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Investigator Portal 1/ Thomson Scientific/ 21 July 2015 Investigator Portal - Key points • Why did Prous Science create Investigator Portal? • Content • • • How much? • Where from? • Functionality - Alerts, saved queries, datasets Development update • New therapeutic areas • Product & Business development Selling Investigator Portal • Features, Benefits & Unique Selling Points • Authentication models • Search examples 2/ Thomson Scientific/ 21 July 2015 Investigator Portal - Key points • Why did Prous Science create Investigator Portal? • Content • • • How much? • Where from? • Functionality - Alerts, saved queries, datasets Development update • New therapeutic areas • Product & Business development Selling Investigator Portal • Features, Benefits & Unique Selling Points • Authentication models • Search examples 3/ Thomson Scientific/ 21 July 2015 5/ Thomson Scientific/ 21 July 2015 Investigator Portal - Target Users Translational Research Team • Clinical researchers • Chemists • Epidemiologists • Pharmacists • Geneticists • Biostatisticians • Biologists • Bioengineers • Pharmacologists • Data managers 6/ Thomson Scientific/ 21 July 2015 Investigator Portal - Key points • Why did Prous Science create Investigator Portal? • Content • • • How much? • Where from? • Functionality - Alerts, saved queries, datasets Development update • New therapeutic areas • Product & Business development Selling Investigator Portal • Features, Benefits & Unique Selling Points • Authentication models • Search examples 7/ Thomson Scientific/ 21 July 2015 Investigator Portal Content – Quantity Knowledge Area Drugs & Biologics Therapeutic Targets Targetscapes Animations Genomics Biomarkers Experimental Pharmacology Pharmacokinetics Clinical Studies Disease monographs Literature Patents Number of records 275.000 6000 30 440 7.500 92 685.000 350.000 83.000 96 810.000 105.000 8/ Thomson Scientific/ 21 July 2015 Investigator Portal Content – Sources Sources of Information • Patent Offices 11 Patent Offices around the world provide constant updates on product patent status • Journals Over 1,500 journals screened regularly, covering disease and treatment information Scientific Congresses Over 350 scientific venues per year covered by medical reporters and writers including official sessions, symposia, poster and oral sessions, coverage • Company Information Press Releases Annual/Quarterly Reports Investor Conferences • Regulatory Agencies FDA / EMEA/PMDA (Japan) • • Contributor Network Over 500 direct collaborators around the world, dedicated to excellence in the delivery of scientific knowledge. • • • • Academia Research centers Scientific societies Clinical practice • Thought leaders • Regulatory agencies • Healthcare industry experts 9/ Thomson Scientific/ 21 July 2015 Investigator Portal - Key points • Why did Prous Science create Investigator Portal? • Content • • • How much? • Where from? • Funcionality - Alerts, saved queries, datasets Development update • New therapeutic areas • Product & Business development Selling Investigator Portal • Features, Benefits & Unique Selling Points • Authentication models • Search examples 10/ Thomson Scientific/ 21 July 2015 Investigator Portal – Development update • New therapeutic areas • Neurological disorders • Psychiatry • Urological disorders • Infectious diseases • AIDS • Digestive diseases • Diabetes • Oncology • Respiratory diseases • Cardiology 11/ Thomson Scientific/ 21 July 2015 Investigator Portal – Development update Product development Business development • Therapeutic areas • • Self registration • Bugs Later today: • Branding • Marketing • Pricing Positioning 12/ Thomson Scientific/ 21 July 2015 Investigator Portal - Key points • Why did Prous Science create Investigator Portal? • Content • • • How much? • Where from? • Funcionality - Alerts, saved queries, datasets Development update • New therapeutic areas • Product & Business development Selling Investigator Portal • Features, Benefits & Unique Selling Points • Authentication models • Search examples 13/ Thomson Scientific/ 21 July 2015 Investigator Portal – The Translational Research Knowledge Base • • Benefits to the Customer/User • Faster access to structured and relevant information – Saves time • Standardised presentation of information – Saves effort • Reduces need for multiple databases – Saves money Unique Selling Points • ‘First in class’ unique information resource for translational researchers • Integrates multiple knowledge areas • Organized by medical specialties • Analyzed, structured and indexed data, (not bibliographic database) 14/ Thomson Scientific/ 21 July 2015 Investigator Portal – Authentication models • Site-wide access • IP range authenticated • Username and Password • Trials 15/ Thomson Scientific/ 21 July 2015 16/ Thomson Scientific/ 21 July 2015 17/ Thomson Scientific/ 21 July 2015 Click here to see the list of therapeutic targets that have been implicated in this pathology 18/ Thomson Scientific/ 21 July 2015 19/ Thomson Scientific/ 21 July 2015 See full record for EGFR 20/ Thomson Scientific/ 21 July 2015 Full record for EGFR 21/ Thomson Scientific/ 21 July 2015 Full record for EGFR Links to external databased with records on EGFR 22/ Thomson Scientific/ 21 July 2015 Links available from the full record include direct link to the Swiss-Prot entry for this target 23/ Thomson Scientific/ 21 July 2015 Links available from the full record include direct link to the Protein Data Bank entry for this target 24/ Thomson Scientific/ 21 July 2015 Prous Science medical writers provide a short overview of each target’s importance in pathological process 25/ Thomson Scientific/ 21 July 2015 See the molecular landscapes showing the involvement of key targets in different disease processes 26/ Thomson Scientific/ 21 July 2015 Scroll down for further data on this therapeutic target 27/ Thomson Scientific/ 21 July 2015 Multimedia animations illustrate in greater detailpathological processes and therapeutic pathways 28/ Thomson Scientific/ 21 July 2015 See which other research groups are developing molecules using the same target 29/ Thomson Scientific/ 21 July 2015 Start networking or keeping an eye on the competition! 30/ Thomson Scientific/ 21 July 2015 Search results are indexed and structured around 12 interlinked Knowledge Areas 31/ Thomson Scientific/ 21 July 2015 Click here for a list of molecules acting on EGFR as a target 32/ Thomson Scientific/ 21 July 2015 We have now jumped to the Drugs & Biologics Knowledge Area for the results related to EGFR as a target 33/ Thomson Scientific/ 21 July 2015 Refine search by regulatory agency 34/ Thomson Scientific/ 21 July 2015 Select only those molecules approved by the Food & Drug Administration (FDA)... 35/ Thomson Scientific/ 21 July 2015 ...and view the subset of results 36/ Thomson Scientific/ 21 July 2015 37/ Thomson Scientific/ 21 July 2015 View the full record for this drug 38/ Thomson Scientific/ 21 July 2015 Full record for lapatinib 39/ Thomson Scientific/ 21 July 2015 Search results are indexed and structured around 12 interlinked Knowledge Area 40/ Thomson Scientific/ 21 July 2015 Click here to see the list of clinical studies related to this molecule 41/ Thomson Scientific/ 21 July 2015 The list of clinical studies related to this molecule 42/ Thomson Scientific/ 21 July 2015 Click here to look at the adverse event profile of this drug 43/ Thomson Scientific/ 21 July 2015 Details of adverse events reported for this drug in clinical studies 44/ Thomson Scientific/ 21 July 2015 Click here to see the biomarkers associated with this molecule 45/ Thomson Scientific/ 21 July 2015 We are now in the recently launched Biomarkers Knowledge Area 46/ Thomson Scientific/ 21 July 2015 Click to access the full record for a given biomarker 47/ Thomson Scientific/ 21 July 2015 Full record for HER2 as a biomarker 48/ Thomson Scientific/ 21 July 2015 49/ Thomson Scientific/ 21 July 2015 Investigator Portal The Translational Research Knowledge base Philip Purnell, M.Sc. Senior Product Manager, Prous Science 50/ Thomson Scientific/ 21 July 2015