Transcript PAIN & ANALGESIA

PRINCIPLES OF PAIN
MANAGEMENT & ANALGESIA
“THERE IS NO COMING TO
CONSCIOUSNESS WITHOUT PAIN.”
-CARL JUNG
PRINCIPLES OF PAIN & ANALGESIA
 WHAT IS PAIN?

An unpleasant sensory or emotional experience associated with
actual or potential tissue damage
 Pain results when nerve cells in the skin or deep tissues, called
_______________, detect a noxious stimulus

2 types of sensory neurons that detect and transmit pain
 _________________(large,
myelinated)
 Transmit sharp, discrete pain signals that allow the patient
to localize the source of pain.
 transmits somatic pain
 _________________(small, nonmyelinated)
 Transmit dull, aching, throbbing pain that cannot be easily
localized
 transmits somatic & visceral pain (visceral pain is only
transmitted by C fibers)
PRINCIPLES OF PAIN & ANALGESIA

THE PAIN PATHWAY
 _________________: transformation of noxious
thermal, chemical, or mechanical stimuli into electrical
signals called action potentials by A-delta & C fibers
 _________________: these sensory impulses are
then conducted to the spinal cord
 _________________: in the spinal cord where the
A-delta & C fibers terminate, the impulses can be
altered by other neurons, which either amplify or
suppress them.
 _________________: the impulses are transmitted
to the brain, where they are processed and recognized.
THE PHYSIOLOGY OF PAIN
PRINCIPLES OF PAIN & ANALGESIA
 WHAT IS PAIN?
 __________ arises from the skin, soft tissues,
muscles, bones, or joints
 Easily localized through stabbing, throbbing, or
aching
 ___________arises from internal organs
 not easily localized and is characterized by cramping
or burning
 ____________term used to describe the pain that is
felt in a body part other than where the actual pain
stimulus is coming from
PRINCIPLES OF PAIN & ANALGESIA
 WHAT IS PAIN?
 ______________
is increased sensitivity to a stimulus
 _______________arises from direct damage to
peripheral nerves or the spinal cord.
 May be shooting, sharp, or tingling
 _____________or stump pain is sensation or pain
arising from the missing body part

Pain can also be classified according to onset and duration
 ________ pain has an abrupt onset and a relatively short
duration of action. *Effectively treated with analgesic drugs
 ________ pain has a slow onset, and duration of several
months to years. *May be unresponsive to drug therapy
PRINCIPLES OF PAIN & ANALGESIA
 MYTHS ABOUT PAIN IN ANIMALS
 Consider how some people without medical backgrounds may
view the animal’s response to pain
PRINCIPLES OF PAIN & ANALGESIA
 THE 5 FREEDOMS OF ACCEPTABLE ANIMAL
WELFARE
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Freedom from hunger
Freedom from physical and thermal discomfort
Freedom from pain, injury, & disease
Freedom to express normal behavior
Freedom from fear and distress
PRINCIPLES OF PAIN & ANALGESIA
 WHAT ABOUT OUR ANIMAL PATIENTS AND/OR
OUR JOBS COULD MAKE MONITORING FOR
PAIN and ADMINISTERING ANALGESICS
DIFFICULT?
PRINCIPLES OF PAIN & ANALGESIA
 MONITORING SIGNS OF PAIN
 Consider how we as humans display pain vs. how our animal
patients display pain. Write some ways you can monitor for
pain in animals.
 3 TYPES OF BEHAVIORS ASSOICIATED W/PAIN
IN ANIMALS
PRINCIPLES OF PAIN & ANALGESIA
 PAIN ASSESSMENT
 The measurement of pain is important to:
 Pain scales
 Based on observer’s assessment of patient’s spontaneous
behaviors, and behaviors on handling, interaction, and
manipulation, & maybe physiologic parameters.
 Pain scores should be reassessed regularly and preferably by
the same person to minimize observer variation.
PRINCIPLES OF PAIN & ANALGESIA
 PAIN ASSESSMENT TOOLS: Simple descriptive
scale
PRINCIPLES OF PAIN & ANALGESIA
 PAIN ASSESSMENT TOOLS: Numeric rating scales
PRINCIPLES OF PAIN & ANALGESIA
 PAIN ASSESSMENT TOOLS: Visual analogue scale
 PAIN ASSESSMENT TOOLS: Comprehensive scales
PRINCIPLES OF PAIN & ANALGESIA
 CONSEQUENCES OF UNTREATED PAIN
 Consider the long term effects of untreated pain
PRINCIPLES OF PAIN & ANALGESIA
 PHYSIOLOGICAL SIGNS OF PAIN
PRINCIPLES OF PAIN & ANALGESIA
 WHAT IS ANALGESIA?

