Transcript OSMA - George Washington University

Planar Microelectrode Arrays
Hardware, Software & Algorithms
New Tools for Drug Discovery
Tom Manuccia
Professor
Department of Electrical & Computer Engineering
George Washington University
202-994-9298
[email protected]
• DESCRIPTION:
– Build high throughput system to detect effects of drugs under development on the firing patterns of
nerve cells grown in culture. Build the system around a new type of microelectrode array developed in
my lab over the past 5 years.
• NEED:
– Huge market. Every candidate compound must be extensively tested for neurotoxic effects.
• STATE-OF-THE-ART:
– All sequential experiments - One drug, one concentration, no simultaneous control
• INNOVATION:
– 96 or more simultaneous toxicology experiments possible using Optically Switched Microelectrode
Array (OSMA) technology - Vastly increased throughput
• PROJECT SCOPE (1st three years):
– Build 3 prototype systems (hardware, software & consumables) & install in selected beta test sites
• MARKET
– Estimated Market Size (next 10 years): 10 systems in each of the 10 largest pharmaceutical labs
– Pricing: Other high throughput testing systems giving similar value added sell for $5 M each.
– % Market Capture: Zero for 1st 3 years; 10% per year thereafter
» Source of market estimates: Meetings with VP level staff at Glaxo, Merck, J&J, & Eli Lilly
– Cost of Production (incl. amortized R&D costs): $1 M / system
» Source of research, development and production cost data: Actual expenditures from my lab