Transcript General Mechanisms of Drug Action

Introduction to Clinical Pharmacy–
a key role for pharmacists.
Year 3 Peradeniya University SOP
Dr Ian Coombes,
Clinical senior Lecturer - School of Pharmacy + Medicine,
University of Queensland, and Senior Pharmacist,
Safe Medication Practice Unit, Brisbane, Australia
Mrs Judith Coombes
Conjoint Lecturer - School of Pharmacy, University of
Queensland and Senior Education Pharmacist, Princess
Alexandra Hospital, Brisbane, Australia.
Content
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Introduction to Us and You
What is clinical pharmacy and why do we need it
Medicine management and patient journeys
Adverse drug events – the problem
Product versus patient focused services
Perception of the profession
Drivers for change –its development elsewhere
Core practitioner skills, knowledge and attitudes,
Plan for the next 6 weeks
Background - Queensland
700 km W - E
1900km
N-S
1.8Million
km2
4 M people
in Qld
Brisbane
Queensland
Brisbane
Comparisons
Sri Lanka (7 degrees N of equator)
Australia (14 degrees S of equator)
66,000km2
7,600,000km2 (120x)
20 million people
20.3 million people (=)
8.5% >65 year
13.3% >65 yr (1.5 x)
3.7% GDP on healthcare
9.5% GDP on healthcare (2.5x)
$160M/ yr/ on free Health
$80 BN/ yr/ Health
$42 /person/year on health
$3,900/person/year on health
2 hospital beds/ 1000 people
3.6 hospital beds/ 1000 people
New 4 year pharmacy degree
4 year pharmacy degree
1000 hospital pharmacists,
14,000 pharmacists, 3000 hospital
Doctor order, pharmacist supply
Separation of supply from ordering
Judith Coombes
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University Queensland
Pre-registration (apprenticeship year) community
District hospital (Rockhampton) 700km N
UK hospitals 2 years, wards and dispensary
PAH renal specialist pharmacist
UK MSc (Clin Pharm) DI + research pharmacist
PAH, 700 bed teaching, Drug use evaluation
Conjoint Lecturer U of Qld + PAH education
Ian Coombes
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University of London – wanted be in advertising!
Pre-registration year - London Hospital
Junior training – London Hospital
Working holiday in Brisbane, 2 hospitals
Msc in Clin Pharm, ICU, renal, cardiac jobs - UK
Manage Clinical Services + cardiac + PAC – PAH
Safe Medication Practice Unit
PhD
State wide pharmacy + prescriber education
Perceptions of Pharmacists
How do others see us?
“They just count a few tablets”
“They just weigh and measure things”
“A bunch of shop-keepers”
“Tell me how and when to use the Medicine”
“Counter-prescribing”
“Not really health care practitioners – they’re
businessmen”
“Do you need a degree to be a pharmacist?”
Drivers for change
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Competence of health care practitioners
- Diploma to BSc to BPharm + Pre-registration +
registration
- Continuing Professional Development.
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Re-engineering of community medicine supply
- Provided by competent practitioners
- Recognition that dispensing is a technical function
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Informed general public – increased expectation
Realisation that ………………….
Medicines are Dangerous
Pharmaceutical Care
“ A practice in which a practitioner takes
responsibility for a patient’s drug related
needs and holds him or herself
accountable for meeting these needs.”
Linda Strand 1997
Effective drug
therapy
What does the
patient view as an
improved quality of
life?
Improve
quality of life
Will the patient take
the therapy?
Safe drug
therapy
Aims of
Pharmaceutical
Care
Economic drug
therapy
A case
• 44 year old lady with fever and green sputum
and cough – no known previous medical history
– Diagnosed with upper resp. tract infection
Pharmaceutical problems
• Prescribed:
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Co-Amoxiclav 1 tds
Doxycycline 100mg D
Prednisolone 40mg D
Theophylline 200mg bd
Omeprazole 20mg D
Metoclopramide 10mg tds
Salbutamol 2 puff inhale prn
Common organisms for URTI?
Need for atypical organism ?
History of asthma – risk vs benefit?
History asthma – risk vs benefit
Need for acid suppression?
Why is she nauseous ?
Benefit of brochodilation?
Does she know what to take?
Will she take it?
Why did you choose to do this
course?
What do you envisage doing when
you become a pharmacist?
2 minutes talk to your neighbour and
then feedback
Question?
• Think of someone in your family or a friend
that has had something go “wrong” with their
medicines?
– Caused an adverse or unwanted effect ?
– Had medicines stopped when should have
continued?
– Not worked?
– What happened ?
– Could it have been avoided ?
