Transcript MedicineDrugs-MindAlteringDrugs7PPT

Mind-Altering Drugs
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Mind-Altering Drugs
Mind-altering drugs or hallucinogens as they are often
called affect the brain in such a way as to alter
perception of reality
Four different kinds of hallucinogenic drugs include
• LSD (lysergic acid diethylamide)
• Psilocybin and Psilocin
• Mescaline
• Cannabis (Marijuana & its active ingredient THC)
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Indole Ring Structure
The indole ring (or a
modification of it) is the
basic structure present in
almost all hallucinogens
including:
• LSD
• Psilocybin
• Psilocin
• Mescaline (Lacks the
complete ring.)
The indole structure
Mescaline – a partial indole
structure
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A Neuron Synapse
Neurotransmitter
chemicals such as
serotonin transmit
electrical impulses
Hallucinogenic
drugs affect the
transmission of
neural impulses
particularly in the
brain.
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Discovery of LSD
 Lysergic Acid Diethylamide (LSD)
was discovered in 1938 by a Swiss
scientist named Albert Hoffman.
 Hoffman tested some on himself,
not knowing the limits of a safe
dosage.
 He believed that the mind-altering
properties of LSD could be used for
medicinal purposes in the treatment
of psychological disorders.
 This research was discontinued
when it was discovered that LSD
lead to a very high incidence of
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LSD (Lysergic Acid Diethylamide)
 The discovery resulted from an
investigation of partially synthetic
amides of Lysergic acid.
 LSD does not occur naturally but
is derived from ergot, a fungus
that grows on wheat
 LSD was synthesized with the
intention of obtaining an analeptic
 Methergine was developed as a
result of LSD research. It is used
to stop hemorrhages.
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LSD (Lysergic Acid Diethylamide)
Note the similarities of the LSD structure to the
neurotransmitters: serotonin and L-Dopamine.
Each structure has an indole ring.
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LSD (Lysergic Acid Diethylamide)
LSD is believed to disrupt the way
that serotonin is used by the brain
Small doses, as little as 0.028 mg
will produce a noticeable effect.
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LSD (Lysergic Acid Diethylamide)
LSD is a large relatively nonpolar molecule.
It is membrane soluble and able
to enter the brain easily.
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Immediate Effects of LSD
 Very unpredictable.
 The immediate effects occur in
about 20 minutes and usually
last about 12 hours.
 Symptoms include restlessness,
dizziness, and alterations in
vision and audio perceptions
and hallucinations.
 Changes in body temperature
and heart rate
 Time becomes meaningless
 Feeling is often described as
flying.
 In some cases despair and
suicidal thoughts.
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Longer Term Effects of LSD
 Long-term mental health
problems after using LSD are
common.
 Significant potential for
“flashbacks” or latent
psychosis.
 Users may re-experience early
memories, pre-birth memories,
or flashbacks.
 Bad trips can be triggered
 Depression leading to suicide
is a long-term effect of using
LSD, and addiction.
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Longer Term Effects of LSD
•
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Link to major birth
defects when taken
during pregnancy
Brain deterioration
Flashbacks
Developing
tolerance leads to
high risk of
overdose.
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Mescaline
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MESCALINE (Peyote)
Mescaline is found in a small,
spineless cactus (known
botanically as Lophophora
williams ii) which grows in the
deserts of Mexico and the
American Southwest.
When the crown is sliced off and
dried, it forms a hard, brownish
disc known as a "button," which
is chewed for its hallucinogenic
properties.
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MESCALINE (Peyote)
 Mescaline is of the oldest
hallucinogens known
 Peyote buttons were chewed for
religious purposes in Mexico centuries
before the Conquistadors even knew
Mexico existed.
 Early tales of peyote rituals among
the Aztec and Toltec Indians date
ceremonial use back some 3,000
years.
 1560 Spanish explorers described the
effects on Mexican Indians as having
“terrible visions that lasted for 2-3
days”
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MESCALINE (Peyote)
The Spaniards quickly outlawed "peyotism,"
which they linked with cannibalism and
witchcraft, and enacted the first set of anti-drug
laws in the Western Hemisphere, all aimed at
wiping out Indian use of the plant.
During the American Civil War, peyote use
began spreading north from Mexico on a large
scale.
11 states have enacted laws to ban religious
use of peyote. Federal courts have affirmed
the right to sacramental use by Native
American religious use
A 1990 ruling by the U.S. Supreme Court,
affirmed the right of states to control ritual
peyote use
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MESCALINE (Peyote)
Peyote was also believed to be a
god-powerful medicine, capable of
giving sight to the blind and
healing incurable diseases.
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MESCALINE (Peyote)
The chemical
structure of
mescaline
contains three
ether groups and a
partial indole ring
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MESCALINE (Peyote)
 Peyote contains more than fifty
psychoactive ingredients
 The most powerful of which is
mescaline (3,4,5trimethoxyphenethylamine)
The hallucinogenic
effects of the mescaline
related compounds is
believed to be related
to the similarities of
their structures to
amphetamine.
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Effects of MESCALINE
(Peyote)
 Mescaline triggers increased
heart rate, body temperature,
and blood pressure and dilation
of the pupils.
 Normal coordination and
reflexes are reduced, and the
skin may feel dry and itchy.
 Peak effects hit 2-3 hours after
ingestion, and run their course
in 6-12 hours.
