Transcript Document
Blank to maintain numbering 1 Midterm • There will be one • Periodic Table, Hemoglobin, DNA, Anfinsen, Tamiflu will feature • • Study TOPIC guide will appear Syllabus says Oct. 18; I’m thinking 25 may be more likely. Will inform next week or by e-mail 2 Anfinsen A1) each molecule more or less instantly goes to fully correct form. It’s a ‘snowball rolling down hill’ model, where each correct association greatly enhances the subsequent. So my 2nd bond is quicker than your 1st. Predicts precise tracking of disulfides formed vs. achieved activity 3 Anfinsen A1 A1) each molecule more or less instantly goes to fully correct form. It’s a ‘snowball rolling down hill’ model, where each correct association greatly enhances the subsequent. So my 2nd bond is quicker than your 1st. Predicts precise tracking of disulfides formed vs. achieved activity 4 Anfinsen A2 5 A2) Only correct bonds form, but with different rates for different bonds--so there is an order and timing of bond formation that is the same for all molecules. So A-A’ might form quickly; B-B’ slowly, etc. Deadline = line + dead think about it deadline |ˈdedˌlīn| noun 1 this definition not relevant 2 historical a line drawn around a prison beyond which prisoners were liable to be shot. Does it really make sense to designate that period at the end as the target as opposed to that at the beginning? Is it really the case that your schedule is such that all available times just happen to fall at the last minute? 6 7 Beating Tamiflu Themes: Evolution: then and now amino acids, mutations, folding: they matter How evolution happens • Good ideas are rewarded not sought/planned • There’s no mechanism for foresight, so it cannot be that way 8 How the flu happens 9 http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif Just passin’ through 10 http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif Just passin’ through 11 http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif Just passin’ through 12 http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif Tamiflu: you shall not pass! 13 a.k.a. oseltamivir http://en.wikipedia.org/wiki/File:Oseltamivir-3D-balls.png And it goes like this... 14 Note: this is modeled, not a crystal structure http://www.ks.uiuc.edu/Research/influenza/