Transcript IDIS presentation

Iowa Drug Information Service
(IDIS)
Iowa Drug Information Service (IDIS)
 Publisher
 University of Iowa College of Pharmacy
Division of Drug Information
 Years Covered
 1966 to Present
 Scope
 Only includes articles about drugs in human
therapy
Iowa Drug Information Service (IDIS)
 Immediate access* to full-text articles from
200+ English-language biomedical journals
(includes several international journals)
*
= from 1995 to Present available as PDF
document
 Prior to 1995, full-text articles are on microfiche
CD Search Screen
Internet Search Screen
Controlled Vocabulary
 Similar to MeSH terms and Limits
 Drug
 Disease
 Descriptor
Drug
 Valid drug name is the United States Adopted Name
(USAN).
 Valid drug number is a 7- or 8-digit modified American
Hospital Formulary Service (AHFS) number.
 Therapeutic categories are arranged in hierarchal order.
 Examples:

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24000000- Cardiovascular agents
24040000 – Cardiac agents
24040100 – Cardiac glycosides
24040103 – Digitoxin
Disease
 Valid disease names and code numbers are from the International
Classification of Diseases, 9th Revision, Clinical Modification (ICD-9CM) (a commonly used system of classifying diseases).
 Example:
 If you search for “varicose vein” in the Thesaurus, using the Look Up
button next to the Disease field, or using the Disease Hierarchy, you will
find several types of varicose veins and their associated codes:


• VARICOSE VEIN, LW EXTREMITY 454.
• VARICOSE VEIN NEC 456.
• VARICOSE VEIN, ESOPHAGEAL 456.0
• VARICOSE VEIN, SCROTAL 456.4
• VARICOSE VEIN, VULVAL 456.6
The periods in the codes subdivide the disease terms.
The term NEC means “not elsewhere classified”
Descriptor
 There are more than 150 valid descriptor
terms (with codes) which further limit
information. Click the Look Up button next to
the Descriptor field to see the entire list.
 Get to know the descriptors.
 Use the Descriptor Definitions link to search for
the definition if you don’t understand what it
means.
 Examples:
 Study Randomized Adult 135
 Side Ef Musculoskeletal 77
 Adm Parent Intraarticular 114
Descriptor Categories
 Article type (and population – adult, pediatric,
geriatric)

Case report/series, reports, reviews, studies (casecontrolled, cohort, randomized), government document,
design/analysis (cross-over, meta-analysis, n-of-one
trial, practice guideline, systematic review), and
continuing education.
 Outcome
 Clinical results, economic outcomes, general outcomes,
quality of life.
Descriptor Categories (continued)
 Pharmaceutic
 Drug analysis, drug manufacture, drug properties,
pharmaceutic incompatibilities, pharmaceutics.
 Therapeutic
 Route of administration, clinical incompatibilities
(contraindication, drug interaction, lab interaction,
dietary interaction), clinical issues (dosage, mechanism
of action, modification of effect, pharmacodynamics),
drug use, side effects/adverse reactions, toxicology.
Thesaurus
 Cross references all synonyms, trade names, or concepts
to their valid drug/disease/descriptor terms/codes (valid
terms appear in uppercase followed by their code
numbers).
 Note that in the Thesaurus:
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

(DR) = drug term
(DI) = disease term
(DE) = descriptor term
 Examples:
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thyroid dr – locates the word thyroid in the Drug field
thyroid di – locates the word thyroid in the Disease field
thyroid de – locates the word thyroid in the Descriptor field
Other Ways to Search
 Word(s) in the title and/or the abstract
 Author(s) (you can use the Look Up button next to
this field)

Example (enclose in quotation marks: last name,
space, first initial, space, second initial):
• “Smith J P” (you know the author’s last, first, and middle [if
there is one] initials; IDIS even indexes the third initial if one is
provided in the article)
• “Smith J” (will give you all the Smiths whose first name begins
with “J”)
• “Smith” (will give you all the Smiths)
• “Smith*” (will give you all the authors with Smith as the first 5
letters of their last names – Smith, Smithard, Smithee,
Smithells, etc.)
Other Ways to Search (continued)
 Journal (must use the correct IDIS journal
abbreviation; use the Look Up button next to this
field to locate the correct abbreviation)
 Volume, issue, starting page number (if known)
 Year
 Default is all years through current year.
 For 1 year, enter the same year into both the starting
and ending year fields.
 For a range of years, enter the starting year and ending
year.
Other Ways to Search (continued)
 Article number (if known)
 Sequence number (if known) – don’t worry about this too
much. Each article is assigned 1 unique article number,
but sometimes it will have 2 sequence numbers if all our
indexing terms won’t fit in one record or if the article
contains more than one primary concept.
 All fields – Caution: use of this field will result in MANY
irrelevant citations (cross references of cross references of
cross references, etc., in the Thesaurus are checked).
This field is good to search for unique terms,
abbreviations, or exact phrases that do not have a valid
drug, disease, or descriptor term.
Example
 Search for case reports in which
rasburicase was used to treat acute
lymphoblastic leukemia in children.
Example: Using the Lookup Buttons
 Drug
 Valid term/number: "RASBURICASE
2000004"
 Disease
 Valid term/number: "LEUKEMIA, LYMPHOID,
ACUTE 204.0"
 Descriptor
 Valid term/number: "CASE REPORT
PEDIATRIC 1"
Example: Using the Thesaurus
 rasburicase dr
• Locates rasburicase in the Drug field (RASBURICASE
2000004)
 acute lymphoblastic leukemia di
• Locates acute lymphoblastic leukemia in the Disease field
(LEUKEMIA, LYMPHOID, ACUTE 204.0)
 case report de
• Locates case report in the Descriptor field – there are 3 types;
select the one that applies to children (CASE REPORT
PEDIATRIC 1)
• In this example, you will have to use “common sense” or the
thesaurus of a dictionary to determine that pediatric = children.
Use the Descriptor Definitions link to find that a pediatric
patient is a newborn to 12 years of age.
Example: Results
 This search yields 2 results (articles 559551 and 505702)
 To see all the terms that were used to index the article,
change the “Output/Display Format” to Full Results and
click Adjust. This is similar to looking at the full citation in
PubMed to get an idea of other terms you might want to
search for.

