Transcript Slide 1

ABSTRACT
The Effect of Drug-polymer Ratio on Physical Characteristics and In Vitro
Release of Alginate Microparticles of Teofilin
A research has been conducted to study the effect of drug-polymer ratio on
physical characteristic and in vitro release of alginate microparticles of teofilin. The
microparticle was prepared by orifice-ionic gelation methods with alginate
concentration 0,25; 0,5; 0,75 and 1. The obtain microparticle was observed for it
morphology, particle size, drug content and drug release. From the result it was
known that high concentration of sodium alginate resulted in smaller particle and
spherical shape. With increasing alginate concentrations the drug content became
lower and the drug release were less retarded.
Keyword: Sodium Alginate, Microparticles.