Transcript Phase III Clinical Trial

Dialog Graduate Education Program
Allison Evatt
MLIS Consultant
Thomson
• Thomson Scientific
– Dialog, DataStar, Derwent, ISI Web of Science, Thomson Innovation
• Thomson Healthcare
– Micromedex, Medstat, PDR, Solucient
• Thomson Financial
– Thomson ONE, Datastream, TradeWeb
• North American Legal
– Westlaw, Findlaw, Elite, Carswell
• International Legal & Regulatory
– Sweet & Maxwell, Aranzadi, Compumark
• Thomson Tax & Accounting
– RIA, PPC, FastTax, Checkpoint, Creative Solutions
Thomson-Reuters
• Proposed acquisition of Reuters by Thomson is under regulatory
review.
• Decision expected by second quarter 2008.
• Primary changes would be in financial business unit.
Over 30 Years
Of Information Excellence
Leading provider of scientific data and business information since
1972.
Dialog pioneered online information services:
earliest system completed in 1967 at Lockheed
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DIALOG File 202: Information Science Abstracts
(c) Information Today, Inc. All rights reserved.
Terminal users manual-army electronic warfare information system (aewis):
dialog online retrieval system.
Book Title: Final Technical Report.
Author(s): Cox, Douglas J
Publication Date: 1972
Project dialog is the culmination of six years of research in information storage
and retrieval conducted by the information sciences laboratory of the lockheed
palo alto research laboratory. The dialog system offers the user an interactive
command language with which he can direct the data processing power of a computer
to assist him in the retrieval of information. By eliminating intermediaries and placing
the user in direct communication with the computer, results are available in seconds
or minutes instead of days or weeks, and interesting avenues of exploration suggested
by preliminary results can be pursued without time lapse. Dialog commands provide
means for describing a search interest to the computer, for obtaining displays
(and printouts) of results, and for redefining a search interest based on examination
of intermediate results. By dynamically partitioning the information store, the user can
rapidly and efficiently converge on a relevant set of documents.
The interface may have changed since 1972,
but one thing remains the same: YOU ARE IN
CONTROL!
When using command language on Dialog, you
are in control of your search. Searching is
precise yet flexible.
Accurate and Authoritative Information
Dialog is the broadest and deepest information resource available:
• More than 600 databases
• 15 terabytes of data
• 65+ billion records
• Over 200,000 unique sources…
…distributed online and through company intranets,
extranets and portals worldwide.
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Accurate and Authoritative Information
Dialog is the broadest and deepest information resource available:
• Scientific, technical, and medical data
• Intellectual property
– Patents, trademarks, copyrights
• News
– Newspapers and magazines
• Business information
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Directories
Financials
Trade publications, newsletters
Market research
Analyst reports
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Accurate and Authoritative Information
• Content selected by teams which check for validity of
information, types of sources, and potential audiences for that
content.
• Searches include retrospective information.
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Patents: 1951+
Engineering: 1884+ (EI Compendex), 1898+ (INSPEC)
Dissertations: 1861+
Chemical data: 1771+ (BEILSTEIN)
Sciences: 1864+ (Zoological Record Online)
Newspapers and magazines vary: NYT 1980+, AJC 1989+
• You can replicate your search later and get reliable results.
– Store a search to run whenever you specify (Alerts).
• You can take Dialog to court!
Who Uses Dialog?
25,000 customers in 103 countries reaching more than 2 million
end users:
• Corporations
– Pharmaceutical Companies
– Professional Services/Consulting
– Other industries
• Law firms
• Government agencies
– US Patent & Trademark Office
– Dept. of Homeland Security
– Other agencies
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Dialog Customers Work In…
• Information Centers and Libraries, of course
AND
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Research & Development
Intellectual Property Management
Competitive Intelligence
Market Research
Mergers & Acquisitions
Engineering
Sales
Strategic Planning
Fundraising & Development
Why use Dialog?
• Don’t free web search engines such as Google have everything?
• And isn’t it all free?
• Neither is true.
• Knowing when to use free services and when to use commercial
(fee-based) is critical.
• Even if the information is available at no cost, how much does it
cost in the time required to find the information?
Why use Dialog?
