Transcript الشريحة 1

PAPULOSQUAMOUS
DISORDERS
DR. HADAF A. HASAN
LICHEN PLANUS
A common, pruritic, inf. Disease of skin,
mucosa & hair follicles.
Aetiology: 1)immune: association with
autoimmune disorders & graft vs. host dis.
2) drugs: as gold, antimalarials, thiazides,
anti-TB, sulphonamide & others.
3) ass. With chronic active hepatitis &
hepatitis B,C.
4) Color developers.
Presentation of L.P
Characteristic; almost pathognomonic primary
lesions: small, violaceous, flat-topped, polygonal
papules.
Erythema. then violaceous, then hyperpigmented
Glistening dry surface with whitish streaks or
puncta (wickham stria)
Sites: flexor wrists, med. Thighs, trunk, shins,
dorsal hands & glans penis.
Positive Koebner, prominent itching
Lichen planus
Mucous membrane involvement:
50% of patients, asymptomatic
White lacy lines & dots, or small plaques
Usually inside cheeks, lips
Sometimes may be the sole manifestation
(oral LP)
Genital mucosa may show same picture
Lichen planus
Nail changes:
In 5-10% of patients
May be the only manifestation esp. children
Longitudinal ridging, splitting , onychlysis,
red lunula
Pterygium formation is characteristic of LP
Clinical types of LP
1) Linear: one band or streak, children more
2) annular: 90% are males, axillae &
genitalia, asymptomatic, few lesions.
3) Hypertrophic: mostly shins, verrucous
plaques + scales.
4) Ulcerative: rare on skin, more on mucous
membrane, on sole give bullae + ulcers+
permanent toenail loss
Clinical types of LP
5) Follicular (lichen planopilaris): 70-80% are
females leading to scarring alopecia.
6) Actinic LP: mostly middle east, sun
exposed skin, in spring or summer.
Adolescents & young adults
Face is target organ; forehead, cheeks, lips
Annular, hyperpigmented plaques+
hypopigmented margin, minimal itching.
Histopathology of LP
1)Interface dermatitis along DEJ leading to
destruction of basal layer.
2) A saw-tooth hyperplasia of epidermis+
beaded hypergranulosis.
3) A band-like inflammatory infiltrate in the
superficial dermis of lymphocytes &
macrophages.
Civatte bodies: necrotic keratinocytes in
superficial dermis
Differential diagnosis of LP
Skin lesions:
from lichenoid drug rashes, guttate
psoriasis, lichenoid syphilid, pit. rosea.
Mucosal lesions:
From leukoplakia, candidiasis, oral LE, oral
pemphigus, syphilitic mucous patches
Lichen planus course
Individual lesions may last months
The disease itself may last for 1 year
Hypertrophic lesions are more chronic
Hyperpigmentation usually follow resolution
Recurrence rate is 1 in 6
Treatment of LP
May be difficult
1)Limited lesions by superpotent topical or
intralesional steroids
2)Systemic steroids in certain cicumstances:
Extensive lesions, nail destrucion, painful erosive
oral lesions.
3)phototherpy: PUVA+ narrow-band UVB
4)Retinoids: in hypertrophic types
5) Antihistamines to relieve itching
Oral LP management
Superpotent steroids in orabase or gel form
Intralesional steroids may be given for focal
unresponsive lesions
0.1% tacrolimus ointment is now the
standard treatment for erosive LP of oral &
genital mucosa.
PITYRIASIS ROSEA
Mild inflammatory exanthem characterized
by pinkish, macular,& papular lesions; 1st
discrete, then confluent.
Mainly children & young adults.
More in spring & autumn
Women more than men
Herpes virus 6 & 7 implicated in etiology
Not contagious, 2% recurrence rate
presentation
Begin with herald patch which is larger,
redder, more scaly than remaining rash
Which consist of oval or circinate patches
covered with dry, crinkled, surface,
desquamates leaving a collarette scale
Mainly trunk, extremities, neck
Inverted Christmas tree pattern
Mild pruritis & constitutional symptoms
Clinical types of P.R
Papular PR more in children under 5 years
Inverse P.R opposite sites of predilection
Purpuric type with purpura & ecchymosis at
sites of typical P.R
Last 2-10 weeks & resolves spontaneously
leaving sometimes a post inflammatory
hyper pigmentation
DIFFERENTIAL DIAGNOSIS
P.R may closely resemble:
Tinea corporis, pityriasis vesicolor,
secondary syphilis, seborrheic dermatitis,
drug rash , scabies, viral exanthem, lichen
planus & psoriasis
Treatment
Most cases no treatment is required
To shorten the course or decrease itching:
UVB in erythema doses
Corticosteroids are the standard therapy
Oral antihistamines
Emollients to relieve dryness & irritation
Erythromycine 250mg q.d.s for 2 weeks
Reactive erythema
erythema multiformi
A reaction pattern of multiform erythematous
lesions. May be precipitated by certain factors:
Viral: preceding oral HHV 1-2 weeks previously,
also orf, mycoplasma, hepatitis A,B,C.
bacterial, fungal, & parasitic infection.
Drugs: sulfa, NSAID, anticonvulsants, & others
Pregnancy
Malignancy or its treatment with radiotherapy
Presentation of erythema multiformi
Sharply marginated, erythematous macule.
Become raised edematous papules over 2448 hours.
A ring of erythema forms around the
periphery, with flatter, purpuric dusky
center, giving” target lesions” of 3 zones
Bilateral, symmetrical, & acral distribution
Mostly starting on dorsa of hands
Presentation of E.M
Sites of predilection are extensor limbs,
face, elbows, knees, palms & soles.
Oral mucosal involvement in 25% of cases
Stevens-Johnson syndrome is a severe
variant with bullous lesions, fever &
extensive mucosal involvement.
May be complicated by asphyxia, blindness
Treatment of E.M
Most cases are self-limited with symptomatic
treatment.
Remove precipitating factors.
Recurrent HHV infection may be prevented by oral
acyclovir 200mg 3-5 times/day.
Steven-Johnson may require aggressive
treatment: I.V. gamma globuline, good nutrition,
fluid & electrolyte balance, prevent secondary
infection,+ high dose short course systemic
steroids & good nursing care for eyes & mouth.
Erythema nodosum
Inflammation of subcutaneous fat
(panniculitis), elicited by many factors:
1) Bacterial infection: as T.B, strept.,
brucella, leprosy, yersinia.
2) viral, mycoplasma, rickettsia,& chlamydia
3)Fungal as coccidiomycosis
4)malignancy, sarcoidosis, ulcerative colitis,
Behcet disease
5)drugs: sulfa & oral contraceptives.
Presentation of erythema nodosum
Characteristic lesion is a tender red nodule ,
alone or grouped on shins or forearms.
Other areas as thighs, face, breast.
Bilateral, symmetrical lesions.
Mostly in young adult women.
Acute onset, frequently with const. symp.
Resolve within few days leaving bruise like
Course last 6-8 weeks
Investigations & treatment
Thorough history +physical examination
Chest x-ray, throat culture, ASO titre
Treatment is simple consisting of bed rest,
NSAID as aspirin, indomethacin, ibuprofen
Systemic steroids not used
Potassium iodide in a dose of 400-900
mg/day but not for more than 6 months