Transcript Iboga – mit in resničnost

Ibogaine and cellular metabolism
Traditional use of Iboga
 enteogen - ritual drug
 oneirogen - awake
dreams
 psychostimulant and
tonic
 reconvalescence after
infectious diseases
 aphrodisiac
Use of Iboga/ibogaine in the West
 interruption of addiction
to alcohol, opiates,
nicotine in cocaine
 spiritual growth and
self-realization
 holly sacrament
 use at extreme sports –
mountaineering
 interesting for army
Ibogaine in medicine
 1905: 10–30mg per day
against asthenia
 1939-1970: neuromuscular
stimulant 8mg per pill
against fatigue, depression
and at reconvalescence
after infectious diseases
 1969: 4-5mg/kg as fantasy
enhancer at psychotherapy
Pharmacodynamics of ibogaine
 immediate (acute) effect
 prolonged effect
Pharmacodynamics of ibogaine
 effects last longer than the presence of ibogaine in
the body
 fat deposits of lipophillic metabolite cannot
directly cause the effect for weeks or months
 functional and structural changes are expected
Composition of cell
•nucleic acids
•proteins
•polysaccharides
•lipids
•water
Proteins
•structural
•functional
Structural proteinscytoskeleton
Functional proteinsreceptor
Functional proteinsenzyme
Protein separation by 2-D electrophoresis
Computer scan of gel
Computer scan of gel
“In silico” analysis of results
Spots of interest
Peptide mapping by mass spectrometry
Identification of proteins by matching
with data bases
Induction of energy metabolism related
enzymes in rat brain
Enzyme
Fold
24 h
Fold
72 h
Mr(Da)/pI
Score
Peptide
matching
1.13
3.21
36090/8.14
62
9
Malate
dehydrogenase
1.42
3.64
36117/8.79
54
9
Aldolase
1.23
2.45
39783/8.05
60
9
Pyruvate kinase
1.38
2.94
58314/7.19
70
10
Glyceraldehyde3-phosphate
dehydrogenase
Induction of energy metabolism related
enzymes
Nonspecific activation of metabolism
Interpretation of results
Enhanced energy
availability supports
higher metabolic
turnover and by that
facilitates detoxification
and renewal of tissues.
Besides, consequent mental
agility provides insight
into one’s own
psychological state
Aura and ibogaine
-40 min
+3 h
+54 h
Aura and ibogaine
Aura and ibogaine –
thantanosis
Aura and ibogaine
Aura and ibogaine
Aura and ibogaine
Maybe illumination
and revelation are
proper words to
describe what is at
this moment
difficult to explain
Pharmacodynamics of Entheogen Drugs
- Influence on Gene Expression
- Faculty of Pharmacy, UL
- Biotechnical Faculty, UL
- Faculty of Medicine, UL
- Faculte de Pharmacie,
Universite Montpellier 1,
Montpellier, France
- Institute for Biological
Research Siniša Stankovic,
Belgrade, Serbia
OMI,
Institute of Anthropological Medicine
www.omi.si