Value-added features:
• Boolean logic, truncation, proximity operators
• Indexing and structure – fields can be searched in both basic and
additional indexes
• Data manipulation, extraction and analysis – SORT, RANK, MAP
• Cross-file searching
• Duplicate detection
• Customized output formatting: XML, HTML, PDF, WORD, EXCEL
• Documentation and training
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Bluesheet for each database
Additional search aids, thesauri in many databases
How do I? Series: www.thomsondialog.com/howdoi
Free training and practice
Information request:
Find drugs in a specific state of development for particular
company.
Example:
What drugs does Abbott have in phase III clinical trials?
Let’s start with the free web:
What happens if you search Google using the terms <abbott> and
<“phase iii”>?
Find Drugs in a Specific State of Development for a
Particular Company?
? B 128
File 128: PHARMAPROJECTS 1980-2007/Jul W4
(c) 2007 Informa UK Ltd
Set Items Description
---
-----
-----------
? S ABBOTT/CO
S1
590 ABBOTT/CO
? S PHASE()III/ST
S2
1921 PHASE()III/ST
? S S1 AND S2
S3
43 S1 AND S2
Find Drugs in a Specific State of Development for a
Particular Company?
TYPE s3/6/1-2
3/6/1
DIALOG(R)File 128: PHARMAPROJECTS
(c) 2007 Informa UK Ltd. All rights reserved.
0042964
Drug Name: everolimus eluting stent
Published: 20070803 Revised: 20070801
3/6/2
DIALOG(R)File 128: PHARMAPROJECTS
(c) 2007 Informa UK Ltd. All rights reserved.
0042874
** Image available **
Drug Name: fenofibrate
Published: 20070420 Revised: 20070419
Find Drugs in a Specific State of Development for a
Particular Company?
? TYPE s3/19/2
3/19/2
DIALOG(R)File 128: PHARMAPROJECTS
(c) 2007 Informa UK Ltd. All rights reserved.
0042874
Drug Name:
** Image available **
fenofibrate
World Status: Phase III Clinical Trial
Pharma Status: Active
Synonyms:
ABT-335
ABT-335/SLV-348
SLV-348
Originator:
Abbott (USA) [Phase III Clinical Trial]
Licensee:
Solvay (Belgium) [Phase III Clinical Trial]
Latest Upd:
Updated On By Latest Change
20070417
SG Collaboration with Solvay as ABT-335/SLV-348 reported
Find Drugs in a Specific State of Development for a
Particular Company?
ACTIVITY DATA
Therapy:
Code
Description
F9Z9
Formulation, other
C10
Hypolipaemic/Antiatherosclerosis
Rte of Admin: Code
A-PO
Description
Alimentary, po
Pharmacology: Code -- Description
LPCF-AG -- Lipase clearing factor stimulant
Therapy Pharmacology Linking:
Code
Code1
Code2
Code3
Status
F9Z9
NA
Phase III Clinical Trial
C10
LPCF-AG
Phase III Clinical Trial
Indication:
Description --
Status
Hyperlipidaemia, general -- Phase III Clinical Trial
[sections of record deleted]
Pharmaceutical and Health Devices Applications
• Find drugs in a specific stage of development for a particular
company
• Find reported adverse effects of a drug
• Find a drug in a specific phase of development anywhere in the
world
• Find clinical trials for a specific drug for a specific indication
• Find interactions for a particular drug
• Find top ten drugs by sales in a given year
• Find drug or device recall notices issued by a particular company
Intellectual Property Applications
• Find a complete patent family
• Find the legal status of patents in a particular country
• Locate all patents for a specific company
• Set up an automatic patent watch
• Find technology a company has recently licensed
• Find prior art on patents for a specific technology
• Find a Japanese patent
• Order patents
Dialog
Choice of Interfaces
• DialogLink
– Command mode software for power searchers
• DialogClassic Web – new version Feb. 2007
– Command mode
• DialogWeb
– Command or guided mode
• DialogSelect
• Dialog1
• DialogPRO
– for small businesses
• Dialog Portals
• Dialog Open Access
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Interfaces for Different Skill Levels
Power
Precision
Ease of Use
Flexibility
__________________________________________________
Dialog1
DialogSelect
DialogWeb
(guided)
DialogClassic
DialogLink
Commands?
Command language gives you complete control over your search.
But…
What about end users who don’t want to learn commands. Can
they still use Dialog?
Yes!
(And they’re still using commands, they just don’t know it!)