___________ is the absence of the awareness of pain, achieved
through the use of drugs or other modes of therapy. It applies to the
relief of pain without the loss of consciousness.
 WHAT ARE THE GOALS FOR PAIN CONTROL?


Control pain at every stage of treatment
to administer analgesics before the patient has an awareness of pain.
This is known as ____________________.
Decreases the analgesic requirements
 Decreases CNS sensitization


To prevent __________ an event caused by a buildup of chemical
mediators that intensify the pain response
PRINCIPLES OF PAIN & ANALGESIA
 METHODS OF PAIN CONTROL WITHOUT MEDS
 _______________ are endogenous compounds produced by
the pituitary gland and the hypothalamus that bind to opioid
receptors during situations of trauma or stress. They resemble
opiates in their ability to provide pain relief and a feeling of wellbeing. “natural pain reliever”

Nursing care:

Other therapies to control pain:
PRINCIPLES OF PAIN & ANALGESIA
 METHODS OF PAIN CONTROL USING MEDS
 OPIOIDS
 NSAIDS
 OTHERS: alpha-2 agonists, ketamine, steroids
 LOCAL ANESTHETICS
METHODS OF PAIN
CONTROL USING MEDS
OPIOIDS
OPIOIDS
 MODE OF ACTION:
 Acts on 4 different receptors in the brain and spinal cord






_______
_______
_______
Sigma(only cause hallucination, euphoria/dysphoria)
An opioid agent may act as an _______ (stimulating agent) or __________
(blocking agent) at each receptor
 Some opioid agents are considered _________________________in
that they block one type of receptor and stimulate another or
_______________in that they only partially stimulate some opioid
receptors
Binding to these receptors can result in a number of effects:
 ANALGESIA
 Respiratory depression
 Sedation
 Dysphoria
 And others,…
OPIOIDS
 REVERSIBILITY
 One major advantage of opioids is their reversibility with pure
antagonists such as ______________, which is the most
effective
 Naloxone competitively binds to opioid receptors

It is also possible to use a mixed agonist/antagonist such as
BUTORPHANOL or a partial agonist such as BUPRENORPHINE
to reverse the effects of the pure agonists
 CONTROLLED
OPIOIDS
 MORPHINE: a FULL AGONIST (stimulates all 4
receptors)

Great for moderate to severe pain
Produces significant sedation
cardiovascular & respiratory depression

SIDE EFFECT/CAUTIONS:





Can cause excitement in cats (use lower doses)
Often results in ______________ due to its effects on the CRTZ
Give slowly IV otherwise severe __________________release can lead to
hypotension and pruritis
 Other FULL AGONISTS include oxymorphone,
hydromorphone, and fentanyl
OPIOIDS
 FENTANYL: a FULL AGONIST
(stimulates all 4 receptors)


the injectable has a rapid onset of action
and short duration of action. Onset of
action: 2 min; duration of effect: 20-30 min
commonly used as a _____________
skin patch
Fentanyl is slowly absorbed through the
skin and may take 4-12 hrs in cats, and 1224 hrs in dogs to reach therapeutic levels
 See pg 230 in your book, Procedure 7-1 for
instructions on placing a fentanyl patch.

