) proteolytic cleavages NFkappaB pathway -innate immunity in both. ALSO D/V in Dros. Steroid hormone pathway -no need for cell surface receptor Models of the Hippo pathway in Drosophila and mammals. Zhao B et al. Genes Dev. 2010;24:862-874 Copyright © 2010 by Cold Spring Harbor Laboratory Press