Transcript Title slide design, replace text

Effects of long-term plant sterol or stanol
ester consumption on lipid and lipoprotein
metabolism in subjects on statin treatment
de Jong et al. Br J Nutr 2008; 100:937-941.
23.08.2011 Copyright® Raisio
Background
Subjects on statins may not reach the cholesterol target
Plant stanol ester consumption has been shown to be
effective in statin using subjects:
• Statin drug and plant stanol ester have different
cholesterol lowering mechanisms:
• Statins inhibit cholesterol synthesis
• Plant stanols reduce the absorption of cholesterol in
intestine
The aim of the study was to confirm that the serum LDLcholesterol-lowering effect of plant stanol ester is
sustained also in statin using subjects.
de Jong et al. 2008
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Methods I
54 subjects on stable statin treatment
1. 5 week run-in with placebo margarine
2. randomization to 3 different treatment groups for
85 weeks
• placebo margarine (n=17)
• plant stanol ester margarine (2,5 g/d plant stanols) (n=19)
• plant sterol ester margarine (2,5 g/d plant sterols) (n=18)
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Methods II
Blood samples were collected
• in the beginning and in the end on run-in period
• duplicate samples in 5, 25, 45, 65 and 85 weeks into
the study
• analyses for lipids and apolipoproteins; plant stanols
and plant sterols and markers of cholesterol
metabolism
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Results I
Calculated daily plant stanol/sterol intake was 2.5 g
 Study subjects adhered well to the guidance given
regarding the use of the test products
No differences in the energy intake or the nutrient
composition of the diet at base-line or during the
study, no weight-change
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Results II
Plant stanol consumption lowered total cholesterol by 9.4 %
and LDL-C by 13.1 % compared to placebo (p=0.003 & 0.006)
Plant sterol consumption lowered total cholesterol by 5.1 %
and LDL-cholesterol by 8.7 % compared to placebo (p=0.092 &
0.080)
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Plant stanol ester effectively reduces LDL
cholesterol in combination with stable
statin treatment
THE CHOLESTEROL-LOWERING EFFECT IS LASTING ALSO IN STATIN USING SUBJECTS
Change (%) in LDL cholesterol
Run-in period
Week 45
Week 85
Plant sterol
ester (2.5 g/day
plant sterol)
Plant stanol
ester (2.5 g/day
plant stanol)
*
*
*p<0.05
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Conclusions
Consumption of plant stanol ester significantly
reduces serum total and LDL-cholesterol levels in
subjects on stable statin drug use
The cholesterol-lowering effect is lasting also in
statin using subjects.
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Thank You!
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