OPIOIDS
 METHADONE – a synthetic opioid that has
agonist effects at the mu receptor similar
characteristics to oxymorphone and hydromorphone


Lowest likelihood of causing vomiting
Antagonist of the NMDA receptor



Favorable for treating pain when central sensitization is present
Can be given IV,IM,SC
May last up to 4 hours
OPIOIDS
 MEPERIDINE (or PETHIDINE) – a synthetic
opioid FULL AGONIST, primarily mu and delta
receptor



Weak analgesic properties lasting 1-2 hrs
Short acting overall, up to 6 hrs
Most useful as a part of the pre-anesthetic protocol
OPIOIDS
 BUPRENORPHINE: partial
agonist of the mu receptor(aka
bupi, buprenex)





Delayed onset of action, (40 min IM) but longer
duration of action than other opioids –
___________
Best used for mild to moderate pain
The injectable product is effectively given to
cats _____________________ (applied to
the gingiva, under the tongue, in cheek pouch)
Can be used to reverse the effects of pure
agonists, while maintaining some analgesic
effect. Not as effective as naloxone
THIS DRUG IS PART OF THE VTI PROTOCOL
FOR DOGS & CATS*
OPIOIDS
 BUTORPHANOL: mixed
agonist(kappa,sigma)/antagonist
(mu)(aka torb, torbugesic)




Best used for mild to moderate pain; and is
commonly used as a ________________
Can be used to reverse the effects of pure
agonists. Not as effective as naloxone
Commonly combined with a sedative such as
dexmedetomidine or acepromazine
MIXING AN OPIOID & SEDATIVE IS
KNOWN AS _____________________
OPIOIDS
 TRAMADOL: a non-opiate drug that has agonist
activity at the mu receptor



Oral tablets
Useful post-operative pain med in dogs and cats
Not currently controlled
METHODS OF PAIN
CONTROL USING MEDS
NSAIDS
NSAIDS
 MECHANISM OF
ACTION:

Inhibits the synthesis of
prostaglandins by blocking
the enzyme cyclooxygenase
( aka COX-1 & COX-2)
______ leads to the
production of beneficial
prostaglandins
 ________ leads to the
production of harmful
prostaglandins that are
present during tissue damage
and inflammation.

NSAIDS
 BENEFITS OF NSAIDS:





No strict record keeping
Little abuse potential
Effective when given orally
No sedative, cardiovascular, or respiratory effects
Antipyretic effects
 SIDE EFFECTS/CAUTIONS:

GI upset/GI ulcers due to inhibition of __________




DO NOT USE CONCURRENTLY w/ ___________
______ toxicity due to inhibition of PGE2
hepatic toxicity
Inhibits platelet aggregation due to blockage of ______________
NSAIDS
 RIMADYL (carprofen)
 Approved for use in DOGS ONLY!
 Oral(chewable tablets) and injectable forms available
 Less likely to cause side effects mentioned previously due to its
COX-2 selectivity
 Common uses:
Post-operative pain relief
 Pain relief from osteoarthritis and other musculoskeletal injuries


PART OF THE CANINE POST-OP PAIN CONTROL
PROTOCOL AT VTI
NSAIDS
 METACAM (meloxicam)
 Approved for use in dogs and cats
 COX-2 selective
 Oral and injectable formulations available

PART OF FELINE POST-OP PAIN CONTROL PROTOCOL AT
VTI
NSAIDS
 ONSIOR (Robenacoxib)
 Cox-2 selective
 Oral tablets approved for use in cats only
Approved for use in dogs in other countries
 Given SID

METHODS OF PAIN
CONTROL USING MEDS
OTHERS:
ALPHA-2 AGONISTS
KETAMINE
ALPHA-2 AGONISTS & KETAMINE
 ALPHA-2 AGONISTS (ex: dexdomitor, xylazine)


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Short duration of action (~90 minutes)
Also causes profound sedation, bradycardia
Commonly combined with butorphanol
Reversible (analgesic effects are reversed as well)
 KETAMINE

Works by antagonizing ____________receptors in the spinal cord
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Blocking NMDA receptors prevents central sensitization & windup
Effective for _________analgesia, but limited visceral analgesia
Duration of action is short 30min
METHODS OF PAIN
CONTROL USING MEDS
LOCAL
ANESTHETICS
LOCAL ANESTHETICS
 WHAT IS LOCAL
ANESTHESIA/ANALGESIA?

