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THOMSON REUTERS INTEGRITYSM:
INTEGRATED DRUG DISCOVERY AND DEVELOPMENT PORTAL
THOMSON REUTERS INTEGRITY:
INTEGRATED DRUG DISCOVERY AND DEVELOPMENT PORTAL
Integrity Log On
and
Basic Information Retrieval
Techniques
THOMSON REUTERS INTEGRITY:
INTEGRATED DRUG DISCOVERY AND DEVELOPMENT PORTAL
• Slides 4-7 of this presentation illustrate how to register to use
Integrity and the contents of the Integrity Home Page. The remaining
slides illustrate the basic techniques for retrieving information:
• Slides 8-14
Quick Search
• Slides 15-24 Guided Search (Search Form)
• Slides 25-33 Structure Search
• Slides 34-37 Information retrieval via Targets & Pathways
• Slides 38-43 Information retrieval via Disease Briefings
• Slides 44
Support
THOMSON REUTERS INTEGRITY:
LOG ON AND INTEGRITY HOME PAGE
Take the following steps
to begin consulting the
Integrity drug discovery
and development portal:
Go to http://
integrity.prous.com
(or alternatively, https://
integrity.prous.com for an
SSL connection).
THOMSON REUTERS INTEGRITY:
LOG ON AND INTEGRITY HOME PAGE
Log on by entering your
User Name and
Password and clicking
Login.
This takes you to the
Integrity Home Page.
Note: There is a
Password Reminder
feature for your
convenience.
THOMSON REUTERS INTEGRITY:
LOG ON AND INTEGRITY HOME PAGE
The Home Page
provides access to:
the Knowledge
Areas for running
searches, Quick
Access links to
recent and relevant
content, a Quick
Search utility and
a series of Getting
Started features.
THOMSON REUTERS INTEGRITY:
LOG ON AND INTEGRITY HOME PAGE
Click Getting
Started to access the
FAQs which include
useful definitions and
to access the
Learning Center
which presents key
features and training
opportunities including
Live Sessions, ELearning and Use
Cases
THOMSON REUTERS INTEGRITY:
QUICK SEARCH
You can use the
Quick Search
feature to launch a
broad search across
all Knowledge Areas
of Integrity.
Type a term in the
Quick Search box
and click Go to
launch your search.
THOMSON REUTERS INTEGRITY:
QUICK SEARCH
When the Quick
Search results
display, click any of
the enabled bars
to see results in
that Knowledge
Area, for example,
to see a set of
drugs related to the
search term.
THOMSON REUTERS INTEGRITY:
QUICK SEARCH
From the
Knowledge Area
results display, use
Filter by
Statistics to refine
results or open the
Options pull-down
menu to select from
a variety of display
and data
management
options. Click
Product List with
Structures
THOMSON REUTERS INTEGRITY:
QUICK SEARCH
The Product List
with Structures
display option
facilitates review of
the structureactivity
relationship of
compounds.
Click an Entry
Number to display
an individual
product record.
THOMSON REUTERS INTEGRITY:
QUICK SEARCH
The product record
display provides
general and
chemical
information on
the product…
THOMSON REUTERS INTEGRITY:
QUICK SEARCH
…a Product
Summary, a
Development
Status Summary
and links to
Related
Information in
the other
Knowledge Areas of
Integrity
Click a Related
Information link
to display
information such
as...
THOMSON REUTERS INTEGRITY:
QUICK SEARCH
...Pharmacokinetics /
Metabolism
values, each of
which is
referenced to its
original source.
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
To set up a Guided
Search, go to a
Knowledge Area -Drugs & Biologics
in this example.
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
Click the down
arrow to open the
pull-down of
search fields.
and select one –
Development
Status ->
Condition in this
example.
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
Next open the
Browse Index of
search terms for
the search field
chosen, run a
preliminary lookup
search to locate a
term in the index,
and then click the
term on the right
to copy it to the
Search Form.
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
Add other relevant
criteria to the
Search Form – in
this example, select
Development
Status -> Under
Active
Development = Y
– and click Start to
launch the search.
