Transcript Sleep Aids

Sleep Aids
By Jobin S. Kalathil
Sleep Orders of Interest:
Insomnia: is characterized by the inability to fall
asleep and/or remain asleep for a reasonable
amount of time.
Restless legs syndrome (RLS): is characterized by
an irresistible urge to move legs while sleeping.
Bed wetting: is associated with the involuntary
passing of urine while asleep; after the age at which
bladder control would normally be anticipated.
General Principles of Treatment:
Treatments for sleep disorders can be grouped into
three general categories:
1) behavioral/ psychotherapeutic treatments
2) medications
3) other somatic treatments (like surgery)
Insomnia
The three types of insomnia are:
1) Transient insomnia
2) Acute Insomnia
3) Chronic Insomnia
Medications:
The most commonly used drugs are:
F Benzodiazepines
Commonly prescribed
benzodiazepines
include: temazepam,
diazepam, lorazepam,
flurazepam, nitrazepam
and midazolam
http://www.etfrc.com/benzos1.htm
Non-benzodiazepine
prescription drugs
QuickTimeª and a
TIFF (Uncompressed) decompressor
are needed to see this picture.
Ambien
Lunesta
 Selectively binds to the
melatonin receptors
instead of GABA
receptors.
Rozerem
Restless Leg Syndrome
 Requip
http://www.neurosci.pharm.utoledo.edu/M
BC3320/images/Ropinirole.gif
Bed wetting
 Two main types of drugs
prescribed:
 Tricyclic antidepressant
prescription drugs (e.g.
Amitriptyline, Imipramine or
Nortriptyline)
Bed wetting
 Desmopressin
Works Cited
 "Cognitive Behavior Therapy and Pharmacotherapy for Insomnia."
Archives of Internal Medicine 164. 16 Mar. 2007
<http://archinte.amaassn.org/cgi/content/abstract/164/17/1888>.
 Griffiths, Rr, M.w Johnson, and P.e Suess. "Ramelteon: a Novel
Hypnotic Lacking Abuse Liability and Sedative Adverse Effects."
 "Mechanism of Action." Requip. 13 Mar. 2007
<http://www.requip.com/pd/hcp/mechanism_of_action.html>
 Archives of General Psychiatry 63 (2006): 1149-1157. EBSCO. SMU.
12 Mar. 2007. National Institute of Health. Ambien. 12 Mar. 2007
<http://dailymed.nlm.nih.gov/dailymed/fdaDrugXsl.cfm?id=635&type=di
splay>.
 "New Drug Offers Relief From Chronic Insomnia." Cortlandt Forum 19
(2006): 22. EBSCO. SMU.
 "New Evidence That the Pharmacological Effects of
Benzodiazepine Receptor Ligands Can Be Associated with
Activities At Different BZ (?) Receptor Subtypes."
Psychopharmachology. PubMed.Gov. 12 Mar. 2007.
 Office of Communications and Public Liaison. National Institute
of Neurological Disorders and Stroke. Restless Legs Syndrome
Fact Sheet. 14 Feb. 2007. 12 Mar. 2007
<http://www.ninds.nih.gov/disorders/restless_legs/detail_restless
_legs.htm#84783237>.
 "PRAMIPEXOLE/ROPINIROLE." National Institute of
Neurological Disorders and Stroke. 11 Mar. 2007
<http://www.ninds.nih.gov/funding/research/parkinsonsweb/drug
_summaries/pramipexole.htm>.
 "Requip." GlaxoSmithKline. 11 Mar. 2007
<http://us.gsk.com/products/assets/us_requip.pdf>.
 "REQUIP." http://www.requip.com/. GlaxoSmithKline. 15 Mar.
2007 <http://us.gsk.com/products/assets/us_requip.pdf>.
 "Restless Legs Syndrome." Wikepedia. 14 Mar. 2007
<http://en.wikipedia.org/wiki/Restless_legs_syndrome>.
 "Rozerem." Wikipedia. 10 Mar. 2007
<http://en.wikipedia.org/wiki/Rozerem>. "Sleep Disorders."
Wikipedia. 9 Mar. 2007
<http://en.wikipedia.org/wiki/Sleep_disorder>.
Wake Up