Transcript Field induced Magnetic Nanoparticle Drug Delivery

Improving Field-Induced
Magnetic Nanoparticle
Drug Delivery
BME 273 Group 15
Team Leader : Ashwath Jayagopal (BME, EE, MATH)
Members : Sanjay Athavale (BME) and Amit Parikh (BME)
Advisor : Dr. Dennis Hallahan, Chairman of Radiation
Oncology and Professor of Biomedical Engineering and
Radiation Oncology, Vanderbilt University
There is a strong rationale for magnetic
nanoparticle related design projects
•Drug Delivery
•Improving noninvasive
medical imaging (MRI)
•Microsensors
•Gene Therapy
The properties of magnetic nanoparticles can
be varied to make a specific recipe
•Diameter
•Coating
•Chemical modifications
Gold-coated iron nanoparticles exhibit
•Absorption, tracer strength
different absorption spectrums for use in
medical imaging
(Chinese Academy of Sciences, 2000)
Our project aims to improve the processes of
magnetic nanoparticle drug delivery
There are several primary concepts involved:
•Magnetic nanoparticle properties (Ga. Tech)
•External field induction design
•Heating and irradiation
•Chemical enhancements
Goal : A process that results in homogenous and local
drug distribution in a variety of tumors
We seek to combine several aspects in order to
enhance magnetofection in tumors
Feasible:
•Microelectromagnet
•Current loop, multi-layered wire matrix
•Heating and irradiation processes
Not possible:
•Alteration of nanoparticle properties
•Chemical purification and coating
There are several obstacles
that demand attention
•Nanoparticle Aggregation
•Tumor Permeability
•Drug Delivery location and duration
•Resources
Controllable?
•Sizing (immune system detection, circulation stability)
•Low energy barrier (for rapid magnetic state changes)
Current Status
•Certification, have met with all relevant VUMC personnel
•Have requested magnetic nanoparticle sample sets of various
properties
•Consulting Dr. Hallahan and other personnel on possibility of
designing a microelectromagnet for our purpose
•Scheduled to observe magnetic nanoparticle mobility
experiments
Future Objectives
•Conduct experiments on mice tumors using nanoparticles
(otherwise using tumor models), once samples obtained
•Open consultation with nanotechnology group at Georgia
Tech
•Begin design of a microelectromagnet “trap” to achieve
homogenous nanoparticle distribution
•Continue consultation with all involved personnel
Current Individual Responsibilities
Ashwath : team leader, directly responsible for reporting
progress to advisor and related personnel. Involved in design
and contacts with related research companies.
Sanjay : Involved in research related to magnetic nanoparticle
drug delivery.
Amit : Patent searching, researching possible methods of
trapping nanoparticles to achieve a desired distribution.