Medical/medication errors in the UK
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Adverse events occur in 10% of admissions
An estimated 850,000 adverse events a year
Adverse events cost approximately £2 billion/yr
The NHS pays £400 million clinical negligence
Medication errors accounts for around a quarter
of the incidents which threaten patient safety
The Chief Medical Officer
An Organisation with a Memory
Department of Health (2000)
High Profile Examples
• A patient with leukaemia received Intrathecal vincristine
instead of intravenously. Died beginning of February
2001. 14th such case over the last 16 years.
• Patient being operated for a AAA received bupivicaine
intravenously rather than epidurally. Patient died 3 days
later.
• A 3 year old girl, who had a convulsion post flu vaccine.
Attended hospital to get “checked out”. Received nitrous
oxide instead of oxygen in casualty
High Profile Cases (Cont.)
• Elderly lady prescribed Methotrexate in 1997 for her
rheumatoid arthritis. Dose increased to 17.5mg
WEEKLY over a 6 month period.
• Jan 2000 patient undergoes right TKR in hospital. MTX
given as one tablet a week (only 2.5mg).
• 6th April 2000 patient asks GP to reduce number of
tablets “as in hospital”.
• Prescription for MTX 10mg/daily written and
dispensed.
• 30th April patient dies.
Deaths from medicines in the UK
1999 - 2000 (ICD9 & 10 data)
A spoonful of sugar - Audit Commission (2001)
So drugs are safe ………………..
Photosensitivity from
Amiodarone
Severe extravasation of
amiodarone infusion
NSAID or COX-2 induced peptic ulcer
Goitre – Hypothyroidism
Secondary to Amiodarone
Bleeding due to
anticoagulation
Erythemal rash from penicillin – in patient with a previous
Known allergy/ adverse drug reaction
Necrotising fascititis – secondary to infection at site of IV injection
Acute Liver failure from Black Cohosh - herbal medicine
Human Error
(Mistakes, Slips, Lapses)
• Error is inevitable due to “our” limitations:
- limited memory capacity
- limited mental processing capacity
- negative effects of fatigue other stressors
• We all make errors all the time
• Generalised lack of awareness that errors occur
• Patients suffer adverse events much more often
than previously realised
• Errors often NOT immediately observed
The same error, even a minor
one, can have quite different
consequences in different
circumstances.
The System:
Only as safe as it’s designed to be!
“I assumed the brown glass
ampoule was frusemide”
(ICU RN after injecting 10mg
adrenaline)
The Accident Causation Model
(Adopted from Reason & Dean)
Latent
Conditions
Error
producing
conditions
Active
Failures
- Slips&lapses
- Mistakes
Accident
Defences
The Medicines Management Cycle
• What happens between a doctor seeing a
patient and them receiving or taking their
medicine ?
• 2 minutes discuss with neighbor
The Medicines Management Cycle
DOCTORS
Decision to
prescribe
Transfer
information
Monitor
response
Order entry
Review order
Patient
Supply medicine
Administer
Distribute
Nurses
Supply
information
Pharmacy
From Bates et al 1995
Sources of Error
• Prescribing error - selecting the wrong or
inappropriate drug/dose/formulation/duration etc
• Communicating those instructions
• Supply error - timely; wrong drug, dose, route;
expired medicines, labelling.
• Administration error - timing; wrong route; wrong
rate/technique.
• Lack of user education - actions to take.
Where do things go wrong with medicines?
Frequency
(literature) %
Frequency
Errors
(600 bed
Hospital)
Drug Related
5 – 20 % of unplanned 4 – 15 patients /
admissions
admissions
day
Prescribing
2.5 –10 % of orders
40 – 160 orders
errors
in error/ day
Dispensing
0.01 – 0.05 % of items 1-5 leave the
errors
pharmacy/ week
Administration 5- 15% of doses
40 – 100 doses/
errors
day
Discharge
5 –17% of items for
20 –70 items in
prescribing
discharge
error/ day
Comparability to Australian National
Health Priority Areas
In 2000-01, hospital admissions
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Angina: 88,500
Myocardial infarction: 37,500
Asthma: 49,000
Diabetes: 46,000
– Adverse Drug Events: 140,000
Reducing the risk of adverse events
• Always
– include a detailed drug history in the consultation
• Only
– use drug treatment when there is a clear indication
• Stop
– drugs that are no longer necessary
• Check
– dose and response, especially in the young, elderly
and those with renal, hepatic or cardiac disease
Pharmaceutical Care
“ A practice in which a practitioner takes
responsibility for a patient’s drug related
needs and holds him or herself
accountable for meeting these needs.”