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
From the list of
active development
programs for
leukemia, you can
retrieve the
corresponding
products selecting
the Product List
from the Options
pull-down menu
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
Use the Filter by
Statistics charts to
further limit your
search. From the
Product List
obtained, filter by
Organization
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
Check the
companies you
are interested in
and click View
Subset(s)
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
Select the Full
Record option
from the Options
pull-down menu
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
The product record
for Imatinib
mesylate shows
that it acts on
multiple targets,
including Abl
Kinase and BcrAbl Kinase
THOMSON REUTERS INTEGRITY:
GUIDED SEARCH (SEARCH FORM)
The product record
for Nilotinib
Hydrochloride
Monohydrate
shows that it acts
selectively on BcrAbl Kinase. To
further investigate
selectivity of similar
compounds a
substructure search
can be run.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
To set up a
structure search,
select a Knowledge
Area – Drugs &
Biologics in this
example – and click
the Structure
Search button to
go to the Structure
Search Form.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
Draw or paste a
structure in the
structure search
window.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
Combine a
substructure search
with a text search
by opening the
search field menu
and selecting a field
- in this example,
Therapeutic
Group.
Then open the
corresponding
Browse Index to
select a term.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
Use the Lookup
box in the Browse
Index to locate
terms in the
hierarchical
Therapeutic Group
index.
Then click a term -Oncolytic Drugs
in this example -to copy it to the
Search Form.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
Click Start or press
Return to launch a
search for products
with this
Therapeutic
Group
classification and
that share a
similar
substructure.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
Compounds can be
classified quickly
and easily by using
Filter by
Statistics. In this
example, select to
filter by Molecular
Mechanisms.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
The chart shows
that many of the
compounds have
more than one
mechanism of
action.
Using the checkbox
function, select
Bcr-Abl Kinase
Inhibitors and
click View
Subset(s) to view
the subset of
compounds with
this mechanism.
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
From the original
list of product
records retrieved
that are Oncolytic
Drugs and that
have a similar
structure, these are
the compounds
that are Bcr-Abl
kinase inhibitors.
Select the Product
List with
Structures from
the pull-down menu
THOMSON REUTERS INTEGRITY:
STRUCTURE SEARCH
From this list,
structure-activity
relationships can
be examined.
Access to
Experimental
Pharmacology,
Pharmacokinetics/
Metabolism and
other data can be
obtained through
the All Related
Information via
Quick Search
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA TARGETS & PATHWAYS
For example, select
the Targets &
Pathways enabled
bar
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA TARGETS & PATHWAYS
From the Targets
& Pathways list
obtained, select the
Targetscapes
option
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA TARGETS & PATHWAYS
Click on the Acute
Myeloid
Leukemia
Targescape…
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA TARGETS & PATHWAYS
… to view the
molecular
landscape for this
condition.
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA DISEASE BRIEFINGS
Click Disease
Briefings from the
Home Page or
select it from the
pull-down menu of
Knowledge Areas
in other pages of
Integrity.
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA DISEASE BRIEFINGS
In the Disease
Briefings
Knowledge Area,
click a category to
display a menu of
related titles and
make a selection.
For instance, select
Leukemia
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA DISEASE BRIEFINGS
Disease Briefings
present information
in a text-based
format accompanied
by multimedia
images.
The Table of
Contents appears
on the left side of
the screen. Click any
block (Morbidity
and Mortality in
the example) to
move to that
chapter.
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA DISEASE BRIEFINGS
Chapters with
arrows have
sections. In the
Treatment chapter,
click a section to
display information
on specific
mechanisms and
compounds acting
via those
mechanisms.
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA DISEASE BRIEFINGS
The “higher-level”
sections present
information on
marketed
compounds...
THOMSON REUTERS INTEGRITY:
INFORMATION RETRIEVAL VIA DISEASE BRIEFINGS
...and the “lowerlevel” sections on
developmental
compounds.
Click any
compound to
display the product
record…
THOMSON REUTERS INTEGRITY:
SUPPORT
For questions about
Integrity’s contents or
features, send a
message via the Help
Request /
Suggestion Form in
Integrity or contact
integritysupport@th
omsonreuters.com