Transcript PowerPoint - International AIDS Society-USA

Mutations in the Reverse Transcriptase Gene Associated With Resistance
to Reverse Transcriptase Inhibitors
Nucleoside and Nucleotide Analogue Reverse Transcriptase Inhibitors (nRTIs)
Multi-nRTI Resistance: 69 Insertion Complex (affects all nRTIs currently approved by the US FDA)
Multi-nRTI Resistance: 151 Complex (affects all nRTIs currently approved by the US FDA except tenofovir)
Multi-nRTI Resistance: Thymidine Analogue-Associated Mutations (TAMs; affect all nRTIs currently approved by
the US FDA)
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.
Mutations in the Reverse Transcriptase Gene Associated With Resistance to
Reverse Transcriptase Inhibitors (cont’d)
Abacavir
Didanosine
Emtricitabine
Lamivudine
Stavudine
Tenofovir
Zidovudine
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.
Mutations in the Reverse Transcriptase Gene Associated With Resistance to
Reverse Transcriptase Inhibitors (cont’d)
Nonnucleoside Analogue Reverse Transcriptase Inhibitors (NNRTIs)
Efavirenz
Etravirine
Nevirapine
Rilpivirine
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.
Mutations in the Protease Gene Associated With Resistance to Protease Inhibitors
Atazanavir
+/-ritonavir
Darunavir/
ritonavir
Fosamprenavir/
ritonavir
Indinavir/
ritonavir
Lopinavir/
ritonavir
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.
Mutations in the Protease Gene Associated With Resistance to Protease Inhibitors
(cont’d)
Nelfinavir
Saquinavir/
ritonavir
Tipranavir/
ritonavir
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.
Mutations in the Envelope Gene Associated With Resistance to Entry
Inhibitors
Enfuvirtide
Maraviroc
User Notes available at www.iasusa.org
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.
Mutations in the Integrase Gene Associated With Resistance to Integrase
Strand Transfer Inhibitors
Dolutegravir
Elvitegravir
Raltegravir
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.
IAS–USA Drug Resistance Mutations Group
2014 Update of the Drug Resistance
Mutations in HIV-1
Annemarie M. Wensing, MD, PhD, Vincent Calvez, MD, PhD, Huldrych F.
Günthard, MD, Victoria A. Johnson, MD; Roger Paredes, MD, PhD, Deenan
Pillay, MD, PhD, Robert W. Shafer, MD, and Douglas D. Richman, MD
Top Antivir Med. 22(4):642-650. Updates available at
www.iasusa.org.
IAS–USA is a not-for-profit, HIV clinical specialist–education organization.
It is entirely different from and not affiliated with the International AIDS Society.
© 2014. IAS–USA
Wensing et al. Top Antivir Med. 2014;22(3):642-650.
Updates, user notes, and references available at www.iasusa.org.