Transcript S.V. Beleckaya

Disorder of metabolism of
vitamin B and
microelements
S.V. Beleckaya
Kharkiv Specialized Medical Genetic
Centre
 Vitamins (from lat. vita -«life») — low
molecular organic compounds of various
chemical nature, necessary for normal and life
and which have a high biological activity.
The most vitamins aren't synthesized in
human body. That's why they should be
regularly consumed in sufficient amount
with food or in the form of drugs. Exclusions
are vitamin K, sufficient amount of which is
synthesized in the large intestine by
bacteria, and vitamin B3, which is
synthesized by intestinal bacteria from
amino acid tryptophan.
B vitamins take part in the processes of
methylation, disorder of which more
frequently is diagnosed in children
with autism and autistic spectrum of
behavioral disorder.
Methylation is a simple process in which
the methyl group — one atom of carbon
and three atoms of hydrogen. Abnormal
methylation leads to disorders throughout
life, from impregnation to death. This
simple biochemical reaction has a great
significance for DNA synthesis, «switching
on» and «switching off» genes in a cell,
detoxification and metabolism.
Methylation helps the body to remove
toxins of heavy metals, including
mercurous, lead, stibous, arsenic. If
methylation in a child is abnormal, these
toxic metals accumulate, that negatively
influence on many functions of the body.
If chemical analysis of hair for mineral
content reveals a high level of toxic heavy
metals in the body, it shows methylation
disorder.
Methylation process
The most simple method to check
whether methylation is normal, is to
measure the level of homocysteine, folic
acid, vitamin B12 in blood. Increase of
homocysteine level is a result of decrease
of its methylation.
Decreased level of vitamin В12 – 18%;
Increased level of vitamin B12 (intake of
megadoses or cerebral deficiency) – 21%;
Revealed in gas chromatography
metabolites which point at vitamin B
deficiency – 47%.
Choosing treatment dose of vitamins is
based on 3 items:
1.Patient's age (a dose corresponds to age
norms);
2.Initial levels of vitamins in blood;
3.Level normalization or its absence in the
process of dynamic observation.
In DAN! therapy no one from
mentioned criteria is considered!
Dangers of overdosage of vitamins B
(hypervitaminosis):
Initial metabolism disorder impairs by a new
intoxification;
Parenchymatous organs are affected (first
of all the liver);
Allergic reactions;
Excess of vitamin B12 leads to hyperactivity,
in future there is possible hematopoiesis
inhibition;
Hypervitaminosis of vitamin B6 causes
polyneuropathy, motility in patients;
Excess of folic acid is often trigger of
oncopathology development.
Treatment with megadoses (often with
positive effect) and ignorance of abrupt
increase of vitamin level in blood can be
compared with one of type of drug abuse,
when energotonics are used — a person
receives the positive effect in the form of
good mood, clear thinking, long working
capacity... The outcome in a year is known
for everybody...
Vitamin B6 improves magnesium absorption from the
gastrointestinal tract and its cell penetration. If
magnesium level (in blood and urine) is within
norm, there is no necessity in its additional intake!
Exclusions are disorders of dopamine metabolism,
when positive effect is observed from treatment
with vitamin B6 together with magnesium (under
the control of homovanillic acid in urine).
In DAN! therapy it is accepted to prescribe vitamin
B6 only with magnesium, not knowing initial values
of metabolism...
Gas chromatography (24% of cases)
showed decreased level of vitamin B5
(pantothenic acid). We have seen that in
some children with autistic spectrum of
behavioral disorder, such deficiency was
combined with specific body and mouth
odor. Correction of vitamin B5 level led to
odor disappearance.
In some cases, the most prominent
positive effect was observed in
nutrition correction by dietary
enrichment with products with a high
content of necessary vitamin
Deficiency of macroand microelements
The following deficiencies are revealed by
gas chromatography more frequently in
children with autism and autistic spectrum
of behavior disorder: magnesium
deficiency (23%), zinc deficiency (9%),
selenium deficiency (9%) and
molybdenum deficiency (7%).
Magnesium deficiency
- Disorders of carbohydrate metabolism;
- Disorders of neurotransmitter metabolism;
- Long deficiency leads to accumulation of
Ni, Pb, Cd, Be, Al in the body.
Hypotonia, weakness, sleepiness occur in
the case of overdosage of magnesium
drugs .
Zinc deficiency
- Disorder of oxidative system function;
- Hormonal imbalance;
- Disorder of genome function (is
included in zinc-containing
nucleotides);
- Accumulation of heavy metals;
- Immunologic accumulations, including
allergy;
Selenium deficiency
- Decrease of thyroid gland function;
- Accumulation of toxins and heavy metals
(selenium is antagonist of mercurous and
arsenium; defends the body from
accumulation of cadmium, lead, thallium);
- Decreased energy metabolism (if selenium
participates, 80% of molecules of take part
in Q10 coenzyme synthesis);
- Decreased selenium function;
Molybdenum deficiency
- Increased irritability, hyperactivity;
- Methylation disorder (molybdenum is
included in sulfite oxidase content);
- Inhibition of methionine catabolism;
- Accumulation of copper in the body.
Thus, deficiency of vitamin B, macro- and
microelements is diagnosed in children
with autism and autistic spectrum of
behavior disorder. Normalization of their
level should be individual and then
controlled by blood and urine analysis.
Thanks for your attention!