Transcript Intro to systemic enzyme therapy

Introducing
Systemic Enzyme Therapy
Webinar 2016
What Are Enzymes?
Enzymes are protein molecules, composed of long chains of amino acids. Enzymes are the
biocatalysts necessary for the chemical reactions associated with breathing, growth, reproducing,
digestion, and all other metabolic functions.
For most people under the age of 25, enzymes are efficiently produced by the body to maintain
optimal health. As we age, our body’s production of enzymes decreases. This reduction of enzyme
levels may reduce the efficiency of our normal body functions. These enzymes are needed to
maintain a healthy immune system, healthy joints, good circulation, and an overall balanced
reaction to injury.
The older we get, our need for enzyme production increases, while the amount of usable enzymes
in our body is gradually depleted. Enzyme deficiency can lead to a wide variety of health problems.
What Are Digestive Enzymes?
Digestive enzymes work in the digestive tract where they help break down
fats, carbohydrates, and proteins for improved digestive function and nutrient
absorption.
What Are Systemic Enzymes?
Systemic enzymes are those that operate throughout the body in every system
and organ. Following their resorption from the gastrointestinal tract, enzymes travel
to their “site of action” in the body via the bloodstream, where they ultimately
become effective. This is known as the “systemic effect”. The term “systemic”
indicates that the agent (in this case the enzymes) is distributed throughout the
entire body.
Supplementation with systemic enzymes may help the body to more efficiently
regulate the metabolism, thereby reducing the physiological effects of aging.
Physicians in Europe and Asia have long prescribed enzyme supplements to
restore enzyme levels and promote natural healing.
Systemic enzymes are formulated to resist the acidic environment of the stomach
so that they can be absorbed into the bloodstream from the small intestine. Once in
the bloodstream, the enzymes are able to be used throughout the entire body.
Serrapeptase Overview
Serrapeptase is a key ingredient to consider when choosing the right enzyme. To ensure maximum
absorbency without activity loss, an enteric coated delivery system is essential.
Serrapeptase is a naturally occurring, physiological agent with no inhibitory effects on
prostaglandins and is devoid of gastrointestinal side effects. It is a proteolytic enzyme isolated
from the micro-organism Serratia E15. This enzyme is naturally processed commercially today
through fermentation.
Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation
in all forms. The late German physician, Dr. Hans Nieper, used Serrapeptase to treat arterial
blockage in his coronary patients. Serrapeptase protects against stroke and is reportedly more
effective and quicker than EDTA Chelation treatments in removing arterial plaque. He also
reports that Serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Serrapeptase & Inflammation
Enzyme Fights Inflammation
Our bodies have a love-hate relationship with inflammation. On the one hand, inflammation is a
natural response, necessary to protect the body from invading organisms. On the other hand,
inflammation can limit joint function, and destroy bone, cartilage and other articular structures.
An elusive goal of scientists and physicians has been to find a side-effect-free substance to reduce
the pain and inflammation associated with fibrocystic breast disease, rheumatoid arthritis, idiopathic
edema, carpal tunnel syndrome and post-operative swelling. It appears that the search may be
nearing an end, thanks to an enzyme Serrapeptase produced by the larval form of the silk moth.
Serrapeptase is proving to be a superior alternative to the non-steroidal anti-inflammatory agents
(NSAIDs) traditionally used to treat rheumatoid arthritis and osteoarthritis. Its uses have also been
extended to the treatment of chronic sinusitis and postoperative inflammation, and some researchers
believe the substance can play an important role in arterial plaque prevention and removal.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Harmful Effects of NSAIDs
NSAIDs, which include aspirin, ibuprofen, salicylates, and naproxen, are
among the most commonly prescribed medications for inflammation resulting
from rheumatoid arthritis, joint conditions, osteoarthritis, gouty arthritis, joint
and muscle discomfort associated with systemic lupus erythematous, and
other musculoskeletal disorders.(1) In some cases, this overreliance on
NSAIDs has proved deadly. Annually, 76,000 people are hospitalized from
NSAID-induced gastrointestinal complications. The American Medical
Association estimates that from 50-80 percent of those hospitalized for
gastrointestinal bleeding are taking some form of NSAIDs.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
5 Functions of a Systemic Enzyme
Natural Anti-inflammatory
Refers to the property of a Systemic Enzyme formula to reduce inflammation which is a reaction by the
immune system to an irritation that causes redness, swelling, pain, tenderness, heat, and disturbed function
to an area of the body.
