Transcript The European HealthGrid Initiative

HEALTHGRID.ORG
The European
HealthGrid Initiative
e-Health and the Grid: Projects and
Prospects in the European Union
Tony Solomonides on behalf of
The HealthGrid Association
NEC 2005
40 years
HEALTHGRID.ORG
Issues and Projects
What is a ‘healthgrid’?
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combines Grid and e-Science ideas
oriented to biomedical advances
supports evidence-based practice
What projects?
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imaging for diagnosis and treatment
simulation for treatment guidance
bioinformatics for biomedicine
legal, ethical, security and trust issues
[email protected]
NEC 2005
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HEALTHGRID.ORG
History
HealthGrid 2003 – Lyon, Jan 03
HealthGrid Association incorporated
HealthGrid 2004 –
Clermont-Ferrand, Jan 04
HealthGrid ‘White Paper’, June 04
HealthGrid 2005 – Oxford, Apr 05
FP6 Project ‘SHARE’ – December 05
HealthGrid 2006 – Valencia, June 06
[email protected]
NEC 2005
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HEALTHGRID.ORG
Principal Themes
Integration
Levels of life & knowledge:
correspondence & convergence
Issues of ethics and trust
Services on grid infrastructure
[email protected]
NEC 2005
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HEALTHGRID.ORG
Principal Theme 1
Integration
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medical and bioinformatics
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patient information and medical knowledge
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‘gold standard’ evidence and practice-based
evidence
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patient data – images, labs, history
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models of the human body
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legal, ethical, social, trust issues
[email protected]
NEC 2005
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Example 1
HEALTHGRID.ORG
Knowledge Grid
EU project to prototype a pan-European
distributed database of mammographic
images using Grid Technologies.
Aim: To provide a demonstrator for use
in epidemiological studies, quality control
and validation of computer aided detection
algorithms.
[email protected]
NEC 2005
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Grid Architecture
HEALTHGRID.ORG
Workstations
Workstations
MG W/s
(‘‘MAS’’)
CERN
Udine
MammoGrid
Data
MammoGrid
Data
GridBox
High
Security
Level
GRID
VPN
MammoGrid
Data
MammoGrid
Data
GridBox
GridBox
Oxford
Cambridge
MG W/s
(‘‘MAS’’)
[email protected]
NEC 2005
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HEALTHGRID.ORG
Grids and Imaging 1
Diagnosis
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comparison, ‘find-one-like-it’
Epidemiology
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virtual databases
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significant statistics
Therapy planning
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targetting, implantation, surgery
Problems of heterogeneity
Security Issues
[email protected]
NEC 2005
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HEALTHGRID.ORG
Grids and Imaging 2
Service Oriented Architecture
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grid services can deal with heterogeneity
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grid services can be used to plan workflow
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examples include annotation, detection,
analysis, registration, aggregation and
visualization services
Optimistically …
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legal, ethical, social and trust negotiations
may be implemented through services
[email protected]
NEC 2005
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Example 2
HEALTHGRID.ORG
Grid
Software
Computational Grid
Simulation &
Imaging
Bio-numeric
modelling
Medical
Expertise
Legal
Aspects
Secure & lawful Grid provision of medical services
Build 6 Grid-enabled medical prototype applications
Build suitable middleware on top of common standards
Install and evaluate a GEMSS test-bed
Anticipate privacy, security & other legal concerns
Taken from Gerhard Engelbrecht
[email protected]
NEC 2005
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Applications
HEALTHGRID.ORG
Name
Domain
Class
Maxillofacial
surgery simulation
Medicine – pre-surgical
planning
On demand / distributed
supercomputing
Neurosurgery
support
Medicine – intra-operative
planning
On demand
Radiotherapy
planning
Medicine – Monte Carlo
treatment simulation
On demand / distributed
supercomputing
Inhaled drug
delivery planning
Medicine – air flow
dynamics
On demand / distributed
supercomputing
Cardio-vascular
system simulation
Medicine – blood flow
dynamics
On demand
Advanced image
reconstruction
Medicine – nuclear / in vivo
diagnostics
On demand
Taken from Gerhard Engelbrecht
[email protected]
NEC 2005
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HEALTHGRID.ORG
Principal Theme 2
Levels of life
Levels of knowledge
Correspondence and
convergence
medicine and genomics
 ‘molecular medicine’
 ‘individualized healthcare’
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[email protected]
NEC 2005
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HEALTHGRID.ORG
I
N
B
I
O
M
E
D
Public Health
Informatics
Medical
Informatics
Medical
Imaging
Bioinformatics
[email protected]
Bio-social being & pathology
P
A
Population
Genomic
T
Epidemiology
Disease
H
O
Pharmacogenetics
Patient
L
O
Molecular and
Tissue, organ
Image-based
diagnosis
G
Molecular, genetic
I
E
Taken from Fernando Martín-Sánchez
S
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HEALTHGRID.ORG
An example:
Integration of clinical and genetic info
from heterogeneous remote databases
A vocabulary server that aims to combine
existing terminology systems in Medicine
and Genetics
Novel framework for clinicians to locate,
search, access, retrieve and use genomic
information in patient care
Taken from Fernando Martín-Sánchez
[email protected]
NEC 2005
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HEALTHGRID.ORG
[email protected]
NEC 2005
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HEALTHGRID.ORG
[email protected]
NEC 2005
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HEALTHGRID.ORG
[email protected]
NEC 2005
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HEALTHGRID.ORG
Principal Theme 3
‘LEST’ Issues
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use of data in care and in research
data provenance
privacy / confidentiality
security
national / EU legal framework
… extending the concept of a ‘virtual
organization’
 & building negotiation into the
infrastructure
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[email protected]
NEC 2005
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GRIDs and Privacy
HEALTHGRID.ORG
Good reasons for talking about privacy here and now!
