Transcript Q:A Patient requiring some antibiotic for his recent infection is

General PrincipleAntimicrobial Chemotherapy
C
C-Competency based questions
Which Competencies? –refer syllabus
1. Questions 1-3: For each of the following
questions, select the most appropriate principle
which describes the statement. Answers may be
used more than once.
(A) Selective Toxicity
(B) Antibiotic Activity
(C) Minimum Inhibitory Concentration
(D) Post Antibiotic Effect
(E) Transferrable Resistance
1. Microbial death which occurs in the absence
of detectable antibiotic.
D
2. Products of Penicillium spp. molds which are
able to kill Staphylococci.
B
3. Due to microbial conjugation.
E
2. Questions 4-6: For each of the following
questions, select the most appropriate
chemotherapeutic agent which describes the
statement. Answers may be used more than
once.
(A) Vancomycin
(B) Ketoconazole
(C) Penicillin V
(D) Amphotericin B
(E) Tetracycline
4. A fungicidal compound
D
5. Prevents aminoacyl tRNA from binding the
30S ribosomal subunit.
E
6. Useful for treating resistant Staphylococcal
infection.
A
3. The following is considered a typical
mechanism by which resistance emerges
in bacteria
(A) Aggregation of enterococcal
bacteria
(B) Induction of membrane-bound
efflux transporters
(C) Alteration of membrane
phospholipid content
(D) Transfer of chromosomal DNA
(E) Dessication of anaerobic bacteria
4. The following is a situation in which the
use of antimicrobial combination therapy is
LEAST justified
C
(A) Polyinfection
(B) Emergence of resistance
(C) Empiric therapy for a lifethreatening infection
(D) Mycobacterium spp. infection
(E) Prophylaxis prior to dental surgery
5. The following combination of antimicrobial
agents is inappropriate
(A) An aminoglycoside and a penicillin
(B) Amphotericin B and Flucytosine
(C) Isoniazid and Rifampin
(D) Chloramphenicol and a
cephalosporin
(E) Neomycin and Polymyxin B
6. Selection of an appropriate antimicrobial agent
should NOT be based on the following factor
(A) Antimicrobial activity
(B) Pharmacokinetics
(C) Adverse effects
(D) Cost
(E) Drug accumulation
Q:A Patient requiring some antibiotic for
his recent infection is diabetic and
immunocompromised. Strategically
Which type of drug will you give him
emperically?
[Clue:Remember pt doesn’t have significant
contribution of immunity to fight against the
invading organism]
C
Relevant Slide No-37(Chapter1)
• Following the treatment of an oral abscess with
clindamycin, a patient develops a greenish, foulsmelling watery diarrhea with left lower quadrant
pain. Other signs and symptoms include fever,
leukocytosis, and lethargy. If the toxin produced by
Clostridium difficile is detected in the stool, the
patient would most appropriately be treated with
[Clue:what is that syndrome known as and which kind
of drug cause this? What is the back up drug for
this?]
A. cisapride
B. gentamicin
C. loperamide
D. metronidazole
E. sulfasalazine
C
Relevant Slide No-48
(Chapter1)
• A patient treated for months with large doses of oral
broad spectrum antibiotics would be most likely to
develop which of the following?
• [Clue:Think, has broad spectrum antibiotic has anything
to do with intestinal flora which causes decreased
absorption of one vitamin which is responsible for
synthesis of some clotting factors?]
A. Bleeding in joints
B. Bony abnormalities
C. Decreased night vision
D. Neurologic deficits
E. Scurvy
C