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3DM: Protein Super-family Platforms 3DM Protein super-family data integration Tom van den Bergh Bio-Prodict 3DM: Protein Super-family Platforms Superimposing family structures These structures are sequentially all different: <80% 69 P450 structures 3DM: Protein Super-family Platforms Structure based alignments Structural conserved residues get the same 3Dnumber because these residues have a similar role in the proteins 3DM: Protein Super-family Platforms 3D number: the alignment structure link 3DM: Protein Super-family Platforms 3DM: Protein Super-family Platforms Amino acid data • Mutation data literature, Swiss-Prot, OMIM, … > 25.000 mutations searchable for effects!!!! • Structure data PPI, ligand contacts, bridges, solvent accessibility, flexibility/RMSD, … • Alignment data Conservation, correlated mutations, family specific residues, … • SNP data SNP databases, genome sequencing projects • Data integration All data are stored connected to the 3D numbering scheme and thus to the alignment, to the structures and each other 3DM: Protein Super-family Platforms 3DM: Protein Super-family Platforms 3DM: Protein Super-family Platforms 3DM: Protein Super-family Platforms 3DM: Protein Super-family Platforms 3DM: Protein Super-family Platforms 3DM: Protein Super-family Platforms