Transcript Chemotherapy of Cancer

Chemotherapy of Cancer
Folder Title: Chemothe
Updated: April 6, 2003
(Powerpoint)
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Pitot, Table 20.1
Acquisition of New Anti-Cancer
Drug, 1940 – 1990.
Pitot, Figure 20.1
Needs in Cancer Chemotherapy
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Mechanisms of action beyond DNA synthesis and
microtubule effects on mitosis
Exploitation of tumor-specific cell biology
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Exploitation of physiology beyond cellular level
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Oncogene products and signal transduction
Induction of apoptosis
Reversal of immortalization
Angiogenesis
Invasion and metastasis
New sources of anti-neoplastic agents
Needs
Cell cycle specific anti-cancer agents
Pitot, Figure 20-13
Molecular Mechanisms of Resistance to Chemotherapy
Pitot, Figure 20-10