Linda Strand 1997
Safe drug
therapy
Effective drug
therapy
Aims of
Pharmaceutical
Care
Improve
quality of life
Economic drug
therapy
Aims of Pharmaceutical Care
• Identify actual and potential drug related
problems,
• Resolve actual drug related problems,
• Prevent potential drug related problems.
Drug therapy assessment
Six types of problems which may result in
treatment
failure
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1. Inappropriate selection of medication
2. Inappropriate formulation of medication
3. Inappropriate administration of drug therapy
4. Inappropriate medication-taking behaviour
5. Inappropriate monitoring of drug therapy
6. Inappropriate response to drug therapy
Pharmaceutical care planning
Process of work
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collect relevant patient information
assess information
identify problems
state desired outcomes
prioritise problems
develop an action plan for each problem
was desired outcome achieved?
Pharmaceutical Care Activities (1)
• Patient Consultation - discuss expectations
and concerns,
• Pharmacist’s assessment - identify current
or potential drug therapy problems,
• Creation of a care plan - establish goals of
therapy, action to be taken and outcomes to
be monitored.
• Communication of that plan eg Dr, nurse
other pharmacist, patient, carer
Pharmaceutical Care Activities (2)
• Patient education and/or referral –
• provide individualised, current information
about drug therapy and how to use;
Demonstrate special techniques; refer to
doctor or other HCP.
• Patient monitoring and follow-up –
• are the goals being met.
Refocusing the profession because :1. Problems caused by drug use in society,
2. Business orientated approaches place the
product before the patient,
Pharmaceutical care is :• a patient-centred approach (not drug-centred),
• a process of managing drug-related problems,
• Where pharmacists take responsibility for
provision of drug therapy.
Clinical Pharmacy Role in Reducing Risks
Admission medication history
Formulary
Prescribing protocols
Allergy check
Prospective review
Administration instructions
Clinical pharmacy
Drug distribution system
Opportunity
For Error
What if we are not there!
Admission medication history
Formulary
Prescribing protocols
Allergy check
Prospective review
Administration instructions
Clinical pharmacy
Drug distribution
system
Opportunity
For Error
Adapted by P.Thornton from J. Reason, 9/01
Outcomes of Pharmaceutical Care(1)
• The patient receives effective drug
therapy - based on the evidence of current
medical literature (Evidence based Medicine).
• The patient receives safe therapy - based
on a knowledge of their individual clinical
circumstances.
Outcomes of Pharmaceutical Care(2)
• The patient receives the most economic
therapy - not compromising efficacy or
toxicity
• The patient receives drug therapy desired
to improve their quality of life.
Patient Assessment Questions
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Does the patient need this drug ?
Is this drug the most effective and safe ?
Is this dosage the most effective and safe ?
If side effects are unavoidable does the patient
need additional drug therapy for these side effects?
• Will drug administration impair safety or efficacy ?
• Are there any drug interactions ?
• Will the patient comply with prescribed regimen ?
To be a drug expert society needs
practitioners who ……..…
Key knowledge, skills and attributes
Knowledge base
• Chemistry,
• Pharmaceutics,
• Pharmacology,
• Therapeutics,
• Law, Ethics, Professional conduct.
Skills base
• Problem solvers,
• Make decisions,
• Good communication + Effective consultation process,
• Gather information,
• Calculate doses,
• Offer advice that’s timely and accurate (Pts, Dr’s and Nurses),
• Dispense medicines,
• Monitor and follow up
Key knowledge, skills and attributes
Attributes
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Takes responsibility for actions;
Punctual;
Caring nature;
Professional behaviour;
Open minded;
Positive attitude;
Treats patients equally;
Treats information confidentially;
Key Responsibilities
1. Act in the interest of patients and seek to provide the
best possible health care for the community.
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Treat all with courtesy, respect and confidentiality.
Respect patients’ rights to participate in decisions about their
care
Provide information which can be understood.
2. Must ensure that their knowledge, skills and
performance are of high quality, up to date, evidence
based and relevant.
3. Behave with integrity
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adhere to accepted standards of personal and professional
conduct
Summary
• Drugs are beneficial but can also cause harm.
• Society needs a gatekeeper who manages the
use of drugs.
• Pharmacists must adopt a patient focused
approach to identifying and resolving drug
related issues.
• The consultation process and effective
communication lies at the heart of achieving this.
Plan for next 6 weeks
• Topics:
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Abbreviations,
Evidence based medicine
Medication history taking, confirmation, reconciliation
Effective communication with other clinical staff
Therapeutic – c-vasc, respiratory, renal, neurology (pain) ,
gastro
• Teaching and learning methods:
– Didactic, set some tasks, feedback go through in tutorials
The End
Any Questions?