– The HealthGrid promises access to large amounts of
heterogeneous distributed data
– Health related information is very sensitive and prone to
abuse
– Privacy impacts society as a whole
(e.g. loan applications, insurance, scholarship, ...)
– Privacy violation is irreversible
– Confidential information can never be considered
confidential again, once it was out in the open
– Grid and Privacy Enhancing Technology exist and are used
They could both benefit from early integration
Adapted from Georges de Moor and Brecht Claerhout
[email protected]
NEC 2005
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Sharing of Healthcare Data
HEALTHGRID.ORG
Local Database
Local Databases:
– Nominative records
(e.g. patient
treatment)
– Privacy protected
DBs
Privacy Protecting Interface
(PETs):
– Locally controlled
– Pseudonymisation
– Content filtering and
transformation
– Query evaluation
(restriction)
Privacy
Protecting
Interface
Data Access through the Grid
Adapted from Georges de
Moor and Brecht Claerhout
[email protected]
NEC 2005
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HEALTHGRID.ORG
Principal theme 4
A Grid Infrastructure for Health Applications
Technology attitude
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To build on what already exists
To build only what is necessary
Healthgrid
Components
Healthgrid
Applications
Clinical Data
Grid Infrastructure
[email protected]
NEC 2005
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Layered Grid Technologies
HEALTHGRID.ORG
Data
Abstraction
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Data mining, visualisation,
simulation, problem solving
methods/environments …
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Metadata, middleware,
intelligent retrieval,
information modelling,
warehousing, workflow …
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Distributed databases,
streaming, near-line storage,
large objects, access
mechanisms, data staging …
Knowledge Grid
Information Grid
Data Grid
Data
Control
[email protected]
NEC 2005
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A Grid Infrastructure for
Health Applications
HEALTHGRID.ORG
To address the problems of
integration of multi-level medical data, and
the exploitation of its intrinsic knowledge
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through a health-specific grid Infrastructure and a set of grid
applications for health.
To integrate
grid infrastructures,
health-related grid components, and
pilot applications
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to provide a workbench for medical and clinical support.
To develop components to link
the available expertise,
data, and
resources.
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to demonstrate the benefits through pilots in epidemiology
and personalised healthcare.
[email protected]
NEC 2005
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HEALTHGRID.ORG
Benefits Expected
At the patient level
Personalised healthcare, e.g. through simulation in
therapy.
Improvement in the effectiveness of health policies
through epidemiological studies.
At the medical professional level
Development of federated databases and collaborative
communities.
Development of services to support diagnosis and
therapy in day-to-day work.
At the IT Level
A workbench for the development of tools and services
towards specific features of healthcare IT.
[email protected]
NEC 2005
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20 Years of eHealth R&D Context
HEALTHGRID.ORG
NEXT
PAST 10 years (1991-2002)
’89-’91
’91-’94
Computer
Applications for
Doctors
’94-’98
’98-’02
- informatics for Genomic Medicine
Personal Health
Systems
- Virtual Physiological Human
@
Budget
Budget
Budget
100M €
140M €
200M €
20M €
Projects
Projects
Projects
Projects
63
158
125
Results
Results
batch of
Products
EU Health
Results
Results
AIM
FeasibilityCommunity
Study
Biomedical Informatics
Home-care systems
Budget
30
’02-’06 Research activities
(200 Mil. €)
Regional Health Info
Networks
Telemedicine systems
and services
1st
10 years (2003-2014)
Telematics
-HealthGrid
Personal health systems (Wearable &
Implantable)
based on new biosensors
Decision Support Syst./Patient Safety
Currently preparing activities for ’06-’10
Industry
www.cordis.lu/ist/directorate_c/ehealth/index.html
[email protected]
NEC 2005
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EC - ICT for Health
Current Activities and Plans
HEALTHGRID.ORG
Basic
research
Biomedical informatics
III
HealthGrid
Applied/
Industrial
R&D
II
Decision Support Systems
Personal Health Systems (wearables)
I
Health info networks & services
EHR & interoperability
Support to eHealth “Action Plan”
General issues
EHR, Security,
Interoperability
Deployment
5 years
[email protected]
10 years
NEC 2005
15 years
Time to results
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CISTRANA - IST ERA
HEALTHGRID.ORG
I
eHealth ERA
III
II
SYMBIOMATICS
BMI ERA Pilot
I2HEALTH
Identification
doctors/patient
Messages/requests
SHARE
Healthgrid
STEP
VH CA
Certification EHR
SSA
Semantic Health
Interoperability
TMA Bridge
Interop.
approach
Implementation
[email protected]
RIDE
Interoperability
INFOBIOMED
SEMANTIC MINING
Short time research
NEC 2005
BIOPATTERN
Long time research
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HEALTHGRID.ORG
More information
References
 http://lyon2003.healthgrid.org/program.php
 http://clermont2004.healthgrid.org/program.php
 http://oxford2005.
healthgrid.org/program.php
HG2004, HG2005 Proceedings
‘White paper’
 http://www.healthgrid.org/download.php
(June 2004)
SHARE Project – Road Maps
[email protected]
NEC 2005
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