Transcript DNA is a Nucleic Acid

DNA Replication
–
http://www.youtube.com/watch?v=hfZ8o9D1tus (YouTube)
Transcription & Translation
–
–
–
http://molo.concord.org/database/activities/273.html (FLASH)
What makes a firefly glow?
PBS: The Secret of Life (YouTube)
Translation
–
http://www.abdn.ac.uk/~clt011/flash/samples/protein.swf (FLASH)
DNA is a Nucleic Acid
http://ghr.nlm.nih.gov/dynamicImages/understandGenetics/basics/chromosome_structure.jpg
http://www.phoenix5.org/glossary/graphics/CellChromoDNAGene.gif
All nucleotides consist of 3 parts:
--- 5 C sugar, N base & Phosphate group
http://fig.cox.miami.edu/~cmallery/150/chemistry/sf3x6.jpg
Only complementary bases will
pair together (i.e., form a bond)
http://fig.cox.miami.edu/~cmallery/150/gene/c16x6base-pairs.jpg
http://fig.cox.miami.edu/~cmallery/150/gene/16x5bc.jpg
DNA forms a Double Helix
http://test3-sftt.terc.edu/units/genes/common_content/images/s01_helix-ladder_01.gif
http://www.starsandseas.com/SAS_Images/SAS_Genetics_images/DNA_images/dnamodel_1.jpg
Why does DNA need to be in the form
of chromatin for replication to occur?
http://www.eduvinet.de/mallig/bio/Repetito/Mitose1.html
 This cell is in interphase. Notice
the chromatin in the nucleus.
 This cell is in prophase. The
DNA has already replicated and
now the chromatin is getting
shorter (forming chromosomes).
DNA replication is semi-conservative
http://www.nicerweb.com/doc/class/bio100/Locked/media/ch14/DB14050.jpg
http://www.steve.gb.com/images/science/dna_replication_fork.png
DNA Replication
http://fig.cox.miami.edu/~cmallery/150/gene/c16x7copy-dna.jpg
DNA vs. RNA
http://images.clinicaltools.com/images/gene/dna_versus_rna_reversed.jpg
TRANSCRIPTION (DNA  RNA)
http://www.brooklyn.cuny.edu/bc/ahp/BioInfo/graphics/Transcription.01.GIF
http://fig.cox.miami.edu/~cmallery/150/gene/dogma.htm
CODONS code for Amino Acids
http://evolution.berkeley.edu/evosite/evo101/images/codon_GCA.gif
http://coris.noaa.gov/glossary/codon_186.jpg
The Genetic Code
http://fig.cox.miami.edu/~cmallery/150/gene/sf11x10.jpg
DNA  mRNA  Protein
http://www.iir.suite.dk/IIR/15genes/images/15DNAToProt2.gif
TRANSLATION = the synthesis
of proteins (polypeptides)
http://mandevillehigh.stpsb.org/2005site/teacher_sites/laura_decker/dna_and_rna_diagrams_files/image008.jpg
http://ghs.gresham.k12.or.us/science/ps/sci/ibbio/chem/nucleic/chpt15/tRNA.gif
tRNAs carry amino acids to the proper
location on the mRNA strand
Anticodons are complementary to the
codons of mRNA
The Central Dogma of
Molecular Genetics
http://www.anselm.edu/homepage/jpitocch/genbio/transcrtransl.JPG
http://www.anselm.edu/homepage/jpitocch/genbio/codonsAA.JPG
http://library.thinkquest.org/C004535/protein_synthesis.html
Double-stranded DNA will unzip
for TWO reasons…
http://www.sidwell.edu/us/science/vlb98/projects/protein/smarks/dnarepvsprosynp.gif
GENE MUTATIONS – insertions,
deletions & substitutions
http://fajerpc.magnet.fsu.edu/Education/2010/Lectures/26_DNA_Transcription.htm
SICKLE-CELL ANEMIA
http://www.anselm.edu/homepage/jpitocch/genbio/effectsofsickle.JPG
http://healthgate.partners.org/images/si55551158.jpg
Sickle-Cell Anemia is the result
of a substitution (point) mutation
http://fajerpc.magnet.fsu.edu/Education/2010/Lectures/26_DNA_Transcription.htm
Aa x Aa
http://www.sciencemuseum.org.uk/exhibitions/genes/225.asp
SICKLE-CELL ANEMIA
TAY-SACHS DISEASE
http://lovequilts2005children.homestead.com/RachaeliF.html
http://www.snof.org/maladies/tay.html
Rachaeli F.
Born: October 25, 2002
Illness: Tay-Sachs Disease (terminal)
PHENYLKETONURIA (PKU)
http://www.newbornscreening.info/tools/GraphicsLib/phenylketonuria.jpg
CYSTIC FIBROSIS (CF)
http://images.webmd.com/images/hw/media66/medical/hw/nr551844.jpg
http://www.cfgenetherapy.org.uk/images/phyisiotherapy.jpg
HUNTINGTON’S DISEASE (HD)
http://www.curehd.org/
PLEASE HELP ME SAVE MY KIDS!!!
My name is Robert Bishop. I am 43 years
old and the father of five at-risk children
(ages 18, 15, 12, 9, and 7). In 1998, I sold
my computer software business to take
up the cause of fund raising and public
awareness for a terminal illness called
Huntington's Disease (HD). Unless a cure
is found, 2 or 3 of my children will
tragically die from this disease. Each has
a 50% chance of having inherited a
defective gene from their first mother,
Amy (who became symptomatic for HD in
her mid-twenties).
AMNIOCENTESIS
http://amniocentesis.upmc.com/Images/Sub/ImageAmnio.jpg
GENETIC ENGINEERING
http://floti.bell.ac.uk/mcgarvieg/Insulin.gif
CLONING
http://static.howstuffworks.com/gif/cloning-sheep.gif
http://www.vamr.org/img/scnt_flow.jpg