Transcript tablets
TABLETS a mixture of powders compacted to form a single, rigid body most common dosage form possess a number of advantages B. Amsden CHEE 440 Types • intended for release into GIT compressed tablets multiple compressed tablets • effervescents • chewable • buccal or sublingual • vaginal • coated tablets polymer film, gelatin • extended release • immediate release B. Amsden CHEE 440 Desired Properties • contains stated amount of drug • able to withstand stresses of manufacture, transport and handling • provides desired bioavailability • acceptable to patient B. Amsden CHEE 440 Drug Release B. Amsden CHEE 440 Tabletting Process Basics powders fed into a die powder compressed between punches tablet ejected from die B. Amsden CHEE 440 Machinery rotary tablet press B. Amsden CHEE 440 Tablet Components drug (5-10%) fillers (80%) binders disintegrants antifrictional agents antiadherents, glidants, lubricants miscellaneous B. Amsden CHEE 440 Tabletting Powder Properties free flowing particles cohesion of particles upon compaction compacted particles must not adhere to punches and die 3 tabletting methods wet granulation dry granulation direct compression B. Amsden CHEE 440 Powder flow important to obtain uniform flow affected by particle properties adhesion cohesion size shape density B. Amsden CHEE 440 Powders packing geometry shifting under vibration affected by size and size distribution B. Amsden CHEE 440 Powders flow affected by hopper design How to improve hopper flow? B. Amsden CHEE 440 Wet Granulation B. Amsden CHEE 440 Dry Granulation B. Amsden CHEE 440 Direct Compression B. Amsden CHEE 440