Transcript Bio290-01-Introduction+Mendelian Genetcs

Welcome to Bio 290,
Introduction to Genetics!
Today’s Agenda:
1. Introduction of Colleagues
2. Introduction to Course, Expectations, and
Website
3. Reviewing the Foundations of Genetics (InClass Assignment 1)
4. Introduction to Single-Gene Inheritance (Ch 2)
5. Poster Project Brainstorm
“Big Ideas” in
Single-Gene
Inheritance:
1. Gene and
Chromosome
Structure and
Packing
“Big Ideas” in Single-Gene Inheritance:
2. Representations of Genes and Chromosomes
“Big Ideas” in Single-Gene Inheritance:
2. Representations of Genes and Chromosomes
“Big Ideas” in Single-Gene Inheritance:
2. Representations of Genes and Chromosomes
“Big Ideas” in Single-Gene Inheritance:
3. Mendel’s
Contributions
Watch for some new
terms here! What does
it mean to be
haplosufficient, or
haploinsufficient?
What’s a leaky
mutation?
“Big Ideas” in Single-Gene Inheritance:
4. Chromosome Structure and Function During Meiosis
FIGURE: Model of the synaptonemal complex (SC). Lateral elements (light blue
rods) of homologous chromosomes align and synapse together via a meshwork of
transverse filaments (white lines) and longitudinal filaments (dark blue rods). The
longitudinal filaments are collectively referred to as the "central element" of the
SC. Ellipsoidal structures called recombination nodules (e.g., gray ellipsoid) are
constructed on the central region of the SC. (Image: Mississippi Genome Exploration Lab)
“Big Ideas” in Single-Gene Inheritance:
5. Value and Diversity of Model Organisms
What advantage
might a haploiddominant organism
like yeast, above,
provide for a
geneticist?
What advantages
do Drosophila,
above, provide for
a geneticist?
What advantages
do mice as a model
organism offer a
geneticist? Any
disadvantages?
“Big Ideas” in Single-Gene Inheritance:
6. Sex-Liked Genes Have Unusual Inheritance Patterns
What’s unusual about
white-eyed fruit flies?
Watch for new terms:
What does it mean to
be hemizygous?
What’s a?
pseudoautosomal
region
“Big Ideas” in Single-Gene Inheritance:
7. Pedigree Analysis is a Powerful Way to Represent Inheritance
Poster Project Brainstorm:
What are the most interesting
recent developments in
Genetics? What do I find
fascinating about the field?
Reminders for Next Week
1. Review Paper - Start Reading! (Pre-class
assignment on Review Paper due Thursday at 2)
2. Read Chapter 2: Focus on key points we’ve
identified today to help you prepare for the Quiz
3. Quiz 2- Posted by Monday at noon, due by
Wednesday at noon.
4. Don’t forget to use our fabulous Discussion
Room!