Anti-Fibrosis
Refers to the property of a Systemic Enzyme formula to reduce the development of excess fibrin (a fibrous
connective tissue or scar tissue) in an organ in the body.
Blood Cleansing
Refers to the property of a Systemic Enzyme formula to clean excess fibrin and waste materials from the
blood.
Immune System Modulating
Refers to the property of a Systemic Enzyme formula to assist the body to balance the immune system and
to maintain an optimal stable, constant condition.
Virus Fighting
Re Refers to the property of a Systemic Enzyme formula to disrupt, eat away, virus protein cell walls to
inhibit the virus from replicating itself and to render individual viruses inert.
* Source for the Five Functions: ENZYMES: The Fountain of Life, by D.A. Lopez, M.D.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Enzyme Effectiveness
How is enzyme effectiveness determined?
It is by the amount of activity level in the bloodstream after the enzyme has been absorbed from the
small intestine. Enzymes lose activity in low pH (1.0 - 3.0) of the stomach. Studies show that
unprotected enzymes can lose up to 100% of their activity in 30 minutes or less. Enteric coating is
the only reliable method to ensure that 100% of the enzymes are not destroyed, and is by far the
most effective delivery method to prevent release of the enzymes before they reach the small
intestine.
What happens to uncoated capsules and tablets?
Stomach acid breaks down tablets and capsules and prematurely releases active enzymes
(enzymes). The highly acidic environment of the stomach destroys the majority of the enzymes’
activities. If the tablet is of poor quality (contains binders and fillers) the product may pass through
both the stomach and intestine with no absorption.
Delivery Systems
The real differentiator among Systemic Enzymes is in the method of delivery to the stomach
and ultimately to the small intestine. The only method to protect and effectively deliver a
systemic enzyme is a 100% enteric-coated product.
“Protein molecules are normally destroyed (denatured) by the hydrochloric acid of the stomach and
broken down into individual components by the special, acid-proof enzymes of the gastric tract
(pepsin) and the enzymes of the pancreas. For this reason, tablets, capsules, or granules are used
that are enteric-coated or covered with an acid-proof layer. In this way, the enzymes are held safely
until that section of the intestines is reached where their resorption is possible.
The acidity of the gastric juices in this region has long been neutralized. The digestive enzymes
found here have, for the most part, already performed their activities and are primarily inactive. Only
then does the covering of the tablets dissolve. The active enzymes are subsequently released and
can be resorbed into the system through the intestinal wall by way of special transport mechanisms.”
“Enzymes – A Drug of the Future” by Prof. Dr. med., rer. nat. Heinrich Wrba; Dr. med. Otto Pecher
Oral Delivery Systems
1. Powder Filled Capsule
2. Tablet
3. Enteric-Coated Liquid Gel Capsule
Powder Filled Capsule
Powder-filled Capsule Digestion
Vegetarian or Gelatin Capsule. Powder filled capsule technology
is suitable for contents that are not susceptible to the acidity of the
stomach. The capsule and its enzymes are dissolved prematurely
in the stomach, resulting in up to 100% destruction of the
enzymes within 30 minutes in the extremely low pH environment.
Tablet
Tablet Digestion
Enteric-Coated Tablet. Enteric-coated tablets are able to withstand
stomach acids, however, they must be introduced into a high pH
environment for extended periods before dissolving. Since individual
pH levels vary, the tablet may dissolve very late in the small intestine
or bypass it completely. Many users also complain of the synthetic
coating.
Liquid Filled Gel Capsule
Gel Capsule Digestion
Enteric Coated Liquid-Filled Gel Capsule. The all-natural protective
coating prevents the enzymes from being destroyed by the stomach
acids. The pancreatic juices break down the coating in the duodenum.
This makes 100% of the enzyme contents available for absorption
into the bloodstream.
Enteric Coating
Enteric Coating is the best and most effective oral delivery
system today for systemic enzymes. The technology of
enteric coated liquid-filled capsules is superior to that of
powdered enzymes because it uses low heat production,
provides more uniform dose distribution, and prolongs
enzyme activity.
