Transcript Targeting systems: new strategy for computational biology in

Targeting Systems: New Strategy
for Computational Biology in
Traditional Chinese Medicine
Yun Wang
Research Center for TCM Information Engineering
Beijing University of Chinese Medicine
[email protected]
Outline
• Background
• Systems: the way for TCM to realize the clinical effects
• Targeting systems
• A Proposed Platform for System-targeting TCM research
• A Simple Example
Background
• Purpose 1: Explain the functional mechanism of TCM
• Purpose 2: Provide lead compounds for structure
optimization
• Focus on: discovery of active components from TCM
Unfortunately:
• 1. weak effect of the components
• 2. activity dispersion during component separation
• 3. no better than “western medicine”, no better than TCM
• 4. seldom successful stories.
Systems: the way for TCM to
realize the clinical effects
• Fact1: Weak effect of components
• Fact2: Validated effect of TCM by clinical practice
• Inference: Interaction among components
Direct Interaction
(seldom)
Indirect Interaction
(often)
TCM function
• Systems are the targets of TCM function
TCM related
Biological system
Targeting systems: interpreting
the mechanism of TCM function
Direct Interaction
(seldom)
Indirect Interaction
(often)
Mechanism of TCM function
TCM related
Biological system
Targeting systems: bridging
biology and TCM theory
Direct Interaction
(seldom)
Indirect Interaction
(often)
TCM function
TCM theory
TCM related
Biological system
Targeting systems: providing new cues
for the treatment of complex disease
Direct Interaction
(seldom)
Indirect Interaction
(often)
TCM related
Biological system
TCM function
TCM theory
Validated clinical prescription
Targeting systems: providing new
resource for drug development
• Impact based molecular target selection
• “Remote” interruption of systems
• Complex drugs
Direct Interaction
(seldom)
Indirect Interaction
(often)
TCM related
Biological system
TCM function
TCM theory
Validated clinical prescription
A Proposed Platform for
System-targeting TCM research
TCM
pathway
Database
Active
compnts
mol
targets
bio
systems
Biological Systems related with TCM
Prescriptions that Promoting Blood
Circulation and Removing Blood Stasis
Map00100:
biosynthesis of steroids
Map00010:
glycolysis
/gluconeogenesis
Map00230:
purine metablism
Map00590:prostaglandin and leukotriene metabolism
Map00531: glycosaminoglycan degradation
Gaëlle Hardy, et. al.
Urinary leukotriene E4 excretion is increased in type 1 diabetic patients
A quantification by liquid chromatography–tandem mass spectrometry.
Prostaglandins Other Lipid Mediat. 2005. 78(1-4):291-299
220 paper’s title in CNKI
contaning:
promoting blood circulation
and removing blood stasis
+ diabetes
Thanks for Your Attention!