Transcript Metabolism of the whole organism

Metabolism of the whole organism
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Metabolic profiles of organs
Metabolic conditions
Blood glucose levels: 90 mg/dL
Fuel reserves
glucose
triacylglycerols
proteins
Metabolic homeostasis
Metabolic profiles
Brain
• Nervous system: maintain membrane
potentials
• uses glucose (120g/day)
• 60% of all glucose
• blood levels of 84.7 = 1mM in brain
• starvation use ketone bodies
• Heart : uses fatty acids or ketone bodies
Muscle
• contraction
• store glycogen
• resting use fatty acid
oxidation
• active use glucose
• starvation muscle
broken down to
alanine for
gluconeogenesis
Adipose Tissue
• uses fatty acids for
energy
• exports fatty acids
• glycerol exported out
to the liver
Liver & Kidney
• Liver: provides fuel to
other organs
• gluconeogenesis,
maintain blood glucose
• store glycogen
• export ketone bodies
• uses keto acids for fuel
• Kidney: needs energy for
active transport
• uses FA, KB, glucose,
amino acids,
• gluneogenic tissue
Metabolic conditions
• Controlled by
hormones
• insulin
• glucagon
• epinephrine
• Normal regulation of
blood glucose
Insulin secretion
Hormonal control
Hormones
Exercise
• fuels during different levels of exercise
• ATP production
Starvation/Fasting
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Fuel mobilization
after 3 day changes
long term shifts
hormonal changes
Starvation profiles
Fuel Modifications
Liver modifications
Diabetes
• types of diabetes
• changes in fuels
• problems
Insulin deficiency