Transcript Ross et al., 2003

Genomica nutrizionale e approccio sperimentale
Go et al., 2003
La metilazione dei dinucleotidi 5’CpG3’ nei promotori
modula l’espressione dei geni
Mantenimento del pattern di metilazione durante la
duplicazione del DNA
L’acetilazione degli istoni
Nutrienti, attività genica e tumore
Ross et al., 2003
Componenti nutrizionali bio-attivi
Cancer prevention – the potential for diet to modulate molecular
signalling
Trends in Molecular Medicine, Manson, 2002
Manson, 2002
Depending on the circumstances, dietary compounds such as curcumin,
epigallocatechin gallate (EGCG), resveratrol and indole-3-carbinol (I3C) can upor down-regulate signalling to induce stress-response genes, or growth arrest
and apoptosis
Manson, 2002
Different chemopreventive agents can suppress the activity of
IKK, PI3K and/or PKB, inhibit the translocation of NF-kB to the
nucleus, or upregulate PTEN
Manson, 2002
Chemopreventive agents, such as indole-3-carbinol and epigallocatechin
gallate, can downregulate the expression or activity of CDKs and
cyclins, and upregulate CDK inhibitors such as p21 and p27, thereby
causing cell-cycle arrest in G1 .
Manson, 2002
Induction of stress-response genes by chemopreventive
chemicals
Manson, 2002
Restrizione calorica
Regime dietetico a basso contenuto calorico
in assenza di sottonutrizione o
malnutrizione
Allungamento della sopravvivenza del 50%
in lievito, nematodi, roditori e scimmie
Mattson, 2003
Mattson, 2003
Mattson, 2003
Koubova et al., 2003
Koubova et al., 2003
Pathways metabolici modificati dalla restrizione calorica
Koubova et al., 2003
Restrizione calorica e stress ossidativo
Hyon Jeen Kim et al., 2002
Possibile meccanismo attraverso cui la CR migliora
la funzionalità neuronale
Restrizione calorica e invecchiamento
Barja, 2002
CR manipulates the membrane fatty acid
components as an adaptive measure against agerelated peroxidizability — an efficient and smart
strategy to resist oxidative stress.
Barja, 2002
Shelke et al., 2003
Exercised CR animals are shown to have an additional extended
mean life span of ~10% beyond their nonexercised CR
counterparts.
Suppression of microsomal production of reactive oxygen species by CR. AS, ad libitumfed, sedentary; AE, ad libitum-fed, exercising; RS, CR, sedentary; RE, CR, exercising;
DCF = 2'7'-dichlorodihydrofluorescin
Yu et al., 2003
ARC (apoptosis repressor) levels in the brain of adult (12AD), old
(26AD), and old caloric restricted (26CR) Fischer 344 male rats
determined by Western blot analysis
Reduction of the incidence of tumors following
reduction of food intake
An even more remarkable example of CR’s ability to resist
irradiation is shown in the work of Gross and Dreyfuss, who
challenged mice with gamma irradiation to induce
tumorigenesis. They not only show a clear-cut tumor
suppression by CR (TABLE) but also that CR rats had a far
better capability of resisting one of the most deleterious forms
of stressors.
Shelke et al., 2003
Shelke et al., 2003
Lee et al., 1999