Transcript Document
NE CENTER FOR NEUROLOGICAL DISORDERS • • • • • • • • • Group Members Tsuneya Ikezu - Dept of Pharmacology - UNMC Yutong Liu -Dept of Radiology - UNMC Li Tan - Engineering Mechanics - UNL Luwen Zhang - Virology Center - UNL David Holtzclaw - Dept of Physiology - UNMC Yazen Alnouti - Dept. of Pharmaceutical Sci - UNMC Ron Cerny - Dept. of Chemistry - UNL David Berkowitz - Dept of Chemistry - UNL Charge: • Your task is to develop core ideas/projects for an $8-10M ($1.25-1.5M per year for 5 years) NIH Center proposal. • Specifically, you should consider the following questions Briefly describe the core projects your group would design for the Center. Please dream big. • Alz-Novel Druggable Target 1:Identification of the first inhibitors for Tao-Tubulin Kinases (TTBK) I and II (I-Alzheimers, II-Spinocerebellar ataxia) -Ikezu • Alz-Novel Druggable Target 2:Identification of the first inhibitors for Serine Racemase (hSR) (Alzheimers, stroke)-Berkowitz • CNS-Lymphoma: Interferon Regulatory Factor-4 (IRF4) as novel transcription factor/emerging lymphoma target-Zhang • Novel Approaches to Neuro-Imaging Use of Mn-, Gd- and Fe-based paramagnetic contrast agents for neuro-MRI (50 uM resolution/stroke model) -Liu, fluorescence with novel self-assembled agents- Tan • Drug Metabolism/Optimization Cyt-P450-based drug candidate metabolism - hot spot/byproduct identification by LC/MS-Alouti, Cerny Identify the key faculty from from both campuses to involve in these projects. Include their strengths. (UNMC on next slide) • UNL Faculty David Berkowitz Li Tan Ron Cerny Luwen Zhang Pat Dussault James Takacs Strengths Enzyme Inhibitor Development Novel Fluorescent Materials NE Proteomics Center Director NE Virology - Lymophoma Medicinal/Natural Prod Chem Medicinal/Natural Prod Chem Identify the key faculty from from both campuses to involve in these projects. Include their strengths. • UNMC Faculty Tsuneya Ikezu Howard Gendelman Yazen Alnouti Yutong Liu David Holtzclaw Hong Sun Strengths Neurodegen Disorders Nanomedicine Drug Metab/Pharmacokinetics Radiology/MRI Fluid Mechanics Rat Stroke Model (Physiol) Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects. Harvard Neurodegenerative Disorder Program (High throughput drug screening) UNMC MRI Center ( Liu) NE Center for Proteomics (Cerny) KU cpd library & HTS facility (Scott Wier) List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested. Neumedix - Australia/Cayman Islands (VC interest in TTBK inhibition with Prof. Ikezu) Merck, Wyeth-Pfizer, Astrazeneca, GSK, BMS (Drug development for Alzheimers, stroke and CNS-lymphoma) Describe how you would link the Center to other campus resources. UNMC MRI platform (Liu) UNMC DMPK Center (Alnouti) NCND UNL MS Center (Cerny) Neurodegen Disease Center (UNMC) (Ikezu)