Transcript Bioinformatics and Medical Informatics

The Convergence of Bioinformatics
and Medical Informatics
-- PL Chang, M.D.
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Total Genes – 28939
(07-28-2006) – Build 36.1
Chromosome
Genes
Chromosome
Genes
Chromosome
Genes
1
2776
9
1207
17
1442
2
1866
10
1094
18
438
3
1473
11
1841
19
1624
4
1164
12
1355
20
717
5
1281
13
556
21
367
6
1528
14
1220
22
756
7
1474
15
961
X
1344
8
1025
16
1108
Y
322
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Protein Synthesis
38320 Structures
(Aug 22, 2006)
Protein 3D structure
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Informatics United: Combining Medical
Informatics and Bioinformatics
• The use of image processing techniques for the analysis of
the dynamics of cell nuclei
• The application of medical informatics tools for data
mining in bioinformatics
• Clinical decision support systems based on bioinformatics
have the potential to improve medical diagnostics and lead
to a personalized delivery of healthcare
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Clinical Applications
• Diagnostic tools
– Gene chips, protein chips
– Early detection of infectious agent, congenital
disorders, susceptibility to disease and,
eventually, idiosyncrasy
• Drug Discovery/Development
– Gene expression profile
– Protein structure and candidate molecules
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Clinical Bioinformatics
Medical informatics
Bio-decision support system
Systems biology
Genomics
Proteomics
Comparative
genome analysis
Microarray
Pharmacogenomics
Structure databases
Bioinformatics
in cancer research
Personalized medicine
Clinical Applications
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CGMH EHR
EHR
Clinical Bioinformatics
電
子
病
歷
Diseases
Genes
Proteins
SNPs
Pathways
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How Will the Medicine of the
21st Century Be Like?



BioMedical informatics
 Medical informatics and bioinformatics
Intelligent representation, storage, retrieval
and application
 Data and Text mining
Personalized medicine
 Diagnosis, treatment, and prognosis
based on bioinformatics
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