Low Heat Production
Low Heat Production– Powder enzyme blends are available today that use an
enteric coating, but they are in tablet form. The disadvantage of these blends is
the amount of heat created with compressing the ingredients into a tablet.
Enzymes are susceptible to high temperatures and may begin to degrade during
the manufacturing process. Solubilized Liquid-Filled Gel Capsules allow for an
enteric-coated enzyme without activity loss from heat. Temperature ranges during
the production of the Solubilized Liquid-Filled Gel Capsules and the enteric
coating process are strictly controlled to ensure that there is no enzyme activity
loss due to heat that sometimes occurs during the production of enteric coated
tablets.
Optimal Dose Distribution
Optimal Dose Distribution– Liquid enzyme blends provide a more uniform dose
consistency, because the mixing of liquids allows for optimal particle distribution.
In powder formulations, each particle of a different enzyme is different in size,
causing greater friction between particles during mixing.
Excipients are introduced to powder formulations to increase the mix ability, but
liquids still provide far more even distribution of ingredients, allowing for more
consistent dosages in each capsule.
Prolonged Enzyme Activity
Enzymes always retain some amount of moisture when they are produced.
Enzymes as proteins are more susceptible to denaturation at higher moisture
content. Enzyme powders typically have lower (5-10%) moisture content. However,
even with lower moisture content, enzyme powders will lose some of their activity
over time, resulting in a loss of up to 20% of activity over a 12-month period.
Liquid-Filled Gel Capsules contain enzymes with a higher degree of purity and less
moisture that when combined with Medium-Chain Triglycerides (MCT), then
decompressed during the manufacturing process, removes the moisture completely.
As a result, loss of enzyme activity over time due to moisture will not occur.
Systemic Enzyme Therapy
A well balanced Systemic Enzyme supplement should have a unique blend of
enzymes, flavonoids, and antioxidants.
Other Key Features:
Minimal Dosage Required for Maximum Benefit
Solubilized Liquid Filled Gel Capsule
All Natural, Vegetarian Formula
Low Heat Production
100% Absorption into the Small Intestine
Optimal Distribution
Greater Patient Compliance
Prolonged Enzyme Activity
Higher Potency & Purity
Advanced Delivery System - Enteric Coated Liquid Filled Gel Capsule
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Systemic Enzymes Exclusively for Healthcare
Practitioners Like You
There are thousands of enzymes available on the market today
through retail stores and online resellers but choose an unique
blend of vegetarian enzymes, flavonoids and antioxidants with
100% absorption and pharmaceutical strength available
exclusively through healthcare practitioners like you.
No need to compete with the internet after educating your
patients on the importance of enzyme therapy.
Pharmaceutical strength systemic enzymes that are enteric
coated and liquid filled offer more potency and less dosage
meaning better patient compliance.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure
or prevent any disease.
Serrapeptase -
Ingredients in a Well Balance
Systemic Enzyme
Is one of the most popular enzymes available.
Protease Any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process
known as proteolysis. *
Bromelain Found in pineapples and breaks down other proteins, such as collagen.*
Papain A proteolytic enzyme obtained from un-ripe papaya.*
Amylase Digests carbohydrates and helps convert starch to sugar. *
Lipase Digests fat. It is secreted in the digestive tract that catalyzes the breakdown of fats into individual fatty acids that can
be absorbed into the bloodstream. *
Amla -
Is a great source of Vitamin C.
Rutin –
One of the many existing flavonoids and supports health by supporting capillaries and other
connective tissue.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Disintegration and Activity Tests;
What Do They Mean?
The disintegration test consists of two conditions to
see if a capsule will dissolve correctly.
Test 1:
Simulates Stomach Conditions
– disintegration in this test will expose
enzymes to acidic conditions.
Disintegration=Failure
Test 2:
Simulates Intestinal Conditions
– disintegration in this test will enable
enzyme release for absorption in the
small intestine.
Disintegration=Pass
Test #1 shows that when a
capsule not enteric coated was
exposed to an acidic
environment resembling the
stomach, the enzyme activity
was prematurely released with
no activity remaining to pass
through to the small intestine.
Test #2 shows that when a
capsule remains intact because
of enteric coating and it
reaches the small intestine, it
then breaks down completely
and is absorbed at the right
time.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
What Does an Activity Test Show?
