Transcript 2010_ICR_Vision_for_EAC_(AGM_Talk)

Vision
for the ICR Program (end of 2017)
Maintain and extend world leadership in FT-ICR MS
instrumentation and capabilities:
Highest magnetic field (21 T (also EMSL))
Highest resolution and mass accuracy
New ionization methods
Ion optics
Automation
Data reduction
Orbitrap --possible 2-3x improvement?
Multi-Pass Time-of-Flight--possible 2-3x improvement?
as of summer 2010, mid-point in current award period
Future Fuels Institute
Joint industrial partnerships to establish a rational
molecular-level basis for understanding and predicting the
properties and behavior of petroleum (especially heavy
ends) and biofuels
$250K/year for 4 years initially per Member Company
>80% Publishable (Grad Students/Postdocs)
<20% Proprietary (Staff--Treat as Patent I.P.)
Shell Global
Saudi Aramco
ExxonMobil
Nalco
ConocoPhillips
Sinopec
UOP
Total (France)
PetroChina
Exploratory Biofuels (1-2 year, $50-100K each):
Sapphire Energy, Primus, Solazyme
Petroleomics as a Predictive Tool
Distillation
Hydroprocessing: Chemical Reactivity Modeling
Oil/Water Emulsions
Asphaltene Cracking
Compartmentalization
Petroleomics database: >100,000 cpds from 77 Crudes
Quantitation: HPLC FT-ICR MS (W. Robbins, ex-ExxonMobil)
Distillation: GCxGC 7 T FT-ICR MS (Partner with Zoex)
Pilot Data: 2010-2011
SBIR: 2011
Commercial Instrument 2012
Oil Spill Monitoring
Nalco, Woods Hole, NSF RAPID $$?, BP $$?
Target needs for FT-ICR MS for Biochemistry & Biology
NIH:
H/D Exchange to Map Interfaces in Protein Complexes
Drug Design
Top-Down Proteomics (Human Proteome)
Cell Membrane Lipids/Glycolipids
Metabolomics
Biomarkers
Partners:
Pfizer (Donated ESI/TOF mass spectrometer)
M. D. Anderson Cancer Center
Scripps La Jolla
Northwestern U.
Need Bioinformatics Expert