Transcript For Skin

TO FEEL & STAY MORE YOUTHFUL
Our Skin
Understanding Our
Skin Structure - Hypodermis
• The skin is made up of 3 layers.
• The bottom or deepest layer
of the skin is the hypodermis.
It is made up of fatty tissue
that cushions & supports the
two layers of skin above it.
Understanding Our
Skin Structure - Dermis
• The middle layer of skin
• It contains collagen & elastin which give the
skin its form, shape & elasticity.
Understanding Our
Skin Structure - Dermis
• The collagen & elastin in young, healthy skin are
constantly renewed.
• Older skin tends to sag & wrinkle because the
collagen & elastin are damaged & not renewed as
often.
• The dermis is also where the blood capillaries, hair
follicles, sweat & oil glands are found.
• As we age, oil glands become less active, causing
skin to become drier & more prone to the formation
of fine lines.
Understanding Our
Skin Structure - Epidermis
• The top layer of the skin
• This is where the
critical function
of cell renewal
takes place.
Skin Renew Process
• New skin cells are born at the base & slowly move upward,
losing moisture & flattening out as they rise until they
form a paper thin barrier at the top of the epidermis.
• The cells in younger skin are replaced about every
15-30 days. But as we age, this process takes twice as long.
Skin Renew Process
RESULTING IN
Major Factors affecting
our skin to age
(1) Sun
- 80% of visible skin ageing is due to UV light exposure.
- the UV light damages moisture barrier in the epidermis & elastin and
collagen in the dermis.
- resulting in skin loses its elasticity, forming of fine lines and wrinkles
formation of dark spots on the skin as skin produces excess melanin.
Damage to the
moisture barrier
Skin produces
excess melanin
Elastin &
Collagen
damaged
Major Factors affecting
our skin to age
(2) Hormonal Ageing
- The first five years following menopause, the skin loses up to 30% of its
supportive collagen fibres.
- As a result, the skin becomes thinner, skin becomes less capable of
storing moisture, becomes drier and wrinkles deepen.
- Now, the skin is more prone to damages caused by free radicals as the
cell renewal process slows down.
(3) Pollution
- Airborne pollutants such as dirt and
dust, present in most modern environments,
especially in densely populated or
industrialized areas – are harmful to the skin.
Major Factors affecting
our skin to age
(4) Air-Conditioning
- Dry, dehydrate the skin, leaving epidermis dry.
- Dehydration damages the skin’s barrier function and increases evaporation of dermal
moisture.
(5) Sleep
- Sleep deprivation leads to dull complexion & dark, puffy under-eye circles.
- Skin tend to premature lines and wrinkles.
Major Factors affecting
our skin to age
(6) Stress
- Anxiety and anger will increase sebum production in the skin.
(7) Alcohol
- Drinking in excess leads to skin dehydration and robs the body’s nutrients
(Vitamin A,B,C and the minerals magnesium & zinc.)
(8) Smoking
- Smoking reduces the supply of blood to the skin’s surface, restricting the flow of
essential nutrients.
- Skin dull and greyish in colour
- Smokers tend to have thinner skin & premature appearance of
lines and wrinkles.
The Ageing Process
(A)
Wrinkle
- UVR causes wrinkle and melanin to form.
- UVA penetrate into the dermis to damage the collagen.
- UV induce production of free radical (O2) species (ROS) & matrix metalloproteinases
(MMP)
- (O2) present in our cell can form harmful radical (ROS).
MMP
ROS
ROS
UVA penetrate
into dermis –
damage collagen
MMP
ROS
MMP
The Ageing Process
Antioxidant attenuates the ROS & MMP & allow skin to
regenerate properly
Antioxidants
Antioxidants
MMP
AntiMMP
oxidants
AntiROS
oxidants
ROS
MMP
SUPERFOODS !
FOR BEAUTY ON THE INSIDE OUT
Perfect Combination Of
3-in-1 formula
(Radiant Skin + Breast Firming + Antioxidant)
PRESENTING…
BEUCOGEN COLLAGEN
(Product Benefits)
1.
Repair body cell
2.
Improve skin fairness
3.
Restore skin cell elasticity
4.
Reduce fine lines & pigmentation
5.
Retain skin moisture content
6.
Smoothen skin
7.
Eliminate free radicals
8.
Prevent cell oxidation
9.
Firm up breasts
10.
Antioxidant
Active Ingredients
(For Skin)
Hydrolysed Marine Collagen
(3,000mg)
•
Collagen is main protein surrounding every cell. 6% of body weight.
•
Collagen is one the long, fibrous structural protein.
•
Main component of cartilage, ligaments, tendons, bone & skin.