SPY REPORT
Database List: 128
Current:
Search Command:
s (abbott)/co;
s S1 and phase()iii/st;
SORT /ALL/pd,d
Maximum for RD/Sort: 5000
Title List Format: 6
Full Record Format: 9
SPY REPORT
Database List: 128
BEGIN 128
Current:
NOT USED IN THIS SEARCH
Search Command:
s (abbott)/co;
S1
s S1 and phase()iii/st;
S2
SORT /ALL/pd,d
SORT RESULTS BY DATE
Maximum for RD/Sort: 5000
NOTE TO SYSTEM
Title List Format: 6
DISPLAYS TITLES
Full Record Format: 9
DISPLAYS FULL RECORD
ST=STATUS FIELD
How to Create a Spy Report
• Perform search in Dialog1, DialogSelect, or DialogPRO
• View address bar (View/Toolbars/Address)
• Put cursor at end of address bar, after the word SEARCH
• Type <&spy> and hit enter
• A new window will open with the spy report
 Use the spy report to analyze search strategy
DataStar
• Strengths in pharmaceutical and biomedical information
• European news and business information
• 350+ databases
• Unique content
• DataStarWeb – easy and advanced search
• WebCharts
• Database Finder, Datasheets
• Index word lists
• Alerts
• PrivateStar
Additional Resources for Learning Dialog
• Additional materials at www.dialog.com
– PDF versions of all training materials
– How Do I? - series of help screens
www.thomsondialog.com/howdoi
– Search aids: SmartTools, database-specific guides, Quick
Reference Cards, command comparison charts
• ONTAP databases
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Free unlimited use of subsets of selected databases
Data drawn from the actual databases
All Dialog commands and features are active
Great for practice searching and getting comfortable
Available for DialogClassic, DialogWeb, and DialogSelect
Additional resources to learn Dialog … more
• Web-based training courses
– 60 to 90 minutes in length, with a live instructor
– Basic skills and specialized topics:
• finding patent owners
• creating reports in Excel or Word
• comparing content of specific databases, i.e., Medline vs
Biosis vs Embase.
– All courses are free and do not require that you be a customer,
although you will be asked to register.
• Online tutorials
• Search assistance for customers (not students!)
Stay up-to-date with Dialog
• Subscribe to enewsletters
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Replaced Chronolog, published in print 1981-2005
File 410 has fulltext archive of Chronologs and enewsletters
Sign up at http://www.dialog.com/contacts/mailinglists/
Archives available at http://support.dialog.com/enewsletters/
General and subject specific newsletters
• GEP Newsletter
– For instructors and students
Enterprise Alert Manager: Context
• Resources are being redistributed from traditional information
centers to tools to directly support knowledge workers.
• Knowledge workers are increasingly using “non-traditional”
information tools (mobile devices, social networking services, blogs,
Wikipedia, etc.) to support decision making.
• IT staffs are adopting maturing technologies (Web Based APIs, XML,
RSS, and Federated Search Tools) to provide work flow solutions
across the entire enterprise.
• The creation of information continues to expand and organizations
who effectively manage this flow create competitive advantage.
Organizations need generic workflow solutions to support the
constantly evolving needs of knowledge workers.
Enterprise Alert Manager
Description
• A federated alerts and collaboration solution that enables the distribution and
access to internal and external content feeds across the enterprise
• Provides end user access to content feeds via RSS through a variety of delivery
mechanisms
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Email: Outlook, POP3, etc.
Web Browsers: Internet Explorer, Firefox, etc.
Mobile devices: Blackberry, Treo, Smartphones, etc.
Portals: Web Sphere, SharePoint, Plumtree, etc.
• Easily enables editorial review of feeds in order to create custom feeds
• Includes robust administration and collaboration tools based on corporate
directories (Active Directory, LDAP, etc.)
Enterprise Alert Manager
Mobile
Email
RSS
Enterprise
Alert
Manager
Portal
Non-Thomson Content
Intranet
Enterprise Alert Manager
Web Edition
The Enterprise Alerts
Manager allows for easy
review, annotation, and
sharing of content from
multiple sources.
Enterprise Alert Manager
MS Outlook Edition
Feeds can be integrated directly
in to MS Outlook.
Enterprise Alert Manager
Mobile Edition
Enterprise Alert Manager also
manages the delivery of
content to mobile devices.
Questions or comments?
[email protected]
http://gep.dialog.com