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Epigenetic dysregulation in hepatocellular carcinoma: focus on
polycomb group proteins
Sandy Leung-Kuen Au;Irene Oi-Lin Ng ;Chun-Ming Wong ;
State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong,
Hong Kong, China ;
Fig.1 Post-translational modification of histone amino N-terminal tails. The nucleosome contains an octamer of histone molecules 2 copies of histone H2A, H2B, H3 and H4
wrapped around by 147 bp of DNA strand. Histone N-terminal tails protruding from nucleosome core are subject to variety of post-translational modifications at the specific
amino acid residues. Me: methylation; P: phosphorylation; Ac: acetylation; Ub: ubiquitylation.
Frontiers of Medicine,2013,7(2),231-241. Doi:10.1007/s11684-013-0253-7