The use of a chemical agent on sensory neurons to produce a
disruption of nerve impulse transmission, leading to
temporary loss of sensation
LOCAL ANESTHETICS
 CHARACTERISTICS OF LOCAL
ANESTHETICS
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Exert their effects on neurons in the peripheral nervous system
and spinal cord that control pain, heat, cold, & pressure
Relatively few effects of the cardiovascular and respiratory
systems
Exert their effects in the area closest to the site of injection
Not normally transferred across the placenta

Safe for c-sections
LOCAL ANESTHETICS
 ROUTES OF ADMINISTRATION
 TOPICAL: must penetrate the epidermis to reach the dermis
where the peripheral nerves are located
Sprayed on intact skin for superficial procedures such as skin
biopsies (ex: ethyl chloride)
 Creams can also be applied to desensitize skin for superficial
minor procedures (ex: lidocaine/prilocaine)
 Splash blocks refer to the use of sprays or anesthetic soaked gauze
sponges on open wounds or surgical sites
 Applied through a chest tube in patients having thoracic surgery
 Should be done when patient is awake
 Absorbed through the mucous membranes (larynx, eye, urethra)
 Short duration of action and less pain relief when compared to
other routes of administration of local anesthetics

LOCAL ANESTHETICS
 ROUTES OF ADMINISTRATION:
 INFILTRATION(injection):
Local anesthetic can be injected subcutaneously, intradermally, or
between muscle planes
 Ideally the site of injection is clipped and cleaned
 Small needle (23-25 gauge) used to prevent tissue damage
 Test efficacy by pricking the site with a needle
 Do not inject into infected or inflamed tissues


Some local anesthetic drugs are combined with epinephrine
Epinephrine causes vasoconstriction which decreases rate of
absorption and prolonging effect
 It also decreases the amount of drug entering the circulation,
decreasing chances of toxicity.
 CAUTION AROUND AN INCISION OR ON EXTREMITIES AND
WITH PATIENTS WITH CV ABNORMALITIES

LOCAL ANESTHETICS
 ROUTES OF ADMINISTRATION

_________ BLOCKS: Injection of a local anesthetic in the
proximity of a specific nerve to desensitize a specific anatomic
location. Location of target nerve must be known and palpated if
possible.
Lameness exams in horses
 Cornual blocks for dehorning cattle
 Dental blocks in dogs and cats
 Infiltration of nerves during amputation of a limb
 Declawing cats


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May take 15-20 minutes for absorption
Nerve blocks include ________ blocks and ______ blocks
Cornual blocks for dehorning cattle
THIS NERVE BLOCK
IS ALSO A RING BLOCK
Dental blocks for tooth extractions
Maxillary Nerve block via
The infraorbital foramen
NERVE BLOCKS
Nerve blocks help pinpoint areas of pain
Paravertebral block
THESE ARE EXAMPLES OF LINE
BLOCKS
NERVE BLOCKS
THIS NERVE
BLOCK IS ALSO
A RING BLOCK
LOCAL ANESTHETICS
 ROUTES OF ADMINISTRATION
 NERVE BLOCKS


LINE BLOCKS: continuous line of local anesthetics placed SQ in
an area served by numerous small nerves
 The needle is inserted along the line of infiltration and the
anesthetic is injected as the needle is withdrawn
 If placed encircling an anatomic part, it is called a RING
BLOCK
_________________: injecting local anesthetics directly
into a joint usually after surgery of the joint, immediately after
closure of the joint capsule
LOCAL ANESTHETICS
 ROUTES OF ADMINISTRATION
 ____________: blockage of sensory and motor nerves in
the rear, abdomen, pelvis, tail, hind limbs, and perineum

