Transcript Pulmonary Embolism Extraction Catheter Development

Pulmonary Embolism Extraction
Catheter Development
Trip Cothren
Lauren Nichols
Dustin Temple
Advised by: Dr. Michael Barnett, VUMC
Cardiology
Problem
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There are over 600,000 cases of
pulmonary embolisms annually in the
United States, which result in nearly
60,000 fatalities.
Systemic thrombolytics can be dangerous
Need a catheter that can quickly and
effectively remove pulmonary embolisms
Goals
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The goal of this project is to design a catheter that
can efficiently remove an embolism from the
pulmonary artery. The main goals of the project are:
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To research and evaluate current technology in pulmonary
embolism extraction
To design a catheter that can successfully remove
embolisms percutaneously and completely without damage
to the patient
To produce a feasible prototype of our design
Our Design
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Combined ideas from multiple existing
medical products
• Inferior vena cava filter
• Absorbable hemostat
• Local clot busting drug administration
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Security from multiple backups
Filter
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Based off inferior vena
cava filter
Umbrella-like device
Expandable to various
sizes
Use of Nitinol
Nitinol
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Different Nickel/Titanium composition
Can be easily annealed and set
Is used in orthodontics
Biocompatible
Advantageous price and strength
Preliminary CAD
Surgicel or Gelita
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Material that attracts clots
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Coat prongs of filter
Prevent clots pieces
from going downstream
Made by Ethicon
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• Oxidized cellulose polymer
• Used clinically for over 50 years
Trellis Catheter Device
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Inflatable back-end
“clot-catching” device
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Local drug delivery
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Use of guide wire
Design Parameters
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Approximately 2 m in length
Umbrella-like filter that deploys from tip
Device expands to15 mm in diameter
Clot attracting material coating filter
Local thrombolytic injection to break up
clot
Function Parameters
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Time frame of < 1 hr
Embolus located via x-ray angiography
Typically done by interventional
radiology or cardiothoracic
For use when systemic thrombolytics are
not viable option
Potential Problems
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Hemolysis causes release of adenosine
when cells lyse
Bradycardia or heart failure
Renal failure
Unpredictable thrombolytic tolerance
Mechanical damage to vessel wall
Current Work
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Decide local
thrombolytic elution
Choose best type of
Surgicel or Gelita
Develop Nitinol usage
Refine model using
Pro Engineer
Future Work
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Meet with Dr. Barnett and Dr. Bream to
discuss feasibility of ideas
Calculate force of push of memory wire
against vessel wall
Ensure biocompatibility of all materials
Meet with Ethicon sales representative
References
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http://www.medgadget.com/archives/img
/sidcath.jpg
http://www.socalcardiology.com/media/a
ngiojet.jpg
http://www.lexmed.com/images/cathphot
o2.jpg