The activity test consists
of two differing conditions:
Test 1:
Simulates Intestinal Conditions
– activity level of product in ideal
conditions.
Test 2:
Simulates Stomach Conditions
– activity level if exposed to harsh
acidic environment (i.e. stomach)
Test #1 looks at the enzyme activity
of a capsule when exposed to the
small intestine where it should
breakdown for maximum benefit.
Test #2 looks at enzyme activity
when a capsule is exposed to an
acidic condition similar to the
stomach and shows that if not
enteric coated or protected, it will
break down prematurely.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Disintegration & Activity Test Results Mean...?
Using the certificates of analysis together; can determine if
a product will have its maximum activity level intact
when/if a capsule dissolves in the intestinal tract.
 So, if a capsule failed the disintegration test, it will have much lower
activity levels due to it being exposed to acidic conditions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Important Features –
Choosing the Right Systemic Enzyme
FULLY ENTERIC COATED CAPSULE
-
Capsules that have a full USP (pharmaceutical grade) enteric coating for ease of swallowing and to ensure a
more complete delivery of the product and more assured release. You can expect to receive 100% absolute
consistency with every capsule.*
LIQUID FILLED GEL CAPSULE Better consistency, higher potency, more concentrated, greater purity, and unparalleled absorption.*
SMALLER CAPSULES Better compliancy.*
SMALLER DOSES – FEWER DOSES The combination of the items listed above bring with them just one thing – POTENCY. Fewer capsules really
can bring more benefit.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure
or prevent any disease.
Systemic Enzyme Supplements
Clinical studies are important and are a critical component when designing and developing a
supplement. However, clinical studies are generally limited to the ingredients used in a formula.
When choosing the right enzyme supplement, look for one that only uses ingredients that have
solid clinical evidence supporting their efficacy and safety. It is important to examine these
ingredients at a molecular level to determine their compatibility and synergy with other ingredients
in the formula. This is important because when you mix ingredients they can interact with each
other to form a different compound. If ingredients are combined scientifically their individual
effectiveness can be increased exponentially.
Virtually no manufacturer conducts clinical studies on their finished products. This is because of
the cost which can run into millions of dollars and unlike a synthetic pharmaceutical product which
can enjoy patent protection there is no such protection with natural products. Another reason is
science is moving very fast in the area of supplementation.
The understanding of nutrition both internally and externally continues to increase and new active
ingredients are continually developed to improve the efficacy of products. So, even if it was
practical to conduct a clinical study on a supplements it is likely it would be out of date before the
final report was completed.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
A Preliminary Trial of Serrapeptase
in Patients with Carpal Tunnel Syndrome*
Panagariya A, Sharma AK
Dept. of Neurology, SMS Medical College and Hospital, Jaipur.
J Assoc Physicians India 1999 Dec;47(12):1170-2

OBJECTIVES: This study was planned to assess the response of Serrapeptase in patients with carpal tunnel syndrome
(CTS).

METHODS: Twenty patients with CTS were evaluated clinically. After baseline electrophysiological studies, these
patients were given serrapeptase 10 mg twice daily with initial short course of nimesulide. Clinical and
electrophysiological reassessment was done after 6 weeks.

RESULTS: Mean age was 43.9 years with male to female ratio of 1:2.33. Sixty five percent cases showed significant
clinical improvement which was supported by significant improvement in electrophysiological parameters. Recurrence
was reported in four cases. No significant side effect was observed.

CONCLUSIONS: Serrapeptase therapy may prove to be a useful alternative mode of conservative treatment. Larger
study may be further helpful to establish the role of Serrapeptase in CTS.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Take Heed...
Systemic enzymes may help rid the body of toxins. Some users
will experience a detoxification reaction to the enzymes,
including short-term fatigue, nausea, fogginess or headache.
Though uncomfortable, detoxification is beneficial to the body.
Increased water intake can assist in the process, or a reduction
in the enzyme dosage will slow the rate of detoxification. If
symptoms persist, a patient should contact his or her healthcare
professional.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
Thank You for Learning About
Systemic Enzyme Therapy
Please contact World Nutrition, Inc. at
(800) 548-2710 if you have any questions.
www.WorldNutrition.net
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