Transcript PPT

Increase in prescribing of systemic tetracyclines
and isotretinoin for treatment of acne vulgaris in
Norwegian adolescents from 2005 to 2014
Ingvild Odsbu1, Randi Selmer2, Cecilia Stålsby Lundborg1 and Hege Salvesen Blix2
1Department
of Public Health Sciences, Karolinska Institutet, Stockholm
2Department of Pharmacoepidemiology, Norwegian Institute of Public Health, Oslo
Aim
To investigate the prescribing of systemic drug therapy
for the treatment of severe acne vulgaris in adolescents
over a 10 year period
Materials and methods
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The Norwegian prescription database
Period 2005 – 2014
Individuals aged 14-24 years
Tetracyclines (doxycycline, lymecycline,
oxytetracycline and tetracycline) and isotretinoin
Treatment of severe acne vulgaris
Systemic tetracyclines
Isotretinoin
Disturbs the normal gut microbiota
Contributes to antibiotic resistance
Gives side effects
Teratogenic
Increase in one-year prevalence
Increase in incidence rate
Conclusions
 Increased prescribing rates observed in the period
2005-2014
 Tetracyclines most commonly prescribed
 Isotretinoin increasingly prescribed
 Tetracyclines: greater increase in prevalence and
incidence of use in women compared to men