Ch. 12.1: DNA stores Information
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Transcript Ch. 12.1: DNA stores Information
Ch. 12.1: DNA stores Information
Objectives:
1. Describe how DNA is
packed within the
nucleus.
2. Explain the
significance of the
Human Genome
Project.
Vocab:
Genome
Histone
DNA Structure Review
Genome: Complete set
of genetic material
in an organism
(order of bases).
Can fit into nucleus
b/c of packing
system.
Coiled around proteins (spools): HISTONES
Coiled are coiled into helical fiber to make
CHROMOSOME
Human Genome Project
Goal: Determine …
1. Sequence of bases in the
human genome.
2. Sequences code for proteins
(exons).
3. Function of resulting
proteins.
Began in 1990
1st Draft completed in 2000
Government funded agency cooperated w/ private companies
Results published on web and available to scientists.
12.2: Chromosomal Disorders
Objectives:
1. Relate Down syndrome
and non-separation of
chromosomes.
2. Describe how
chromosomes can be
damaged.
3. Explain how a “jumping
gene” can affect other
genes.
Vocab.:
Trisomy
Down syndrome
Non-disjunction
Duplication
Insertion
Deletion
Inversion
Translocation
Transposon
Non-disjunction
Homologous chromosomes or sister
chromatids fail to separate during
meiosis.
Result: Gametes with abnormal # of
chromosomes… Offspring with abnormal #
of offspring
Non-disjunction
Most embryos with abnormal chromosome # result in miscarriage.
Cause: Random
Increased risk with age (35 +)
Trisomy
Having 3 of a particular chromosome.
Examples
- Chromosome # = 47
Trisomy 21: Down
syndrome
1 in 700 births
Most common
Cognitive and physical
impairments
Trisomy 18: Edwards
syndrome
(more lethal)
Trisomies &
Maternal Age
Pre-egg cells in
girls have gone
through Meiosis I.
Meiosis II happens
b4 ovulation.
Longer time lag =
increase chance of
nondisjunction
Trisomies of Sex Chromosomes
XXX Female
XXY: Klinefelter Male
XYY: Male
Turner’s Syndrome
XO Female
45 Chromosomes
Chromosomal Duplications
Part of a chromosome is repeated.
Vary from fatal to developmental abnormalities.
Chromosomal Deletions
Part of a chromosome is deleted.
Very serious damage
Ex: Williams Syndrome
http://abcnews.go.com/2020/video/williams-syndrome-children-friend-health-disease-hospital-doctors-13817012
Partial deletion of chromosome 7
Chromosome Inversion
Fragment breaks and reverses on the same
chromosome.
Not as lethal.
Chromosome Translocation
Fragment of one chromosome attaches to ANOTHER,
DIFFERENT chromosome.
If there is an UNEQUAL swap of segments, results can
serious.
•
•
List of Chromosome Disorders
http://www.netnet.net/mums/mum_chro.htm
Transposons: Jumping Genes
Discovered by Barbara McClintock
Experimented w/ corn; Jumping genes interfered w/ corn
pigments.
•
•
List of Chromosome Disorders
http://www.netnet.net/mums/mum_chro.htm
Transposons
Single genes that can
move around.
“Jump” from one
chromosome to
another.
If they insert in the
middle of an existing
gene, that gene will be
disrupted.