Transcript Part Two: Etiology & Pathophysiology of Chronic Kidney Disease

Part Two: Etiology &
Pathophysiology of Chronic
Kidney Disease
By T. Parent Nurse Educator, PHC
Community Hemodialysis Units 2015
Glomerular disorders
Nephrotic & Nephritic syndromes
Nephrotic syndrome the loss of a lot of
protein
Nephritic syndrome the loss
of a lot of blood
Associated Diseases
Minimal
change
glomerulonep
hritis
Membranoprolif
erative
Glomerulonephri
tis
Membranous
Glomerulonep
hritis
Post
streptococcal
glomerulonep
hritis
Focal
Segmental
glomeruloscl
erosis
Diabetic
Nephropathy
Goodpast
ures
Rapidly
progressive
glomerulone
phritis
HenochSchonlein
purpura
Vasculitis
disorder
Wegners
granulomat
osis
IgA
Nephropath
y
Microscop
ic
polyangiti
s
Churg
Strauss
disease
Vascular Diseases
Microscopic
Polyangiitis
Wegener’s
BLOOD VESSEL SIZE
Small to Medium
Small to
Medium
BLOOD VESSEL TYPE
Arterioles to
venules, And
sometimes
Arteries and veins
Arterioles to
venules, And
sometimes
Arteries and
veins
GRANULOMATOUS
INFLAMMATION
NO
YES
LUNG SYMPTOMS
YES1
YES1
GLOMERULONEPHRITIS
YES
YES
RENAL HYPERTENSION
NO
NO
MONONEURITIS
MULTIPLEX
COMMON
OCCASIONA
L
SKIN LESIONS
YES2
YES2
GI SYMPTOMS
NO
NO
EYE SYMPTOMS
YES4
YES4
ANCA-POSITIVITY
75%
65-90%
CONSTITUTIONALSYMPT
OMS
YES5
YES5
NECROTIZING TISSUE
YES
YES
MICROANEURYSMS
RARELY
RARELY
Medullary sponge kidney
Neoplasms
Interstitial diseases
allergic drug reactions
infections
Acute interstitial nephritis (AIN)
immunologically mediated disorders
infections
Chronic tubulointerstitial nephritis (CTIN
reflux or obstructive nephropath
drugs