Transcript MS Diagnostic Coding

MS Procedural Coding
Prostaglandin Inhibitors
MHA
May 21, 2009
Irene Mueller, EdD, RHIA
Prostaglandins (type of NSAID)
• Misnomer – natural substances widely
distributed in many tissues and body
fluids, but 1st isolated from prostate
• Act on smooth muscle
• Named alphabetically
– Prostaglandin A, B, C, ( PGA, PGB)
• Some older drugs are now known to be
prostaglandin inhibitors - Aspirin
Actions of Prostaglandins
• Reproductive tract
– Aid in ejaculation
– Induction of contractions for elective abortions
• Not effective for inducing labor at end of pregnancy
• Circulatory system
– Increase cardiac output
– PGE keeps ductus arteriosus open
in congenital heart disease
– Prostin VR Pediatric should not
be used in infants with RDS
Prostaglandins Inhibitors
• Analgesic and anti-inflammatory
• Mechanism of action of many of the antiinflammatory agents is to prevent
prostoglandin synthesis at inflammation site
Aspirin (Prostaglandin Inhibitor)
• Aspirin (Acetylsalicylic Acid) Very old drug
– Relieves mild/moderate pain
– Headaches
– Anti-inflammatory in arthritis
• Juvenile rheumatoid arthritis
– Reduces platelet aggregation
• Prevents blood clots
Other Prostaglandin Inhibitors
•
•
•
•
•
Indocin- arthritis, closing ductus arteriosus
Tolectin - arthritis, bursitis
Motrin - anti-inflammatory, menstral cramps
Feldene - long half-life, one-a-day dosing
Toradol - IM for acute pain, postop
– Orally for headaches, dental, and chronic
recurrent pain
• Naprosyn, Ibuprofen, Indomethacin,
Naproxen, Piroxicam
Side effects of Prostaglandin Inhibitors
• Gastric irritation, best taken 1/2 hour
BEFORE meals
• Bleeding disorders
– Bleeding gums, black stools, petechiae
– Discontinue before surgeries
• Allergies
• Fluid retention, maybe indicated by blood
pressure
• Reye’s syndrome w/aspirin in viral infections
– Often fatal; encephalopathy and liver damage