Transcript Hepatitis D

Epidemiology and Prevention
of Viral Hepatitis A to E:
Hepatitis D (Delta) Virus
Division of Viral Hepatitis
Hepatitis D (Delta) Virus
d antigen
HBsAg
RNA
Geographic Distribution of HDV Infection
Taiwan
Pacific Islands
HDV Prevalence
High
Intermediate
Low
Very Low
No Data
Hepatitis D - Clinical Features
• Coinfection with HBV
severe acute disease
– low risk of chronic infection
–
• Superinfection on top of chronic HBV
– usually develop chronic HDV infection
– high risk of severe chronic liver disease
HBV – HDV Coinfection
Typical Serological Course
Symptoms
ALT Elevated
Anti-HBs
IgM anti-HDV
HDV RNA
HBsAg
Time after Exposure
Total anti-HDV
HBV – HDV Super-infection
Typical Serological Course
Jaundice
Symptoms
Total anti-HDV
ALT
HDV RNA
HBsAg
IgM anti-HDV
Time after Exposure
Hepatitis D Virus
Modes of Transmission
• Percutanous
exposures
injecting
drug use
• Permucosal exposures
sex
contact
Hepatitis D - Prevention
• HBV-HDV Coinfection
– Pre or postexposure prophylaxis to prevent
HBV infection (HBIG and/or Hepatitis B
vaccine)
• HBV-HDV Superinfection
– Education to reduce risk behaviors among
persons with chronic HBV infection