Transcript Inhaled Therapeutics using Dry Powder Inhalers (DPI)

Inhaled Therapeutics using Dry Powder
Inhalers (DPI)
Scott Selig ‘19 Biomedical Engineering
Intro: Common Lung Diseases
which compromise Airflow
Asthma- inflamed airways and shortness of breath
Chronic Obstructive Pulmonary Disease (COPD)- inability to exhale normally
Chronic Bronchitis- a type of COPD categorized by a chronic cough
Emphysema- Lung damage prevents lungs from fully exhaling
Cystic Fibrosis- genetic condition causing poor clearance of mucus from the
bronchi
"Lung Diseases: Types and Causes of Common Conditions." WebMD. Ed. Varnada
Karriem-Norwood. WebMD, 23 Mar. 2014. Web. 31 Oct. 2015.
Intro: Problems with Medicating Targeted
Area using an Inhaler
Patient’s inability to administer dosage from
device
Patient’s shortness of breath
Device’s limitations: variable delivered doses
and inhaler design issues
Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus
Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy
Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31
Oct. 2015.
Intro: Advantages of Dry Powder Inhalers
(DPIs)
Device’s reliability
Carrier particle’s high ability to disperse
Device’s drug dosage accuracy
Carrier particle’s high drug yield
http://www.capsugel.com/ihc/drypowder-inhaler-capsules
Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus
Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy
Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31
Oct. 2015.
Method: Testing the Design of the
Autohaler™
Observational Study of the interface of the device with patients 6 to 18 years of age
- Compared dry powder inhaler (DPI) to metered dose inhaler (MDI) with spacer
- Looked at the ability of the patient to correctly give the proper dosage
- Looked at how easily the device was used
Autohaler
-
multi-dose DPI
http://www.mikesouth.org.au/Asthma
_devices/MDIs/album/slides/airomir
%20autohaler.html
http://www.wikihow.com/Use-an-Inhaler
Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus
Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy
Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31
Oct. 2015.
Result: Testing the Design of the
Autohaler™
The patients who used the breath
actuated DPI (Autohaler) had
better control of their asthma and
received the desired dosage when
needed with fewer dosage
technical difficulties.
Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus
Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy
Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31
Oct. 2015.
Method: Testing different blends of Lactose
Coarse Carrier Particles with varying levels
of Fine Lactose
- Three different blends of different grade
lactose supplement with different levels of fine
lactose were used
- Using three different DPIs (Aeroliser,
Handihaler, and Rotahaler), the different
grades of lactose blends were tested for their
in vitro particle distribution and drug
deposition
Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and
Ben Forbes. "Interaction of Formulation and Device Factors Determine the In
Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of
Pharmaceutical Sciences J. Pharm.
Method: Testing different blends of Lactose
Coarse Carrier Particles with varying levels
of Fine Lactose
Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and
Ben Forbes. "Interaction of Formulation and Device Factors Determine the In
Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of
Pharmaceutical Sciences J. Pharm.
Method: Testing different Dry
Powder Formulations
Sympatec laser diffraction to
determine particle size and shape
www.sympatec.com
Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and
Ben Forbes. "Interaction of Formulation and Device Factors Determine the In
Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of
Pharmaceutical Sciences J. Pharm.
Results: Testing different Dry
Powder Formulations
(a) LH200 (b) ML001 (c) ML006
(white) Aeroliser (black) Handihaler (stripes) Rotahaler
Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus
Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy
Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31
Oct. 2015.
Result: Testing different Dry Powder
Formulations
The amount of fine lactose added
to the varying types of coarse
lactose tended to increase fine
particle fraction (FPF), directly
relating to an increase in drug
deposition.
Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus
Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy
Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31
Oct. 2015.
Discussion: Pulmatrix iSperse™
- iSperse is an alternative to traditional dry powder lactose
bases, which can be mixed with a variety of different
medications
- The powder is primarily a calcium salt base claimed to be
easily dispersible and very dense, resulting in high yield of
drug deposition in the lungs
http://bionews-tx.com/news/2014/05/14/pulmatrix-cystic-fibrosis-isperse-antibiotics/
Lipp, Michael M., and Jean C. Sung. Respirably Dry Powder Comprising Calcium
Lactate, Sodium Chloride and Leucine. Patent 8,992,983. 31 Mar. 2015. Print.
Any questions?
[1] "Lung Diseases: Types and Causes of Common Conditions." WebMD. Ed. Varnada
Karriem-Norwood. WebMD, 23 Mar. 2014. Web. 31 Oct. 2015.
[2] Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose
Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and
Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.
[3] Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben
Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of
Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J.
Pharm. Sci. 104.11 (2015): 3861-869. Pubmed. Web. 31 Oct. 2015.
[4] Holz, Olaf, H. Biller, M. Mueller, K. Kane, M. Rosano, J. Hanrahan, D. L. Hava, and J. M.
Hohlfeld. "Efficacy and Safety of Inhaled Calcium Lactate PUR118 in the Ozone Challenge
Model - a Clinical Trial." BMC Pharmacology and Toxicology BMC Pharmacol Toxicol 16.1
(2015): n. pag. Web. 31 Oct. 2015.
[5] Lipp, Michael M., and Jean C. Sung. Respirably Dry Powder Comprising Calcium Lactate,
Sodium Chloride and Leucine. Patent 8,992,983. 31 Mar. 2015. Print.