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Pharma is experience challenges 1,000,000,000 7,000,874 6587 423 8 1 US $ investment hours of work experiments researchers years drug We want to contribute Pharma R&D is adapting for the future • Dedicated Science, Medical • Publish • 300,000 articles/yr Information Focus is on: company • 2,000 journals • 7,000 Employees • PhD scientists, •Productivity, ROIinformation • 20,000 books • Leading titles (e.g. Cell, The scientists, publishers •Externalization & Collaboration Lancet) • Extensive scientific network • Global STM coverage • 600,000 authors •Diversification • 18,000 titles used in • 300,000 reviewers abstracting, indexing • 70,000 journal editors and •Personalized Medicine • Extensive patent coverage board members (USTPO, EPO, WPO) Our information spans Pharma’s value chain Target Finding Target Validation Lead ID Lead Validation Toxicity Safety Phase I Phase II PoC Phase III Phase IV Post Launch Trusted External R&D Evolving with Pharma R&D I. Identify relevant knowledge that drives R&D II. Disseminate content to scientists, R&D decision makers III. Make content interactive and actionable Creating Insight Identify relevant content that drives R&D ...... the present the past Disseminate Content to Scientists, R&D decision makers ... ... the thepresent past Make Content Interactive and Actionable ... The present ... The past Why is Elsevier here? Because our customers have come here.... Novartis announces USD 1 billion investment to build largest pharmaceutical R&D institute in China Press Release November 2009 ... And our new customers are here What is Reaxys? A workflow solution for researchers in chemistry, drug discovery and related scientific areas Using Reaxys researchers can • • • • Easily access validated reaction and substance data, ranking and filtering for relevant results Source available chemicals Plan and optimize synthetic route Export and share results for immediate action in the lab An extensive repository of reaction and substance property data, Reaxys includes: • • • Organic, inorganic, organometallic chemistry from 400 journals Coverage from 1771 - present World Patent Office, European Patent Office and US English language patents from the major chemistry patent classes Reaxys extracts valuable chemical properties and reaction details from journals and patents. 1H NMR 300 MHZ Five good reasons to use Reaxys 1. The wealth of experimentally validated data which can be searched, filtered and ranked to find the most relevant answer to a specific question quickly. 2. Functionality beyond data searching: synthesis planner, results management, smart analysis tools for fast evaluation. 3. No user or usage limits: flat-rate for institution-wide access at any time. 4. The intuitive interface and online educational material help reduce your training efforts. 5. Interoperable: linking to SciVerse Scopus, fulltexts at publishers and patent offices. Access to your own library settings via OpenURL resolver is possible. Professor Peter Johnson, University of Leeds What our customers say: Peter Johnson, University of Leeds Reaxys is used by 24 of the Top-25* ranked academic chemistry research programs Src: 2011 www.arwu.org Reaxys Case Study: Finding coumarin glycosides What we will do • Search by structure • Filter By substructure, spectra, and bioactivity • Export to a spreadsheet • Create a Synthesis Plan • Use the Form-based and Advanced Search Tabs • Search by Keyword 17 Find coumarin glycosides Examples: Isolate the substances that have NMR data and antibacterial activity O O O O HO O coumarin glucopyranose 5 *bac* bacterio antibac palladium *’ catalyst hydrogenation Reaction type Coumarin NEXT glycosid* glycoside C*marin* NEXT What you have seen • Search by structure • Filter By substructure, spectra, and bioactivity • Export to a spreadsheet • Create a Synthesis Plan • Use the Form-based and Advanced Search Tabs • Search by Keyword 47 Thank You • Reaxys training materials can be found at www.reaxys.com/info • Contact Reaxys Customer Support at: [email protected] if you would like to schedule a Reaxys Advanced Training webinar Thank you • Questions?