Transcript Summary
Canadian Bioinformatics Workshops www.bioinformatics.ca Module 5: Future 1 Module 5: Future 2 Summary • Module 1: Introduction to Gene Lists • Module 2: Gene Set Analysis • Module 3: Inferring Regulatory Mechanisms Governing Sets of Genes • Module 4: Pathway and Network Analysis Module 5: Future 3 Round Table Discussion • What does the future hold for Omics data analysis? • What questions would you like to explore? • What functions would you like to see in software? • Discussion Module 5: Future 4 Gene list analysis future • Incorporating high-throughput functional data – New tools are being developed to compare gene lists against automatically updated databases of functional data to answer the questions like: “in which datasets are my genes best clustered” or “can I find more genes like these”? – In development: • GeneMANIA: http://www.genemania.org – Published: • SPELL: http://imperio.princeton.edu:3000/yeast (yeast) Module 5: Future 5 Gene Regulation Future • TF catalogs with functional annotations • Allows users to explore candidate TFs to find relevance to their biological situation • Coming • Gene regulation annotations • Greater community annotation efforts • TF binding profiles • Emerging PBM data and ChIP-Seq data will greatly expand • CRM discovery • Motif discovery for TF combinations • Over-representation for ChIP “peaks” Module 5: Future 6 Networks and Pathways • Community curation • Increasing network detail – more biologically relevant networks • Network biomarkers • Chemical genomics • Requires: sophisticated software for curation and data integration Module 5: Future 7 Visualizing Sub-gene Entities Module 5: Future 8 Participant Ideas • What do you want to be able to do? • Given a gene list, what characteristics would you want to explore? Module 5: Future 9