Note about Full Results: You can work backwards if you find a
relevant citation in another database; locate the article in IDIS
using the other fields or general terms, look at the “Full Results” of
what you get to see the valid terms, plug them in, and redo the
search to locate more articles on the subject.
 Click on the article number to read the article.
IDIS Search Tips
General Search Tips
 The key to successful searching in the IDIS
database is being able to use and apply the
Drug, Disease, and Descriptor fields.
 Before executing the search, make sure
your operators make sense. If not, correct
them. There are different defaults (“and”
vs. “or”) in different fields.
Truncating Words
 Use the asterisk (*) to truncate words. This
will allow you to find the term if it isn’t
indexed exactly the way you think it is. For
example, “kidney ston*” would find kidney
stone, kidney stones, kidney stonage,
kidney stoning (all of these terms aren’t in
IDIS or even real terms, but this is just to
give you an example). Think about
appropriate places to truncate terms.
Sources of Help Within IDIS
 Help link
 Links on the left side of the screen
 Information button (i) next to each field
Thesaurus
 The Thesaurus is the official “dictionary” of
controlled vocabulary terms.
 Don’t forget to add DR, DI, or DE,
depending on what you are looking for so
that you won’t have to scroll through
irrelevant terms.
Exploding Drug Classes
 Explode drug classes by locating the class in the
Thesaurus, and truncating the drug code at the
appropriate place.
 For example, if you search 24040100 (cardiac glycosides
– a class of drugs), your search will only retrieve articles
that talk about that class in general. It will not locate
articles about the individual drugs in the class. If you
wanted information about all cardiac glycosides, you
should search 240401*. This will pick up 24040101
(deslanoside), 24040102 (digitalis), 24040103 (digoxin),
etc.
Population Tags
 IDIS uses “population tags” in the Disease field:
 Neonate, pediatric, puberty and adolescence, and
geriatric are all “population tags” that can be used in
the Disease field (search the Thesaurus for them).
 If you are looking for any type of article related to one of
these age groups, use the appropriate population tag in
the Disease field (instead of searching for the age
group using an article type in the Descriptor field).
Article Classifications Without Descriptors
 Search Author field for:
 “Editorial” - editorial
 “Letter to ed” – letter to the editor
 Search Disease field for:
 “Corrigendum” – erratum, addendum,
retraction (type will be indicated in Title
field)
Specific Types of Questions:
Side/Effect Adverse Reaction Caused by a Drug
 Locate articles about a side effect/adverse
reaction that a drug causes:
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Drug:
• Enter the drug that is causing the side effect/adverse reaction.
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Disease:
• In general, you won’t need a disease term because the drug
will likely cause the side effect/adverse reaction in all diseases,
so disease isn’t important in these cases (unless the question
specifies a specific disease).

Descriptor:
• Use the appropriate side effect/adverse effect descriptor.
Searching the Thesaurus for “drug induced” and the side
effect/adverse reaction that you are looking for will usually
provide the correct descriptor.
Specific Types of Questions:
Drug Used to Treat Side Effect/Adverse Reaction
 Locate articles about a drug that is used to treat
a side effect/adverse reaction of a drug:
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Drug:
• Enter the drug that is being used to treat the side effect, NOT
the drug that caused it .
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Disease:
• Enter the term “ TX/AE-Drug/Chemical E999.” plus the disease
term/code for the disease that the drug caused.

Descriptor:
• Generally will not use a side effect/adverse reaction descriptor
unless it has to do with the drug that is in the Drug field. Other
types of descriptors may apply if the question calls for it.
Specific Types of Questions:
Drug Interactions
 Locate articles about two or more drugs
that interact:
 Drug:
• Enter all drugs that interact (use AND operator).
 Disease:
• Generally won’t use
 Descriptor:
• “Drug interaction 50” and “Drug combination 16”
– Alternatively, you can enter:
• 50 and 16
Specific Types of Questions:
Drug Used to Prevent a Disease
 Find articles about a drug(s) that are used
to prevent a disease:
 Drug:
• Enter the drug(s) that is/are being use to prevent the
disease.
 Disease:
• Enter the term “Prophylaxis NEC V07.” plus the
disease term/code that the drug is preventing.
 Descriptor:
• As indicated.
Specific Types of Questions:
Suicide/Overdose/Poisoning
 Find information about a drug that someone has
overdosed or been overdosed on, has tried to
commit suicide with, has been poisoned with, or
is showing signs of toxicity from:

Drug:
• Enter the drug(s) of interest.

Disease:
• Enter the term/code “Suicide/Overdose/Poisoning E950.”
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Descriptor:
• As indicated.