 Not as potent as LSD
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Effects of MESCALINE (Peyote)
Other effects can include :
 Rapid changes in mood
 Feelings of empathy and
kinship
 Distortions in perception
 Exasperates conditions of
anxiety and depression
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Psilocybin and Psilocin
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PSILOCYBIN
 Certain types of naturally
occurring mushrooms contain
hallucinogenic chemicals known
as psilocybin and psilocin.
 Psilocybin and Psilocin are
found in the liberty cap
mushroom (Psilocybe
semilanceata (Magic Mushroom)
 Dried mushrooms contain about
0.4 % psilocybin and trace
amounts of psilocin.
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PSILOCYBIN & PSILOCIN
 Psilocybin and psilocin belong to
the tryptamine family and their
effect is similar to the natural
neurotransmitter serotonin,
 Psilocybin and psilocin are both
alkaloids which means they are
nitrogenous substances that
appear in nature. .
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Structure of PSILOCYBIN
The structure of
Psilocybin has
an indole
structure shown
in the diagram
at the right.
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Structure of PSILOCIN
The structure of
Psilocin has an
indole structure
shown in the diagram
at the right.
The hydroxy
phosphate structure
is replaced with a
hydroxyl group
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Effects of Psilocybin and
Psilocin
 Within 30 minutes of taking small
amounts (i.e. 1-2 grams) of
mushroom, there is nausea, sweating,
feeling hot and shaky, heart racing,
lightheadedness, or anxiety.
 A relaxed feeling and a sharpening of
senses sometimes follow
 With larger amounts (2-14 grams)
they may experience time distortion,
euphoria, seeing brilliant colors,
flashing lights and even shapes and
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images.
Long Term Effects of
Psilocybin and Psilocin
 Long term effects unknown
 Danger of mushroom poisoning by
inability to distinguish from
poisonous varieties
 Poisoning occurs when there is
excessive vomiting, diarrhea,
headaches, chest pain, pounding
and racing heart, fear, anxiety,
paranoia, and seizures.
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MARIJUANA (cannabis)
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MARIJUANA (cannabis)
Marijuana is a drug made from the
stems, flowering tops, leaves and
seeds of the hemp plant (cannabis
sativa).
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MARIJUANA (cannabis)
 The active ingredient in
Marijuana is a compound
called Tetrahydrocannabinol
(THC).
 Structurally THC contains
multiple carbon rings, with
several methyl groups
attached, and –OH group on
a benzene ring, as well as a
five carbon chain.
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MARIJUANA (cannabis)
The concentration of THC is the determines the
potency and effects of the drug.
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Other Cannabinoids
Other hallucinogenic compounds found in
marijuana
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MARIJUANA (cannabis)
 Generally marijuana has a THC
content of 1-3% with specialized
breeding making contents of
slightly higher possible.
 Hashish, made from the resin of the
hemp plant is much more potent
with concentrations between 10 to
15%.
 The THC content of any of the
products of the hemp plant
depends greatly on the
environment in which the plant is
grown.
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Effects of Cannabis/THC
 Feelings of relaxation
 Has been used to relieve pain
in some terminally ill patients
 Enhanced visual and auditory
perceptions
 Confusion and emotional
distress
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Long term effects
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Lethargy and apathy
Lowering of fertility
Decreased mental capacity
Gateway drug
Potential for abuse
Illegal activities associated
with Marijuana trade
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Long Term Use
1. Addictive properties are not
entirely known.
2. Some experts believe that
marijuana is less addictive than
alcohol or nicotine, both of which
are legal.
3. Risk of long term brain damage is
not entirely known. Indication that
it leads to early onset of
schizophrenia
4. Use by underage people risks
potential brain damage
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Impact of THC on the Brain
1. It is known that THC affects and
influences the activity of cells at
specific sites called cannabinoid
receptors on nerve cells in the brain.
2. Some areas of the brain have many
cannabinoid receptors; others have
few or none.
3. Many cannabinoid receptors are
found in the parts of the brain that
influence pleasure, memory, thought,
concentration, sensory and time
perception, and coordinated
movement.
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Impact of THC on the Brain
1. Recent studies in
Australia indicate that
prolonged use of
Marijuana leads to
reduction of brain
capacity
2. Brain scans showed
the hippocampus and
amygdala were smaller
in men who were
heavy marijuana users
compared to nonusers
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Legalization of Marijuana
Arguments in Favor
1. Marijuana is already available
medically to many terminally ill
patients as well as for many other
conditions
2. Legalization would allow police to
focus there efforts on more
violent crime
3. Taxes on marijuana would
possibly generate large amounts
of revenue
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Legalization of Marijuana
Arguments Against
1.
2.
3.
4.
5.
Increased costs to society: especially
from cancer and heart disease from
smoking.
Increased danger from people driving
under the influence.
Marijuana abuse would increase.
Marijuana’s status as a gateway drug
would lead to increased addiction to
more dangerous drugs such as cocaine,
methamphetamines, and heroin.
Long term impact of substantial
marijuana use may lead to more serious
mental disorders.
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“Can a thorough understanding of the use and
chemical composition of these drugs lead to the
discovery of new pharmaceutical tools for
psychiatric treatment or experimentation?”
“Hallucinogens must be classed as a toxic.
They induce unmistakable intoxications. In a
broad sense they are narcotics.”
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“In all things there is a poison, and
there is nothing without a poison. It
depends only upon the dose whether
something is poisonous or not.”
-- Paracelsus -16th Century
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