Transcript Results of Vote

Psoriatic Arthritis Workshop
OMERACT 7
Steering Committee
Dafna Gladman, Philip Mease, Gerald
Krueger, Désirée van der Heijde, Christian
Antoni, Philip Helliwell, Arthur Kavanaugh,
Peter Nash, Christopher Ritchlin, Vibeke
Strand, William Taylor
PsA Workshop
OMERACT 7
Objectives
 Identify
domains to be included in
clinical trials of PsA
 Develop a core set of domains
 Identify instruments to be used for
the domains.
 Develop a research agenda.
PsA Workshop
OMERACT 7
 Review
of assessment tools in PsA.
 Delphi exercise through
CASPAR/GRAPPA.
 Nominal group process through
GRAPPA.
 OMERACT 7
PsA Workshop
OMERACT 7
 Review
of process.
 Review of domains identified in
previous iterations.
 Review of instruments used in
clinical trials in PsA and psoriasis.
 Review of radiographic methods
used in PsA.
 Break out groups.
Results of Delphi Exercise
DMARD
Active Joint Count
Work disability
Pain
Work limitation
Patient global
Performance
X-ray damage
Tendonitis
Physical function
Cervical mobility
Acute Phase Reactant
Thoracic mobility
Quality of Life
MRI/US
Physician global
Sacroiliac signs
Skin disease
Fatigue
Damaged Joint Count
Extra-skeletal
Enthesitis
Sleep
Dactylitis
Utility indices
Morning stiffness
Lumbar mobility
Domain
Rank
Joint activity
1
Patient global
2
Pain
3
Physical function
4
Structural Damage
5
Skin disease
6
QOL
7
Enthesitis
8
Physician global
9
Acute phse reactants
10
Dactylitis
11
Axial involvement
12
Morning stiffness
13
Damaged joint count
14
PsA Workshop
OMERACT 7
 Review
of results from breakout
groups.
 Review of discussion from breakout
groups.
 Analysis of instruments used in two
drug trials in PsA.
 Voting on domains to be included in
clinical trials in PsA.
Results of vote on
Domains in PsA
PsA Workshop
Domains in PsA
Item
Joint activity
Patient Global
all 3 components
Pain assessment
Physical function
Skin disease
Quality of Life
Structural damage
Acute Phase Reactant
Axial involvement
Participation
Enthesitis
Score
99%
96%
76%
94%
91%
86%
78%
66%
64%
61%
61%
60%
PsA Workshop
Domains in PsA
Item
Fatigue
Dactylitis
Physician Global
Tissue histology
MRI
Morning Stiffness
Damage joint count
Score
48%
48%
41%
38%
34%
25%
20%
PsA Workshop
Research Agenda
 Identify
optimal joint count.
 Develop instrument for patient global to
incorporate skin and joint question.
 Identify optimal Skin assessment.
 Develop tools to define structural damage.
 Develop instruments for Axial assessment.
 Develop a tool for the assessment of
participation.
 Develop instruments for the assessment of
Enthesitis.
PsA Workshop
Research Agenda
 Develop
tools for the assessment
Dactylitis.
 Imaging modalities to assess
inflammation and damage.
 Develop Composite responder indices.
 Differential tissue response to therapies.
 Study methods to evaluate Fatigue in PsA.