Transcript 三、确诊依据
宣武医院 儿科 I. Definition General connective tissue disease Autoimmune disease (B type ,A group Strep.) forerunner infection 1 to 4 weeks ago,Scarlet Fever,Tonsillitis ASO↑ Penicillin，RF↓，only 3~5% morbility trend of recurrent attack main clinical manifestions Fever Migratory Polyarthritis Carditis Chorea Annular erythem and subcutalleous nodules II. pathogenesis i. Molecular simulation for Streptococcus antigen B type, A group heamolytic strept. and the metabolite Antibody of strept. Cell wall Anti-M antibody cross reaction to human Vessel base membrane antibody of strept. membrane antibody of other cross reaction to human connective tissue and glycoprotein of heart valve cross reaction to human skeletal， muscle of heart and smooth muscle arteriole antibody of streptococcal extrotoxins and enzymes ASO， antihyaluronidase, antisreptokinase, antideoxyribose , etc. no cross reaction to human tissues ii. Immunocomplex antigen,antibody,complement iii. Damage of Cyto-immunity 1) lymphocyte increased respond for Streptococcus antigen 2) increased of leukocyte magration inhibition test decreased of blast transformation and hyperlasia (multiplication) reaction increased of nature killer cyto-toxic 3) the monocyte immuno-reactive abnormaly to Streptococcus antigen in patient tonsil iv. heredity the alloantigen in lymphocyte in the patient with rhumatic fever 99% postive in the normal people 14% postive III. Pathogen Exudation phase： 1~2months arthrosis、synovial menbrane、pericardium、pleura、progresion of exudation and degeneration Proliferative phase： 3~4 months progression of grenuloma：myocardium interstitial tissue、subendocardium、skin. base of rheumatism activity mark of rheumatism activity Sclerosis phase： 5~6months endocardium 、bicuspid valve 、tricuspid valve 、scarification IV. Clinical manifestions general signs Fever, Pale, Listless, poor appetite, Lose weight , Sweat (hyperidrosis), fatigue, tiredness, nose blood (epistaxs) abdomen pain Active carditis heart rate/temperature increased heart rate, gallop rhythm heart sounds weaken cardiac enlargement 5%~10% congestive heart failure heart beat spread all over the precordial aortic insufficiency. systolic murmur mitral stenosis murmurs：SM：mitral incompetence→half year DM：relative stenosis of mitral →more than 2 years prolonged PR interval pericaditis： polyarthritis migratory fashion heat,redness,swelling,severe pain knees hips wrists ellbows shoulders sydenham chorea combined with heart lession 40% emotional instrability and involuntary movements ataxia and slurring of speech——disphasia agraphia fine movement incoordination skin lession Erythema Marginatum subcutaneous nodule etythma annulare others pheumonia、pleuritis etc joints,scalp,spinalcolumn V. lab exammination i. blood routine ii. ESR↑:important mark iii. ASO：2w↑，2m↓ 20%no step up iv. detemination of special protein 1). CRP 2). mucoprotein 3). completment α γ globulin， IgG、 IgM↑ VI. Diagnosis Jones criteria (modified) for diagnosis of rheumatic fever Major manifestations carditis polyarthritis sydenham chorea erythema marginatum subcutaneous nodules Minor manifestations clinical: previous rheumatic fever or rheumatic heart disease polyarthralgia fever Laboratory: accute phase reaction, elevated erythrocyte sedimentation rate,C-reaction protein,leukocytosis prolonged PR interval PLUS Supporting evidence of preceeding streptococcal infection. that is : increased titers of antistreptolysin O or other streptococcal antibodys, positive throat culture for group A streptococcus. VII. Differential diagnosis i. post-streptococcal infection ii. viral myocarditis iii. juvenile rheumatoud：chronicity、symmetry、 progressive、inflamatery、destructive diseases VIII. Treatment i. general treatment bed rest ii. Diet iii. control of focus of infection iv. anti-rheumatisn 8~12weeks cortica hormone salilytic acid 3~6weeks v. treatment of heart failure vi. chorea IX. prognosis & prophylaxis early diagnosis thoroughly treatment reasonable prophylaxis 病毒性心肌炎诊断标准 一、临床诊断依据 （一）心功能不全、心源性休克或心脑综合征。 （二）心脏扩大（X线、超声心动图检查具有表现之 一）。 （三）心电图改变：以R波为主的2个或2个以上主要导 联（I、II、aVF、V5）的ST-T改变，持续4天以上伴 动态变化，窦房传导阻滞、房室传导阻滞、完全性右或 左束枝阻滞，成联律、多形、多源、成对或并行性早搏， 非房室结及房室折返引起的异位心动过速，低电压（新 生儿除外）及异常Q波。 （四）CK-MB升高或心肌肌钙蛋白（cTnL或cTnT）阳 性。 二、病原学诊断依据 （一）确诊指标：自患儿心内膜、心肌、心包（活检、病 理）或心包穿刺液检查，发现以下之一者可确诊心肌炎由 病毒引起。 1、分离到病毒。 2、用病毒核酸探针查到病毒核酸。 3、特异性病毒抗体阳性。 （二）参考依据：有以下之一者结合临床表现可考虑心肌 炎病毒引起。 1、自患儿粪便、咽拭子或血液中分离到病毒，且恢复期血 清同型抗体滴度较第一份血清升高或降低4倍以上。 2、病程早期患儿血中特异性IgM抗体阳性。 3、用病毒核酸探针自患儿血中可查到病毒核酸。 三、确诊依据 （一）具备临床诊断依据2项，可临床诊断为心肌炎。发病 同时或发病前1~3周有病毒感染的证据支持诊断者。 （二）同时具备病原学确诊依据之一，可确诊为病毒性心 肌炎，具备病原学参考依据之一，可临床诊断为病毒性心 肌炎。 （三）凡不具备确诊依据，应给予必要的治疗或随诊，根 据病情变化、确诊或除外心肌炎。 （四）应除外风湿性心肌炎、中毒性心肌炎、先天性心脏 病、结缔组织病以及代谢性疾病的心肌损害、甲状腺功能 亢进症、原发性心肌病、原发性心内膜弹力纤维增生症、 先天性房室传导阻滞、心脏自主神经功能异常、β受体功能 亢进及药物引起的心电图改变。 四、分期 （一）急性期：新发病，症状及检查阳性发现明显且多变， 一般病程在半年以内， （二）迁延期：临床症状反复出现，客观检查指标迁延不 愈，病程多在半年以上。 （三）慢性期：进行性心脏增大，反复心力衰竭或心律失 常，病情时轻时重，病程在1年以上。