Anesthetist must be familiar with the anatomy of the terminal
spinal cord and lumbosacral vertebrae
Epidural space
Dura mater
arachnoid
Subarachnoid space w/CSF
Pia mater
Spinal cord
LOCAL ANESTHETICS
 EPIDURALS
http://www.youtube.com/watch?v=zmwv
MHZG_5g
SIDE EFFECTS OF LOCAL ANESTHETICS
 Allergy
 Rash or hives in the area
 Systemic toxicity
 Sedation, nausea, restlessness, hyperexcitability, seizures,
respiratory suppression, coma
 Infection (esp. w/epidurals)
 Cranial infiltration of an epidural may cause serious
toxicity, respiratory suppression
 death
METHODS OF PAIN CONTROL
Combining drugs from different categories (multimodal therapy, balanced analgesia) is more
beneficial than using high doses of one medication.
Pain is alleviated via different pathways
SPECIAL TECHNIQUES
NEUROMUSCULAR BLOCKING AGENTS
MECHANICAL VENTILATION
NEUROMUSCULAR BLOCKING AGENTS
 Aka muscle-paralyzing
agents
 These agents act by
interrupting normal
transmission of impulses
from motor neurons to the
muscle synapse

Site of action: ________
_______________, where
acetylcholine is released by the
neurons to attach to muscle end
plates.
NEUROMUSCULAR BLOCKING AGENTS
 Two ways for these agents to disrupt the nervous
transmission


_________________ agents – cause a single surge of activity at the
neuromuscular junction, followed by a refractory period. (Ex:
succinylcholine)
 Animals may show spontaneous muscle twitching followed by paralysis
 Reversal agents are not effective
_________________ agents- block the receptors and the end plate. (ex:
pancuronium, atracurium)
 No initial surge of activity at the neuromuscular junction, no
spontaneous muscle movements.
 These agents can be reversed with neostigmine or
edrophonium
 Not commonly used in vet med, but can be useful in the
following situations.
NEUROMUSCULAR BLOCKING AGENTS
 Neuromuscular blocking agents allow relaxation of voluntary
muscles only. Skeletal muscles are affected in a predictable order



1st- __________________
2nd- __________________
Last- __________________
 ADMINISTRATION
 Normally given slowly IV
 Onset of action: 2 minutes
 Duration: 10-30 minutes
 Animals on these drugs will require manual or mechanical
ventilation
 ADVERSE EFFECTS
 Hypothermia
 Respiratory failure
 Cardiac arrhythmias
MECHANICAL VENTILATION
 Patient’s breathing is controlled by a ________ rather
than _____________________


The ventilator automatically compresses a bellows, which forces
oxygen and anesthetic gas into the patient’s airways
The bellows is compressed at a specified rate and a specified volume
 USES: not normally used in healthy anesthetized
patients, but can be helpful in:
MECHANICAL VENTILATION
MECHANICAL VENTILATION
 Depending on the type of ventilator, the anesthetist
can deliver gases according to a pressure cycle, a
volume cycle, or a time cycle.


________ cycle – supplies air until the pressure reaches a
preset level. This is generally 12 cm to 20 cm.
________ cycle – supplies air according to a set inspiratory
time. This is generally 1 to 1.5 seconds.


I:E ratio is 1:2 to 1:3
__________cycle – delivers a preset tidal volume regardless
of the pressure required. This is generally 10-15 mL/kg
MECHANICAL VENTILATION
 RISKS OF CONTROLLED VENTILATION
 Excessive airway pressure may rupture alveoli
 Cardiac output may be decreased if positive pressure is
maintained throughout inspiration and expiration
 If ventilation rate is too high, excessive carbon dioxide may be
exhaled leading to respiratory alkalosis
 Controlled ventilation is generally more efficient at delivering
anesthetic gas which may lead to exacerbation of side effects
such as hypotension and CNS depression.
 Anesthetist may be tempted to relax on the monitoring