•
Made up of three polypeptide strands, twisted together & stabilized by hydrogen bonds
•
More than 28 types of collagen. Over 90% of collagen are of type 1,2,3,&4
•
Collagen 1- skin, tendon, vascular, ligature, organ , bone
•
Collagen 2- cartilage
•
Collagen 3- reticular fiber found in artery walls, skin, intestines & uterus
•
Collagen 4 – form bases of cell basement membrane
•
After age 25, collagen synthesis reduce at a rate of 1.5% and reduce into half after age of 60, skin become thinner
& less firm
•
Characteristics of marine collagen in Ladies Collagen:* Marine Low Molecular Collagen
* Average Molecular Weight 3,000Da – the lighter the molecular weight (< 5,000Da) increases absorption.
* High solubility
* High digestion by human enzyme
* Low moisture absorption
* Less fish smell & taste white fine powder.
* Easy handling
L-Arginine (200mg)
•
Key building block to repair damaged tissue & bone
•
Improve blood circulation
•
Help in wound healing
•
Positive immune modulating – anticancer effects
•
Generate muscle mass
•
Reduce body fat
L-Lysine (200mg)
•
Amino acid for growth & tissue repair
(one of the nine essential amino acid which the body can’t produce
ourselves, have to take from food)
•
Produce antibodies, hormones, enzymes, collagen formation
•
Assist calcium absorption
•
Lowering cholesterol
Active Ingredients
(Firming)
Soy Extract (Isoflavonoid)
(200mg)
•
Isoflavones = phytoestrogen(plant hormone)
which resembles human estrogen in
chemical structure.
•
Functions to firm skin & breast and
balancing the hormone.
•
Contain 40% isoflavonoid which helps in :
- Prevention of breast cancer
- Prevent osteoporosis- bone
- Ease menopause symptoms – hot flushes
- Reduce heart disease risk
Soy Protein
• High source of protein which
subsequently increases our
protein in the body
• Functions to provide protein
to rebuild cell
(2,000mg)
Oligo (oligosaccharides )
(2,400mg)
• Decrease gastrointestinal
transit time
• Helps to encourage the
growth of friendly bacteria
• Improves constipation &
diarrhea
Active Ingredients
(Antioxidant)
Vitamin C
(50mg)
• An antioxidant as it protects the body against oxidative stress
• Vitamin C in combination with collagen, allows the collagen
molecule to assume its triple helix structure and making
vitamin C essential to the development and maintenance of
scar tissue, blood vessels, and cartilage.
Sources of
Vitamin C :
Citrus Fruits eg. Oranges, grapefruit
Rose hips are particularly high in
vitamin C
Manufacturing Flow
Chart
(Marine Collagen)
Marine Hydrolyzed collagen
Spray Drying
Sterilization
Concentration
Filtration
Enzymatic Hydrolysis
Purification
Extraction (by hot water)
Acid treatment
Degreasing
100% fish skin (bone, skin, cartilage, scale)
ENZYMATIC HYDROLYSIS:
1) SHORT CHAIN PEPTIDES
2) LOW MOLECULAR WEIGHT,3000D
3) NO FISHY ODOUR
4) NEUTRAL TASTE
5) GOOD SOLUBILITY IN WATER
6) CLEAR SOLUTION
7) HIGH AMINO ACID PROFILE
Double Blind Placebo
(Clinical Evaluation)
Examining for :
1)
Moisture content of skin surface
2)
Skin elasticity
3)
Flexibility of skin
4)
Microscopic 3D skin surface analysis
5)
Statistical analysis – the difference before and after (Non-parametric Mann-Whitney test with placebo)
(P-value of less than 0.05 was taken as significant difference)
Double Blind Clinical Evaluation
•
21 women
• Age 13.3 – 34.1 years old
• Dry & rough skin
• Drinks 5g of Collagen per day
for 4 weeks
Test Result : Moisture content
45
This shows the
increase of moisture
content of skin surface
by approx.
moisture content%
40
35
30
60%
25
20
15
10
5
0
MM
before
placebo
after 2 weeks
after 4 weeks
Test Result : Flexibility of Skin
0.35
0.3
This shows that the
flexibility of skin had
increased by approx.
flexibility %
0.25
48%
0.2
0.15
0.1
0.05
0
MM
placebo
before
after 2 weeks
after 4 weeks
Test Result : Microscopic Skin
Surface Analysis
Before treatment
After 4 weeks treatment
BEFORE
AFTER
Conclusion – Test Analysis
•
•
•
•
Increase of moisture content
Increase of skin flexibility
Improvement of skin conditions
Certificate of safety - no side effect was
observed
CERTIFICATION
2) HALAL CERTIFIED
3) HACCP CERTIFICATION
4) GOOD MANUFACTURING PRACTICE
5) ISO CERTIFIED
CONTACT DETAILS
ZENOTEC PHARMA (M) SDN. BHD.
No.34-2, Jalan Anggerik Vanilla R31/R,
40460 Shah Alam,
Selangor Darul Ehsan
&
+603- 5122 3050
[email protected]