Transcript NIAID Commitment to Influenza Research and Presparedness by

NIAID Commitment to
Influenza Research and
Preparedness
F. Gray Handley
Associate Director for
International Research Affairs
National Institute of Allergy and
Infectious Diseases
National Institutes of Health
January 28-31, 2007
U.S. Department of Health and
Human Services
U.S. Department of Health and Human Services
The
Secretary
Deputy Secretary
Administration for
Children and Families
(ACF)
Administration on
Aging
(AoA)
Food and Drug
Administration
(FDA)
Centers for
Medicare and
Medicaid Services
(CMS)
Agency for
Health Care Policy
and Research
(AHCPR)
Indian Health
Services
(IHS)
Centers for
Disease Control
and Prevention
(CDC)
Agency for Toxic
Substances and
Disease Registry
(ATSDR)
Substance Abuse and
Mental Health Services
Administration
(SAMHSA)
Health Resources
and Services
Administration
(HRSA)
National Institutes
of Health
(NIH)
Program Support
Center
(PSC)
National Institutes of Health
Office of the Director
National Institute
on Aging
National Institute
o Alcohol Abuse
and Alcoholism
National Institute
of Allergy and
Infectious Diseases
National Institute
of Arthritis and
Musculoskeletal
and Skin Diseases
National Cancer
Institute
National Institute
of Child Health
and Human
Development
National Institute on
Deafness and Other
Communication
Disorders
National Institute
of Dental and
Craniofacial
Research
National Institute
of Diabetes and
Digestive and
Kidney Diseases
National Institute
on Drug Abuse
National Institute
of Environmental
Health Sciences
National Eye
Institute
National Institute
of General
Medical Sciences
National Heart,
Lung, and Blood
Institute
National Human
Genome Research
Institute
National Institute
of Mental Health
National Institute
of Neurological
Disorders and
Stroke
National Institute
of Nursing Research
National Institute of
Biomedical Imaging
and Bioengineering
National Center
for Complementary
and Alternative
Medicine
Fogarty
International
Center
National Center
for Research
Resources
National Library
of Medicine
National Center on
Minority Health and
Health Disparities
Clinical Center
Center for
Information
Technology
Center for
Scientific Review
NIAID Basic Research on
Influenza
 Viral replication and evolution
 Host-virus interactions
 Mechanisms and sites that stimulate immune
response
 Immune correlates of protection related to
seasonal influenza vaccination
 Modeling the dynamics of influenza
transmission in large human populations
 Sequence analysis of the 1918 pandemic
virus and its impact on human immune
response
http://www.niaid.nih.gov/dmid/genomes/mscs/influenza.htm
NIAID Influenza Reagent
Repository
 Managed by BEI Resources
 Makes reagents available to all registered
researchers (including international) at no
charge (shipping and handling fees only)
 Influenza reagents currently available:





Purified H and N proteins
Poly and monoclonal antibodies
Influenza virus isolates
Peptide arrays designed for epitope mapping
Antiserum including human serum from H5
vaccinees
Register at: www.beiresources.gov
H5 Influenza Plans Underway in
SE Asia
 Increase training for investigators in SE Asia
in areas related to clinical research and data
management
 Support seroprevalence H5N1 studies in
China and Vietnam through NIAID’s CIPRA
program and in collaboration with AFRIMS.
 Develop research studies to examine crossreactivity of H5N1 strains and molecular
characterization of strains.
 Funding in FY06: $18 Million.
Opportunities for Expanded
Research Cooperation
 Global networks focused on basic,





translational, therapeutic, vaccine
research
Viral characterization and ecology
studies (human and animal)
Training in all areas
Seroprevalence studies
Cooperative sequencing of strains
Bioinformatics to facilitate access to
sequence data and analysis tools
globally and equitably
Key Funding Links
 Collaborative projects involving investigators and institutions from
international sites and the U.S. are particularly encouraged.
 NIAID has a long-standing interest in and commitment to global health and
international research.
 Topics of interest for this program are limited to research on infectious diseases,
including emerging infections that are of the greatest public health significance within
the overseas country (e.g. tuberculosis; malaria; HIV/AIDS; sexually transmitted
diseases; diarrheal, respiratory, and enteric diseases; viral hemorrhagic fevers; viral
encephalitides; parasitic diseases; and vector-borne diseases).
 Development of immunological, microbiological, biostatistical, epidemiological, and
clinical research capacity is encouraged. Studies may be proposed on any aspect of
infectious diseases (except clinical trials), including but not limited to: the
epidemiology, pathogenesis, immunopathogenesis of infectious diseases;
epidemiologic studies to define the incidence, clinical presentations, and outcomes of
diseases; identification of resistance patterns; characterization of susceptible cohorts
for a particular pathogen; pilot and feasibility studies in preparation for larger studies.
 http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-06-041.html
 http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html
For further information contact Karen Lacourciere: [email protected]